Biochemistry collection
Recent Deposits
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Investigating a putative neuroprotective pathway in Alzheimer’s disease.
Alzheimer’s disease is a debilitating neurological disorder, the worldwide cost of which has recently entered into the trillions of dollars ($USD) per annum. The primary cause of Alzheimer’s disease is believed to be the ... -
Targeted mutagenesis to investigate the role of low-molecular-weight proteins and a bicarbonate cofactor on the assembly and function of Photosystem II
Photosystem II (PS II) catalyses the oxidation of water at ambient temperatures and the formation of plastoquinol using light. This multisubunit complex functions as a dimer, each monomer is surrounded by 13 low-molecular-weight ... -
Candidate Compounds for the Chemoprevention of Hereditary Diffuse Gastric Cancer
Hereditary diffuse gastric cancer (HDGC) is a cancer syndrome caused by germline mutations in the tumour suppressor gene CDH1, which encodes the cell-cell adhesion protein E-cadherin. Mutations in CDH1 lead to increased ... -
uORF-mediated translational regulation of drought stress response gene MASP1 in Arabidopsis thaliana
Human-induced climate variability can subject global regions to water scarcity, prompting widespread crop failure. This calls for innovations that preserve global food security that do not further contribute to climate ... -
Exploring the protein universe: a study of subdomain driven evolution
Even a relatively short polypeptide of 75 amino acids has more unique sequence possibilities than the number of atoms in the observable universe. Given the vastness of this protein sequence space, the fraction of this space ... -
Characterising the Functional and Molecular Determinants for Organ Selective Metastasis in Triple Negative Breast Cancer
Triple-negative breast cancer (TNBC) accounts for 10-20% of primary invasive breast cancer diagnoses, globally. With a higher risk of developing visceral and brain metastasis than other breast cancer subtypes, and limited ... -
Engineering of bacterial chemoreceptors
Many motile bacteria are able to swim towards certain chemicals and are repelled by others. This process is called chemotaxis and is intimately linked with growth and survival, as it directs bacteria towards favorable ... -
Regulation of Iron Uptake Systems in Pseudomonas aeruginosa
Pseudomonas aeruginosa requires iron for growth and metabolism, but is able to grow in environments where bioavailable iron is scarce. As such, the bacteria must scavenge iron from their environment using a variety of iron ... -
Do genetic variants in the TLR4 promoters and role of innate immune system play a role in gout susceptibility?
Gout is a form of inflammatory arthritis caused by the deposition of monosodium urate crystals in the joints as a result of hyperuricemia and subsequent innate immune response. Proteins encoded by Toll-like receptor 4 ... -
Using targeted mutagenesis to investigate the role of the bicarbonate ligated to the non-heme iron of Photosystem II
Photosystem II (PS II) is a photochemical oxidoreductase enzyme capable of splitting water and initiating photosynthesis. Photosystem II functions by removing electrons from water, and transferring them via a series of ... -
Disrupting Pseudomonas aeruginosa quorum sensing
Many clinically relevant bacteria use a population-dependent communication network - known as quorum sensing - to regulate the processes essential for the establishment of infections. Quorum sensing enables pathogens to ... -
Ubiquitylation by TRAF RING heterodimers: Complexity in TRAF-mediated signalling
Ubiquitylation, one of the most abundant post-translational modification in cells, is regulated by a cascade of enzymes (E1, E2 and E3 ligases). E3 ligases, along with their partner E2 enzymes, catalyse the final step of ... -
The effect of removing PsbJ in Synechocystis sp. PCC 6803 mutants that lack the extrinsic proteins of Photosystem II
Photosystem II (PS II) is the light-driven water-plastoquinone oxidoreductase of photosynthesis. PS II consists of 20 protein subunits including four core complexes forming the reaction centre, 13 additional low-molecular-weight ... -
Investigation of ubiquitin transfer by RING E3 ligases RNF121 and RNF114
Ubiquitylation is a post-translational modification that modulates protein turnover, function and localisation. The attachment of ubiquitin is achieved by a sophisticated enzyme cascade. Specificity is provided by E3 ... -
The regulation of ascorbate accumulation in plants
Ascorbate (Vitamin C) is vital to human health. We are unable to synthesise ascorbate and attain the majority of ascorbate from plants. Ascorbate accumulation is a complex, regulated and environmentally responsive trait ... -
Characterisation of a new role for the UBA domain in ubiquitin chain synthesis by Ube2K
Ubiquitylation is a post-translational modification in which the protein Ubiquitin (Ub) is attached to other proteins, dictating their fate. Ubiquitylation requires the action of three groups of enzymes, Ub activating (E1) ... -
The involvement of the multiple drug resistance family in facial eczema resistance
Facial Eczema (FE) is a disease of ruminants that was first reported in New Zealand at the beginning of this century. Today this disease is considered the most important mycotoxin affecting the sheep industry, causing an ... -
Investigating How Mutations in Cytochrome c Affect the Intrinsic Apoptosis Pathway
Cytochrome c is a highly conserved, haem containing protein that usually resides in the mitochondria inter-membrane space. In mitochondria, cytochrome c has a well-known role in the electron transport chain transferring ... -
The PvdF enzyme of Pseudomonas aeruginosa
Pseudomonas aeruginosa is an opportunistic bacterium which requires iron for growth and survival. Under iron limiting conditions, P.aeruginosa secrete iron scavenging compounds called pyoverdines. Pyoverdines consist of a ... -
Title Characterisation of the amphibian pathogenic fungus Batrachochytrium dendrobatidis supercontig 5
Amphibian species have been experiencing a massive global decline during the past few decades. Chytridiomycosis, caused by the chytrid fungus Batrachochytrium dendrobatidis (Bd), is a cutaneous infectious disease that leads ...