Medicine - Dunedin
Recent Deposits
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SOPARIX Study – PHOX2A (ARIX) and PHOX2B Gene Analysis of a Cohort with Radiologically-Proven Congenital Superior Oblique Palsies
Introduction: Congenital superior oblique palsy (CSOP) remains enigmatic in terms of diagnosis, classification, and pathophysiology. Tendon abnormalities are commonly recognized intra-operatively, whilst recent orbital ... -
The value of hypnotism in the general practice of medicine
[…] For several years I studied very carefully the pretensions of various mesmerists, faith healers, etc, but until I had travelled in the East I was sadly convinced that there were many liars in the world and the greatest ... -
Dynamic pupillometry in a cohort of individuals with type II diabetes mellitus and establishing a relationship between pupillary dysfunction and the severity of diabetic retinopathy.
Background: Six hundred and forty-two million people will be living with diabetes mellitus (DM) by 2040. (1) Diabetic retinopathy (DR) accounts for 4.8% of the thirty seven million cases of blindness worldwide. Autonomic ... -
The Physiological Changes That Occur Post Endovascular Renal Denervation in Dialysis Patients
Sympathetic neural activation is markedly increased in end-stage kidney disease (ESKD). Catheter-based renal denervation (RDN) reduces sympathetic over-activity and blood pressure in resistant hypertension. The effect of ... -
The Teaching of Clinical Reasoning by Senior Clinicians
Background. At our medical school, the teaching of clinical reasoning starts in a well-structured curriculum in the pre-clinical years. In the clinical years, however, teaching is less structured and delivered by multiple ... -
The effect of different monitoring strategies on weight, health, and eating behaviour
A variety of dietary and exercise approaches appear to be effective for weight management in the short-term, however these need to be accompanied by behavioural strategies to make them sustainable long-term. One of the ... -
The Genetics of Familial Biliary Atresia in a New Zealand Iwi
Studying the genetics of disease susceptibility in populations that are small or understudied will further the understanding of the aetiology of rare and/or complex diseases. Biliary atresia is a rare, usually sporadic, ... -
Exhaled nitric oxide and the clinical control of airway inflammation
Measurements of exhaled nitric oxide (eNO) are non-invasive and easily measured. Levels have been postulated as providing an indication of underlying airway inflammation. This series of studies was conducted to investigate ... -
Intuitive eating in pregnancy
Excess gestational weight gain increases health risks for mother and child in the short and longer term. Meta-analyses of trials designed to optimise gestational weight gain show positive fetal and maternal effects. However, ... -
Circulating anti-Müllerian hormone in the older man
This thesis provides the first description of circulating anti-Müllerian hormone (AMH) in older men. AMH is a gonadal hormone, with overt function in the generation of the male phenotype during development, and a biomarker ... -
Sleep Problems and Sleep Disordered Breathing in Children
Introduction. Sleep disturbances in children can result from extrinsic learned behaviours that become poor sleep habits, or they can arise from intrinsically caused disorders that may require medical treatment. Some sleep ... -
Vestibular Function in Vestibular Schwannoma
Abstract Introduction: Traditionally vestibular function has been assessed using caloric irrigations; new methods have failed to reach the same level of accuracy. Vestibular nerve dysfunction occurs with ‘acoustic neuroma’ ... -
Identifying and Overcoming the Barriers to Smoking Cessation in Rheumatoid Arthritis
The association between smoking and rheumatoid arthritis (RA) is well established. The risk of developing RA is higher among smokers. Smoking may also affect the severity of disease and reduce the efficacy of medications. ... -
Investigations of Heterogeneity, Directionality, and Involvement of Associative Memory in Synaesthesia
Abstract The perceptual phenomenon of synaesthesia involves perception of additional, unrelated sensory experience (concurrent) when a stimulus is perceived (inducer). For grapheme-colour synaesthetes, perceptions ... -
Saccades, eye-hand movement and cognition in Huntington's disease: a 12 month study
Huntington’s disease (HD), a genetically inherited neurodegenerative disease caused by CAG trinucleotide repeat expansion, is characterised by movement disorders, cognitive impairment, and behavioural disorders. Saccadic ... -
Fatigue in Inflammatory Bowel Disease
Introduction: Fatigue is a common yet undertreated symptom in patients with Inflammatory Bowel Disease (IBD). Treating underlying inflammation lead to improved health outcomes and fatigue. However, fatigue can persist in ... -
Risk and challenge in New Zealand primary school play environments: the PLAY Study
Background: In many countries, children and youth are not meeting global physical activity guidelines and while schools are regarded as appropriate settings for increasing physical activity, it remains unclear what specific ... -
The Effect of changes in cerebral perfusion pressure and intracranial pressure on the development of cerebral odema
The influence of intracranial pressure, systemic arterial pressure and cerebral perfusion pressure upon the development of vasogenic cerebral oedema is largely unknown. To study their relationship, an osmotic disruption ... -
Skin cancer in IBD patients treated with immunomodulators
Background Both NMSC and IBD primarily manifest in the Caucasian population. Given the predominance of Caucasians in the New Zealand population, and New Zealand’s specific latitude and ozone layer depletion, it is not ... -
Theta Burst Stimulation of the Human Cerebellum
Background Repetitive Transcranial Magnetic Stimulation (rTMS) of the cerebral cortex has been previously applied as a non-invasive therapy for neurological conditions due to its potential to modify cortical excitability ...