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The effect of alginate lyase on the antibiotic sensitivity of mucoid Pseudomonas aeruginosa biofilms
Bacteria are single celled organisms that can live together in communities called biofilms. These biofilms consist of a structural matrix consisting of polysaccharide gel secreted by the bacteria, with the bacteria living ...
Functional Analysis of Disease-Associated 3’ UTR Variants: the CXCL12β 3’ UTR G801A Polymorphism
In recent years, the previously neglected 3’ untranslated region (UTR) has gained recognition as a critical region in the regulation of gene expression. Numerous studies have been conducted on disease-associated 3’ UTR ...
Vernalization response in Medicago truncatula
Vernalization is the acquisition of the competence to flower upon exposure to prolonged winter cold. The physical conditions that promote vernalization have been analyzed here in the model legume, Medicago truncatula. The ...
An investigation of the coelomic fluid and coelomocytes in a New Zealand sea urchin (Kina) Evechinus chloroticus
Abstract Sea urchins fulfil a vital role as a simple scientific model organism and as such have remained a well-used tool in the study of embryonic development and immunology. Sea urchins are known to be immunologically ...
DNA Copy Number Variation and BRCAx Hereditary Breast Cancer
Breast cancer is the second most deadly cancer for New Zealand (NZ) women aged between 25-75 years. Breast cancer generally exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. ...
Effects of Folic Acid Supplementation on Human Leukocyte DNA Methylation and Gene Expression
Folic acid and natural folates are B group vitamins obtained exclusively from the diet. Biochemically, folate derivatives participate in the transfer of single carbon units, acting as methyl group donors for numerous ...
Role of iron, siderophores and iron regulation in the Epichloё festucae - Lolium perenne symbiosis
Ferric iron-chelating siderophores are produced by microorganisms to compete for and sequester iron, an essential but potentially toxic micronutrient. <i>Epichloё festucae</i>, a filamentous fungus that is mutualistically ...
The X-ray Crystal Structure of Alanine Racemase from Acinetobacter baumannii
Acinetobacter baumannii is an opportunistic Gram-negative bacterium, which is a common cause of hospital acquired infections. Numerous antibiotic resistant strains exist, emphasising the need for developing new antimicrobials. ...
Understanding Batten disease: CLN5 expression in CLN6 deficient ovine neural cultures.
Neuronal Ceroid Lipofuscinoses (NCL) are a group of debilitating and fatal neurodegenerative diseases of childhood resulting from progressive brain atrophy. The human and ovine variant late infantile CLN6 (ceroid lipofuscinosis ...
The investigation for an ovarian cellular clock in mice
The formation of the ovarian follicles and the subsequent recruitment to proceed to ovulation is a complex mechanism involving both local and external signals. Early hormonal unresponsive follicles develop to a mature ...