Biochemistry collection
Recent Deposits
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Chemotaxis and inhibition of the kauri killer, Phytophthora agathidicida
Phytophthora are devastating pathogens which cause diseases in thousands of economically and ecologically important plants worldwide. Often referred to as 'fungus-like', Phytophthora are a genus of eukaryotic oomycetes. ... -
Introducing CRISPR/Cas9 into the kiwifruit pathogen Pseudomonas syringae pv. actinidiae (Psa)
Pseudomonas syringae pv. actinidiae (Psa) is an emerging bacterial pathogen of kiwifruit, a major primary export of New Zealand. The emergence of Psa in New Zealand in 2010 caused immense financial grief with the disease ... -
Investigating the regulation of Arkadia activity in cells
Ubiquitylation is a post translational modification the regulates a wide variety of cellular processes. The attachment of ubiquitin onto a substrate requires the activity of three enzymes; E1, E2 and E3. As ubiquitylation ... -
Association of Polynesian-specific variants of PRPSAP1 and SLC22A3 genes with gout.
Gout is a complex disease caused by over-production and/or under-excretion of urate, which causes hyperuricaemia. This leads to urate deposition, and initiates the formation of monosodium urate (MSU) crystals in joints and ... -
Characterisation of Plant Cysteine Dioxygenase
Many organisms possess a non-heme, mononuclear iron enzyme termed cysteine dioxygenase (CDO) that aids in homeostasis. This enzyme irreversibly adds molecular oxygen to the thiol group of the N-terminal cysteine residue ... -
Engineering quorum-quenching enzymes
Biofilms are structured communities of bacteria that adhere to surfaces and shield bacteria from hostile surroundings. They are implicated in 75% of all infections in humans and are difficult to treat. New therapies are ... -
Ice activities in New Zealand Chionochloa species
Overwintering plants produce ice active agents with low thermal hysteresis but a higher ability to inhibit the recrystallization of ice crystals already formed. Many plants also minimize the damage from freezing by triggering ... -
Hybrid Assembly of the Chytrid Genome - Insights into the Evolution and Outbreak of a Major Amphibian Pathogen
Devastating amphibian population declines have been observed globally for the last 40 years. These declines have become the interest of several conservationists and researchers, as amphibians form a valuable part of global ... -
The regulation of ascorbate in apples (Malus domestica)
Ascorbate is an essential biochemical for biological processes in plants and animals. Ascorbate concentrations vary greatly between closely related species of plants, and can even differ across cultivars of the same species. ... -
Characterisation of the ubiquitin E3 ligase COP1
Constitutive photomorphogenic 1 (COP1) is a ubiquitin E3 ligase that has been implicated in development of a variety cancers. The goal was to characterise the ubiquitin E3 ligase activity of COP1 and the relationship between ... -
The Development of Circulating Tumour DNA as a Clinical Surveillance Tool for New Zealand Breast Cancer Patients
Breast cancer is a heterogeneous group of diseases where metastatic spread is the major cause of death. Surveillance of treatment response and tumour burden is currently achieved with periodic medical imaging over the ... -
Understanding the Batten disease associated protein CLN5
The neuronal ceroid lipofuscinoses (NCL, Batten disease) are a group of inherited neurodegenerative lysosomal storage diseases (LSD) that typically result in loss of vision, epilepsy, loss of motor function and cognitive ... -
Synergistic Synthetic Lethal Drug Combinations for E-Cadherin-Deficient Cancers
E-cadherin is a cell-to-cell adhesion protein encoded by the gene CDH1. Germline inactivating mutations in CDH1 underpin hereditary diffuse gastric cancer (HDGC), an autosomal dominant disease that strongly ... -
Genetic Predisposition to Gastric Cancer: CDH1 and Beyond
Gastric cancer is a complex disease influenced by strong genetic and environmental factors. Hereditary gastric cancer syndromes are thought to account for between 1-3% of all cases. The most common hereditary gastric cancer ... -
A Synthetic Lethal Approach to the Development of Novel Cancer Therapies
The cell-cell adhesion protein E-cadherin (CDH1) is a tumour suppressor that is required to maintain cell adhesion, cell polarity and cell survival signalling. Somatic mutations in CDH1 are common in diffuse gastric cancer ... -
Comprehensive molecular analysis of different classes of molecules in a Myalgic Encephalomyelitis/Chronic Fatigue Syndrome pilot study group, and investigation of RNA-activated Protein Kinase R (PKR) as a diagnostic biomarker
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a prevalent but poorly understood illness characterised by severe debilitating fatigue, affecting approximately 1 % of the global population and disproportionately ... -
Investigating Disease Processes in CLN5 and CLN6 Batten Disease
The neuronal ceroid lipofuscinoses (NCL, Batten disease) are a heterogeneous group of inherited neurodegenerative disorders, clinically characterised by blindness, myoclonic epilepsy, cerebral atrophy, and progressive ... -
Investigating the role of peroxiredoxin in hydrogen peroxide signalling
Hydrogen peroxide (H2O2) was viewed as an unwanted by-product of aerobic respiration for many years but it is now well-established as being involved in many different signalling pathways. H2O2 is reduced to water by ... -
The role of the low-molecular-weight proteins of the CP43 pre-assembly complex of Photosystem II
The biogenesis of Photosystem II (PS II) involves the stepwise assembly of the reaction centre subcomplex together with the subsequent addition of the two chlorophyll-binding core antenna proteins, CP43 and CP47. In this ... -
Gout and Metabolic Disease: Investigation of Potential Relationship in the New Zealand Population
Hyperuricaemia, pathologically defined as the presence of higher levels of serum urate, results from a compromise in the delicate balance between the production and excretion of urate primarily in the liver and the kidneys, ...