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Biophysical characterisation of the bacterial chemosensory protein, PscF
In bacteria, movement in response to a chemical stimulus is known as chemotaxis. Chemotaxis is controlled by a class of ligand binding proteins called chemoreceptors and works to bias cell movement towards environments ...
The role of molecular genetic variation and population structure in the genetic improvement of the honeybee, Apis mellifera
Animal breeding has evolved into a highly sophisticated field, making substantial changes to numerous livestock species worldwide. Such changes are largely absent in the Western Honeybee, Apis mellifera. Direct transfer ...
The Epigenetics of Colorectal Cancer
Aberrant DNA methylation patterns are a universal feature of cancer, yet we understand relatively little of the cause and consequence of DNA methylation in the cancer process. Colorectal cancer (CRC) morbidity and mortality ...
The Establishment and Characterisation of Gastric Organoids as a Model for Hereditary Diffuse Gastric Cancer
Cancer is an exceptionally complex disease which requires an appropriately sophisticated model to facilitate its research. Organoids are 3D structures generated from stem cells, which recapitulate a target organ. These ...
Biochemistry and Biophysics of the ASK1-Prdx1 Axis
Peroxiredoxin 1 (Prdx1) is an abundant cytoplasmic human thiol peroxidase. It functions to detoxify reactive oxygen species, in particular, hydrogen peroxide (H2O2). The canonical mechanism of Prdx1 activity involves the ...
Exosome mRNA localisation: Directing mRNA localisation to exosomes
Exosomes are small vesicles containing proteins, miRNAs and mRNAs. Exosomes are secreted and taken up by neighbouring cells and the contents move into the recipient cell, where they are biologically active (e.g. the mRNA ...
The Twilight Zone of Nucleotide Homology
Homology search tools are important for inferring homology in the abundance of genomes currently sequenced. These tools utilise sequence similarity in order to assign a score between two sequences from which homology is ...
Title Characterisation of the amphibian pathogenic fungus Batrachochytrium dendrobatidis supercontig 5
Amphibian species have been experiencing a massive global decline during the past few decades. Chytridiomycosis, caused by the chytrid fungus Batrachochytrium dendrobatidis (Bd), is a cutaneous infectious disease that leads ...
The PvdF enzyme of Pseudomonas aeruginosa
Pseudomonas aeruginosa is an opportunistic bacterium which requires iron for growth and survival. Under iron limiting conditions, P.aeruginosa secrete iron scavenging compounds called pyoverdines. Pyoverdines consist of a ...
Investigating How Mutations in Cytochrome c Affect the Intrinsic Apoptosis Pathway
Cytochrome c is a highly conserved, haem containing protein that usually resides in the mitochondria inter-membrane space. In mitochondria, cytochrome c has a well-known role in the electron transport chain transferring ...