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Mechanisms of Hereditary Diffuse Gastric Cancer Initiation: The role of E-cadherin in the Epithelial-Mesenchymal Transition
Hereditary diffuse gastric cancer (HDGC) is a dominantly inherited cancer syndrome caused by germline mutations in the CDH1 gene which encodes the calcium-dependent, cell-cell adhesion protein E-cadherin [1,2]. Early stage ...