Paediatrics and Child Health - Dunedin

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Recent Deposits

Mechanosensing in Bone

Wade, Emma Mary (Thesis, Doctor of Philosophy, 2016)

The human skeleton is continually remodelled to adapt to force under the influence of gravity. Disuse of the skeleton leads to osteopenia whereas increased use leads to bone accrual. The process, by which skeletal cells ...
Assessing Learning, Breathing and Treatment of Respiratory Obstruction During Sleep in School Children: The ALBATROSS Study

Maessen, Sarah Elizabeth (Thesis, Doctor of Philosophy, 2016)

Introduction: Children with enlarged tonsils and/or adenoids are at risk for sleep disordered breathing (SDB), a common disorder in childhood characterised by snoring, choking, and pauses in breathing during sleep. SDB has ...
Declining Intramuscular Newborn Vitamin K Prophylaxis: An Exploration of Parental Decision Making and Influencing Factors

Miller, Hayleigh (Thesis, Bachelor of Medical Science with Honours, 2016)

Objective Newborn infants are at risk of potentially life-threatening vitamin K deficiency bleeding. This is readily prevented with prophylactic vitamin K at birth. In New Zealand, the recommended route of prophylaxis ...
The relationship of sleep consolidation with behaviour, cognition and sensory processing in toddlers

Appleyard, Katie Clare (Thesis, Doctor of Philosophy, 2016)

Purpose: The negative correlates of childhood sleep difficulties have been well documented. However, the effects of such problems on child development are still poorly understood. The aim of the current study was to assess ...
Sleep Problems and Sleep Disordered Breathing in Children

Smith, Laurelle Anna (Thesis, Doctor of Philosophy, 2016)

Introduction. Sleep disturbances in children can result from extrinsic learned behaviours that become poor sleep habits, or they can arise from intrinsically caused disorders that may require medical treatment. Some sleep ...
Variability in neonatal gentamicin administration influencing drug delivery kinetics

Lala, Anita Carol (Thesis, Master of Medical Science, 2016)

Introduction: Intravenous gentamicin is frequently prescribed for the empiric treatment of early-onset sepsis in premature neonates1. The effective delivery of gentamicin may be influenced by infusion rate and flush volume2. ...
Mutations in the WNT mediator, DVL1, cause an osteosclerotic form of Robinow Syndrome

Bunn, Kieran James (Thesis, Bachelor of Medical Science with Honours, 2015)

This project aimed to clinically and biochemically characterise a novel phenotype which we have named Robinow Syndrome – Osteosclerotic type (RS-OS). Robinow Syndrome (RS) is a rare form of mesomelic dwarfism defined by a ...
Psychosocial determinants of glycaemic control in children and adolescents with Type One Diabetes Mellitus

Chae, Matthew (Thesis, Bachelor of Medical Science with Honours, 2015)

Introduction Type 1 Diabetes Mellitus (T1DM) is a chronic life-long condition that commonly presents in children and adolescents. It is a condition that requires close monitoring, as poor management may lead to severe ...
Early Life Risk Factors for Overweight and Obesity in Childhood

Carter, Philippa Jane (Thesis, Doctor of Philosophy, 2015)

Background: Prevalence of childhood overweight and obesity has risen dramatically over the last few decades, suggesting a causative role for environmental factors, including activity, diet and eating behaviours. Objectives: ...
Indicators for congenital anomalies in New Zealand

Oben, Glenda Lynne McQueen (Thesis, Master of Health Sciences, 2015)

Congenital anomalies are amongst the leading causes of fetal and infant mortality and morbidity, yet are not consistently monitored within existing indicators used to assess the health and wellbeing of the New Zealand ...
Sleep disordered breathing in young children: Natural history and relations to academic performance

Luo, Rebekah Pei Ru (Thesis, Doctor of Philosophy, 2015)

Objective: The aims of this current study were to: (i) examine the natural history of snoring and other sleep disordered breathing (SDB) related symptoms from age 3 to 7 years; (ii) examine the concurrent relationship ...
Physical activity in infancy: assessment of an intervention to increase physical activity in infants

Moir, Christine Patricia (Thesis, Doctor of Philosophy, 2014)

Physical activity (PA) in infancy is an under researched area despite the known relevance of PA to health. This thesis combines three distinct studies to achieve a positive contribution to knowledge in the area of PA and ...
Motivational Interviewing for Weight Feedback

Dawson, Anna (Thesis, Doctor of Philosophy, 2014)

Purpose: To determine whether the use of motivational interviewing (MI) to inform parents that their young child was overweight enhanced their engagement in a family-based intervention compared to feedback delivered via ...
The Paediatric Outpatient Coding Pilot Study

Kerr, Neal Alexander Moealia (Thesis, Bachelor of Medical Science with Honours, 2013)

In New Zealand, recent literature would suggest that children with chronic health conditions and disabilities, and their families are in need of greater support. The primary aims of this thesis were to; determine whether ...
The Genetic and Biological Characterisation of Complex Skeletal Diseases

Gray, Mary (Thesis, Doctor of Philosophy, 2013)

Understanding the aetiology of genetic diseases is important for furthering the fields of genetics, biochemistry and medicine. This project utilises microarray and Next Generation Sequencing technology to elucidate the ...
The Genetics of Skeletogenesis

Holman, Sarah Katherine Fay (Thesis, Doctor of Philosophy, 2012)

WTX is a member of a protein family bearing no homology to proteins with known functional domains with in silico analysis, but is of substantial interest because germline and somatic mutations lead to the developmental ...
Sleep Hygiene and Problematic Sleep in Early Childhood

Smith, Laurelle Anna (Thesis, Master of Science, 2012)

Sleep disturbances in young children are a common complaint among parents, and they can disrupt and put strain on not only the child but the entire family. Problematic sleep is seen to affect 20-40% of the paediatric ...
Sleep and the potential of sleep hygiene for weight management in youth

Tan, Evan (Thesis, Doctor of Philosophy, 2011)

The rate and prevalence of childhood obesity and its associated morbidities, such as obstructive sleep apnoea (OSA), is increasing. Sleep disruption due to OSA has been associated with neurobehavioural impairments such as ...
Investigation of a mutation in CYP26B1

Eerens, Yoska (Thesis, Bachelor of Medical Science with Honours, 2011)

Retinoic acid is known to have several important roles in embryonic development, including limb and hindbrain development and has been shown to induce neural tube defects when it is present at teratogenic levels. The CYP26 ...
Measuring the Physical Activity of Children aged 3 to 7 years

Ku, Hsi-Yu (Thesis, Bachelor of Medical Science with Honours, 2011)

Introduction : Obesity has become epidemic throughout the world and is affecting both adults and children. New Zealand children have a high prevalence of being overweight, with estimates varying between 20% and 30%. Sedentary ...