Biochemistry collection
Recent Deposits
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Understanding the Batten disease associated protein CLN5
The neuronal ceroid lipofuscinoses (NCL, Batten disease) are a group of inherited neurodegenerative lysosomal storage diseases (LSD) that typically result in loss of vision, epilepsy, loss of motor function and cognitive ... -
Synergistic Synthetic Lethal Drug Combinations for E-Cadherin-Deficient Cancers
E-cadherin is a cell-to-cell adhesion protein encoded by the gene CDH1. Germline inactivating mutations in CDH1 underpin hereditary diffuse gastric cancer (HDGC), an autosomal dominant disease that strongly ... -
Genetic Predisposition to Gastric Cancer: CDH1 and Beyond
Gastric cancer is a complex disease influenced by strong genetic and environmental factors. Hereditary gastric cancer syndromes are thought to account for between 1-3% of all cases. The most common hereditary gastric cancer ... -
A Synthetic Lethal Approach to the Development of Novel Cancer Therapies
The cell-cell adhesion protein E-cadherin (CDH1) is a tumour suppressor that is required to maintain cell adhesion, cell polarity and cell survival signalling. Somatic mutations in CDH1 are common in diffuse gastric cancer ... -
Comprehensive molecular analysis of different classes of molecules in a Myalgic Encephalomyelitis/Chronic Fatigue Syndrome pilot study group, and investigation of RNA-activated Protein Kinase R (PKR) as a diagnostic biomarker
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a prevalent but poorly understood illness characterised by severe debilitating fatigue, affecting approximately 1 % of the global population and disproportionately ... -
Investigating Disease Processes in CLN5 and CLN6 Batten Disease
The neuronal ceroid lipofuscinoses (NCL, Batten disease) are a heterogeneous group of inherited neurodegenerative disorders, clinically characterised by blindness, myoclonic epilepsy, cerebral atrophy, and progressive ... -
Investigating the role of peroxiredoxin in hydrogen peroxide signalling
Hydrogen peroxide (H2O2) was viewed as an unwanted by-product of aerobic respiration for many years but it is now well-established as being involved in many different signalling pathways. H2O2 is reduced to water by ... -
The role of the low-molecular-weight proteins of the CP43 pre-assembly complex of Photosystem II
The biogenesis of Photosystem II (PS II) involves the stepwise assembly of the reaction centre subcomplex together with the subsequent addition of the two chlorophyll-binding core antenna proteins, CP43 and CP47. In this ... -
Gout and Metabolic Disease: Investigation of Potential Relationship in the New Zealand Population
Hyperuricaemia, pathologically defined as the presence of higher levels of serum urate, results from a compromise in the delicate balance between the production and excretion of urate primarily in the liver and the kidneys, ... -
A Bioinformatics Approach to Synthetic Lethal Interactions in Cancer with Gene Expression Data
Introduction Synthetic lethal genetic interactions are re-emerging as an important concept in the post-genomics era due to their potential for use in precision medicine against cancers. Synthetic lethal drug design ... -
Body Mass Index and Pathway Dysregulation in Cancer
Obesity has been a major global problem for more than a decade, associated with many noncommunicable diseases such as cancer. The number of obese people, both adults and children, has risen in every country of the world ... -
Fats, tumours and survival: Investigating the prognostic association of fatty acid oxidation in breast cancer
Over the past 15 years, a number of prognostic and treatment predictive signatures for breast cancer have been reported and utilised in the clinic. These signatures, for most part, are dominated by genes that reflect tumour ... -
Voluntary oral dosing of cannabidiol for the treatment of Batten Disease
Batten disease, or NCL (neuronal ceroid lipofuscinosis), is a collection of 13 pathologically similar, genetically distinct, autosomal recessive, neurodegenerative lysosomal storage diseases. Primarily affecting children ... -
Investigation of peroxidase activity of human cytochrome c mutants
The textbooks of biochemistry have painted a picture of cytochrome c only being involved in the electron transfer chain for 100 years, but the mitochondrial haem protein also plays important roles in the intrinsic apoptosis ... -
Engineering the activities and specificities of a glycerol dehydratase and an alcohol dehydrogenase
There is growing interest in finding renewable, environmentally friendly routes to chemicals that are traditionally derived from crude oil. The use of bacteria as living factories for the biosynthesis of these chemicals ... -
Functional Conservation Of The Male Germ-line Regulator DUO1 In Flowering Plants
In flowering plants the development of the male germ-line in pollen to form two functional sperm cells is essential for reproduction. DUO1 an R2R3 MYB transcription factor plays a key role in regulating genes required for ... -
Developing peptidomimetics of secreted amyloid precursor protein-alpha (sAPPα) that confer neuroprotection and stimulate novel protein synthesis
FDA drug approval process takes years to reach manufacturing, development is 2-10 years, pre-clinical treatment another 3-6, clinical trails 6-7 years and finally FDA review, another 1-2 years. This a long process due to ... -
Phenotypic and Molecular Analysis of the Alanine and Glutamate Racemases of Mycobacteria
The enzymes alanine racemase (Alr) and glutamate racemase (MurI) catalyze the formation of the essential building blocks, D-alanine and D-glutamate, respectively, for cell wall biosynthesis. Despite their essential cellular ... -
Regulation of Zn2+ and aggregation affects Aβ1-42- induced changes in cell culture viability.
In the story of the pathogenesis of Alzheimer’s Disease, Amyloid-Beta (Aβ) is believed to play a key role. However, evidence suggests that metal ions, in particular Zn2+, may have strong modulatory, or even causative effects ... -
Translational regulation of vitamin C production in plants
Ascorbate is an essential biochemical for plants and animals, as it a powerful antioxidant and an enzyme co-factor. In higher plants, ascorbate is synthesised via the Smirnoff-Wheeler pathway, which is primarily regulated ...