Thrombocytopenia Cargeeg is a rare autosomal dominant disorder identified in a New Zealand family with low platelet counts. It is caused by a heterozygous mutation (G41S) in the CYCS gene, which encodes for cytochrome c ...

Neuronal Ceroid Lipofuscinoses (NCL) are a group of debilitating and fatal neurodegenerative diseases of childhood resulting from progressive brain atrophy. The human and ovine variant late infantile CLN6 (ceroid lipofuscinosis ...

Vernalization is the acquisition of the competence to flower upon exposure to prolonged winter cold. The physical conditions that promote vernalization have been analyzed here in the model legume, Medicago truncatula. The ...

Abstract Sea urchins fulfil a vital role as a simple scientific model organism and as such have remained a well-used tool in the study of embryonic development and immunology. Sea urchins are known to be immunologically ...

Breast cancer is the second most deadly cancer for New Zealand (NZ) women aged between 25-75 years. Breast cancer generally exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. ...

The covalent attachment of ubiquitin to substrate proteins (ubiquitylation) is a post-translational modification that has major roles in regulating protein turnover and cell signalling. An E1-E2-E3 enzyme cascade tightly ...

Abstract Background: Given the importance of iron in human health, surprisingly there are many gaps in our knowledge of how cells can rapidly respond to changes in extracellular iron levels. There is a lack of research ...

Elevated plasma levels of lipoprotein(a) [Lp(a)] are a significant genetic risk factor for the development of cardiovascular disease. Plasma Lp(a) levels are primarily modulated via a unique size polymorphism within the ...

Ruminant milk whey, a by-product of cheese manufacture, is known to contain a large number of proteins. Bovine cheese whey at present is mostly used as nutritional supplements due to its high protein content, while non-bovine ...

Heat shock protein 70 (Hsp70) is an important molecular chaperone of the proteostasis network, mediating protein folding and stability. Malfunction of proteostasis contributes to diseases as diverse as cancer and Alzheimer’s. ...