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Biochemistry collection
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Recent Deposits
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(Thesis, Doctor of Science, 2017)Reconstructing the evolutionary history of our species has traditionally been the purview of archeology and linguistics, but is now increasingly influenced by genetics. However, the information held in our DNA cannot be ... -
(Thesis, Doctor of Philosophy, 2017)The excitatory projection neurons (PNs) of the cortex encode the messages that are critical for mediating higher cognitive function. In the primary motor cortex (M1) PNs integrate signals, which regulate sensory driven and ...
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(Thesis, Master of Science, 2017)The Arthropods are diverse and vary extensively in their form, function and life history strategies. Some of the apparent variation is likely to be due to how different species control their development through the evolution ... -
(Thesis, Master of Science, 2017)Cells have elaborate responses to cues provided to them. Hydrogen peroxide (H2O2) is often produced as a second messenger in response to various growth factors binding to their receptors. Cells contain a range of peroxidases ...
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(Thesis, Master of Science, 2017)The first naturally occurring mutation identified in the highly conserved cytochrome c protein was discovered in a New Zealand family. The missense mutation,\results in the substitution of glycine for serine at residue 41 ...
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(Thesis, Master of Science, 2017)Hsp70s are the most well conserved protein family known, and yet little of their activity within the cell is understood. Hsc70 is a constitutively expressed member of the Hsp70 family found in the cytosol of almost all ... -
(Thesis, Master of Science, 2017)Myalgic Encephalomyelitis (ME) is a complex disease which affects many different body systems. Disturbance of the immune system, brain and central nervous systems cardiac function, dysregulation of metabolism generally ...
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(Thesis, Master of Science, 2017)Copy number variation (CNV) is a common feature of eukaryotic genomes, and a growing body of evidence suggests that genes affected by CNV are enriched in processes associated with environmental responses. Traditionally, ... -
(Thesis, Master of Science, 2017)Trichoderma is a ubiquitous, culturable genus of soil-borne fungi. Many species in the Trichoderma genus possess the ability to colonise plant roots and form mutualistic endophytic relationships. In particular, Trichoderma ...
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(Thesis, Master of Science, 2017)Itch is an E3 ubiquitin-protein ligase that is an important negative regulator of inflammatory signalling, the viral immune response, and controls aspects of cellular differentiation and membrane-receptor sorting. Through ...
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(Thesis, Doctor of Philosophy, 2016)Introns are transcribed non-coding sequences found in every eukaryote, which are spliced out of the transcript during and following transcription. The position and sequence of an intron can increase mRNA and protein levels ... -
(Thesis, Master of Science, 2016)Abstract The occurrence of Alzheimer’s disease (AD) is expected to quadruple by 2050. Currently, there is no treatment that cures or prevents the disease, thereby highlighting the necessity of developing a prophylactic ... -
(Thesis, Doctor of Philosophy, 2016)Alzheimer’s disease (AD) is neurodegenerative disease that mainly occurs in the aging population. It manifests itself as dementia, which is a term that describes a range of behavioural changes such as memory loss, cognitive ...
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Cytoskeletal and mitotic partners for synthetic lethal targeting of E-cadherin-deficient carcinoma (Thesis, Master of Science, 2016)Hereditary diffuse gastric cancer (HDGC) is the familial predisposition to poorly-differentiated, diffuse gastric adenocarcinoma. It is inherited in an autosomal dominant manner and shows high penetrance for diffuse gastric ... -
(Thesis, Doctor of Philosophy, 2016)The covalent attachment of ubiquitin to substrate proteins, a process known as ubiquitylation, is a post-translational modification that modulates protein degradation and cell signalling pathways. A tightly regulated ...
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(Thesis, Master of Science, 2016)Oestrogen receptor α (ERα) positive breast cancer is the most prevalent form of breast cancer diagnosed. While a number of therapeutics have been developed targeting the dependence of these cancers on oestrogen for the ... -
(Thesis, Master of Science, 2016)Elevated plasma levels of lipoprotein(a) [Lp(a)] are a significant genetic risk factor for the development of cardiovascular disease. Plasma Lp(a) levels are primarily modulated via a unique size polymorphism within the ...
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(Thesis, Doctor of Philosophy, 2016)Lipoprotein(a) (Lp(a)) comprises a low density lipoprotein (LDL) particle with one molecule of apolipoprotein B-100 (apoB-100) and one molecule of apolipoprotein(a) [apo(a)], a protein evolutionary derived from plasminogen. ...
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(Thesis, Doctor of Philosophy, 2016)Gout is a complex human disease characterised by attacks of extreme, debilitating pain followed by asymptomatic periods of indeterminate length. Within New Zealand gout is a serious health issue. Approximately 7% of New ... -
(Thesis, Doctor of Philosophy, 2016)Thrombocytopenia Cargeeg is a rare autosomal dominant disorder identified in a New Zealand family with low platelet counts. It is caused by a heterozygous mutation (G41S) in the CYCS gene, which encodes for cytochrome c ...
