Medicine - Dunedin
Recent Deposits
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Effects of vasoactive agents on tumour blood flow and cytotoxic drug uptake.
Response of tumours to chemotherapy is limited by resistance, inherent or developing during treatment, causes of which include impaired drug delivery and changes in cellular drug transport. Although high-dose intravenous ... -
Proceedings of the Health Professional Education Research Symposium 2017
This symposium was the first of its kind at the Dunedin School of Medicine. It was intended to provide a welcoming and supportive environment. To promote research and scholarship into health professional education at the ... -
Does a novel genetic variant, highly expressed in Samoans, explain their increased propensity to develop Chronic Kidney Disease? A pilot study.
Chronic Kidney Disease (CKD) continues to increase globally. In a New Zealand, a community based prevalence study, Pacific peoples had a 2.56 fold higher risk of CKD, controlling for diabetes. Likewise Pacific people ... -
Effects of high intensity interval training vs moderate intensity continuous training on fitness and body composition in active breast cancer survivors
Background: Breast cancer and its treatment are associated with worsened body composition and cardiorespiratory fitness (CRF) in breast cancer survivors. These negative effects can increase overall, cardiovascular and ... -
EEG Biofeedback for Memory
The brain has an ordered structure of functional connections within brain networks, but this order becomes disrupted in Alzheimer’s disease (AD). The default mode network (DMN) and its central hub, the Posterior Cingulate ... -
Running through the fog: A feasibility study on early exercise implementation in sports-related concussion recovery
Safely advising a sports related concussion (SRC) patient though their recovery presents risks to the clinician, coach, and most importantly, to the athlete affected. The current consensus holds that there is insufficient ... -
microRNA expression in the plasma of participants with Parkinson's disease
Parkinson’s disease (PD) is a progressive neurological disorder that affects 1% of the population over the age of 60. The diagnosis of Parkinson’s disease is based on the cardinal feature of bradykinesia along with two of ... -
Identifying Nutritional Concerns and Dietary Support Requirements for Patients with Neuroendocrine Tumours
Background: Neuroendocrine Tumours (NETs) are a diverse group of cancerous tumours arising from cells of the neuroendocrine system. NETs are often reported in the literature as rare tumours, however their prevalence is ... -
Assessment of occupational noise-induced hearing loss for ACC: A practical guide for otolaryngologists
The guideline includes summaries of ACC-commissioned systematic literature reviews on key aspects of ONIHL, and references to resources to assist you to provide robust, evidence- based reports. Background information on ... -
Methylated Circulating Tumour DNA in Myeloma
Myeloma is an incurable malignancy of plasma cells in the bone marrow. Improvements in myeloma treatment have highlighted the need for more sensitive non-invasive measures of residual disease. Circulating tumour DNA in the ... -
Dietary intake in irritable bowel syndrome and its effect on the microbiota
Irritable bowel syndrome (IBS) is a common gastrointestinal condition which affects ~11% of the population worldwide. It is heterogeneous in presentation and underlying pathophysiology which has led to difficulties finding ... -
Quantitative Electroencephalogram Neuroimaging in Obesity
Efforts to understand and treat obesity come from a wide range of disciplines. Neuroimaging in obesity is typically performed with fMRI and PET, which are indirect measures of neural activity. EEG is a direct measure of ... -
Effect of high intensity interval training on the left ventricular performance in the type 2 diabetic heart
Early studies in the 1970s revealed the now well-established link between diabetes and cardiovascular disease, the main cause of death and disability among this cohort. It is believed that biochemical changes to the proteins ... -
Osteoarthritis of the knee joint and hyperextension of the knee joint after stroke
Introduction: Some physiotherapists are reluctant to allow their patients to walk on a hyperextended knee after stroke in the unproven belief that it will precipitate the development of symptomatic osteoarthritis of the ... -
The real-world outcomes from high intensity interval training, intermittent fasting and whole-food diets
Background: Given global epidemics of obesity and diabetes, it is clear that adherence to current nutrition and activity guidelines is insufficient. Novel lifestyle interventions such as high intensity interval training ... -
Improving Exercise Compliance in Patients with Inflammatory Bowel Disease
Background: Regular physical activity offers numerous health benefits to an individual. Worryingly the level of physical activity participation worldwide is at an all-time low and patients with Inflammatory Bowel Disease ... -
Cardiovascular Risk Factors and Retinal Vessel Calibre. What is the Longitudinal Relationship?
Background: Cardiovascular disease is a leading cause of death worldwide. Retinal vessel calibre is a non-invasive in vivo marker of cardiovascular disease and is linked to cardiovascular risk factors. However, the ... -
MUSIC for Medical Students: Validation of the MUSIC Model of Academic Motivation in New Zealand
Introduction/background: An important aspect of student learning is that of academic motivation. Academic motivation can be defined as “a process that is inferred from actions … and verbalizations …, whereby goal- directed ... -
Vision screening in the Southern and Tairawhiti DHBs: An audit of the B4 School Check
Amblyopia, or ‘lazy eye’, describes visual impairment occurring due to abnormal cortico-visual development as a child, and is the most common ophthalmological condition in children. The critical period for visual development ... -
Cardiorenal syndrome in a transgenic hypertensive rat model
Hypertension is a leading cause of cardiovascular disease and myocardial infarction (MI), and these are strongly associated with renal injury. However, the impact of MI additional to the effect of hypertension on renal ...