Medicine - Dunedin
Recent Deposits
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Methylated Circulating Tumour DNA in Myeloma
Myeloma is an incurable malignancy of plasma cells in the bone marrow. Improvements in myeloma treatment have highlighted the need for more sensitive non-invasive measures of residual disease. Circulating tumour DNA in the ... -
Dietary intake in irritable bowel syndrome and its effect on the microbiota
Irritable bowel syndrome (IBS) is a common gastrointestinal condition which affects ~11% of the population worldwide. It is heterogeneous in presentation and underlying pathophysiology which has led to difficulties finding ... -
Quantitative Electroencephalogram Neuroimaging in Obesity
Efforts to understand and treat obesity come from a wide range of disciplines. Neuroimaging in obesity is typically performed with fMRI and PET, which are indirect measures of neural activity. EEG is a direct measure of ... -
Effect of high intensity interval training on the left ventricular performance in the type 2 diabetic heart
Early studies in the 1970s revealed the now well-established link between diabetes and cardiovascular disease, the main cause of death and disability among this cohort. It is believed that biochemical changes to the proteins ... -
Osteoarthritis of the knee joint and hyperextension of the knee joint after stroke
Introduction: Some physiotherapists are reluctant to allow their patients to walk on a hyperextended knee after stroke in the unproven belief that it will precipitate the development of symptomatic osteoarthritis of the ... -
The real-world outcomes from high intensity interval training, intermittent fasting and whole-food diets
Background: Given global epidemics of obesity and diabetes, it is clear that adherence to current nutrition and activity guidelines is insufficient. Novel lifestyle interventions such as high intensity interval training ... -
Improving Exercise Compliance in Patients with Inflammatory Bowel Disease
Background: Regular physical activity offers numerous health benefits to an individual. Worryingly the level of physical activity participation worldwide is at an all-time low and patients with Inflammatory Bowel Disease ... -
Cardiovascular Risk Factors and Retinal Vessel Calibre. What is the Longitudinal Relationship?
Background: Cardiovascular disease is a leading cause of death worldwide. Retinal vessel calibre is a non-invasive in vivo marker of cardiovascular disease and is linked to cardiovascular risk factors. However, the ... -
MUSIC for Medical Students: Validation of the MUSIC Model of Academic Motivation in New Zealand
Introduction/background: An important aspect of student learning is that of academic motivation. Academic motivation can be defined as “a process that is inferred from actions … and verbalizations …, whereby goal- directed ... -
Vision screening in the Southern and Tairawhiti DHBs: An audit of the B4 School Check
Amblyopia, or ‘lazy eye’, describes visual impairment occurring due to abnormal cortico-visual development as a child, and is the most common ophthalmological condition in children. The critical period for visual development ... -
Cardiorenal syndrome in a transgenic hypertensive rat model
Hypertension is a leading cause of cardiovascular disease and myocardial infarction (MI), and these are strongly associated with renal injury. However, the impact of MI additional to the effect of hypertension on renal ... -
Pacific youth views on health and wellbeing: a photovoice study
Preliminary findings from an ongoing study partnership between the Pacific Trust Otago and the University of Otago have reported an association between measures of wellbeing, mental health and markers of metabolic ill-health ... -
SOPARIX Study – PHOX2A (ARIX) and PHOX2B Gene Analysis of a Cohort with Radiologically-Proven Congenital Superior Oblique Palsies
Introduction: Congenital superior oblique palsy (CSOP) remains enigmatic in terms of diagnosis, classification, and pathophysiology. Tendon abnormalities are commonly recognized intra-operatively, whilst recent orbital ... -
The value of hypnotism in the general practice of medicine
[…] For several years I studied very carefully the pretensions of various mesmerists, faith healers, etc, but until I had travelled in the East I was sadly convinced that there were many liars in the world and the greatest ... -
Dynamic pupillometry in a cohort of individuals with type II diabetes mellitus and establishing a relationship between pupillary dysfunction and the severity of diabetic retinopathy.
Background: Six hundred and forty-two million people will be living with diabetes mellitus (DM) by 2040. (1) Diabetic retinopathy (DR) accounts for 4.8% of the thirty seven million cases of blindness worldwide. Autonomic ... -
The Physiological Changes That Occur Post Endovascular Renal Denervation in Dialysis Patients
Sympathetic neural activation is markedly increased in end-stage kidney disease (ESKD). Catheter-based renal denervation (RDN) reduces sympathetic over-activity and blood pressure in resistant hypertension. The effect of ... -
The Teaching of Clinical Reasoning by Senior Clinicians
Background. At our medical school, the teaching of clinical reasoning starts in a well-structured curriculum in the pre-clinical years. In the clinical years, however, teaching is less structured and delivered by multiple ... -
The effect of different monitoring strategies on weight, health, and eating behaviour
A variety of dietary and exercise approaches appear to be effective for weight management in the short-term, however these need to be accompanied by behavioural strategies to make them sustainable long-term. One of the ... -
The Genetics of Familial Biliary Atresia in a New Zealand Iwi
Studying the genetics of disease susceptibility in populations that are small or understudied will further the understanding of the aetiology of rare and/or complex diseases. Biliary atresia is a rare, usually sporadic, ... -
Exhaled nitric oxide and the clinical control of airway inflammation
Measurements of exhaled nitric oxide (eNO) are non-invasive and easily measured. Levels have been postulated as providing an indication of underlying airway inflammation. This series of studies was conducted to investigate ...