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    Investigations into a cytochrome c variant that causes thrombocytopenia 

    Ong, Lily Chin Chin
    Thrombocytopenia Cargeeg is a rare autosomal dominant disorder identified in a New Zealand family with low platelet counts. It is caused by a heterozygous mutation (G41S) in the CYCS gene, which encodes for cytochrome c ...
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    Understanding Batten disease: CLN5 expression in CLN6 deficient ovine neural cultures. 

    McIntyre, Kristina
    Neuronal Ceroid Lipofuscinoses (NCL) are a group of debilitating and fatal neurodegenerative diseases of childhood resulting from progressive brain atrophy. The human and ovine variant late infantile CLN6 (ceroid lipofuscinosis ...
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    Vernalization response in Medicago truncatula 

    Jaudal, Mauren Cali
    Vernalization is the acquisition of the competence to flower upon exposure to prolonged winter cold. The physical conditions that promote vernalization have been analyzed here in the model legume, Medicago truncatula. The ...
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    An investigation of the coelomic fluid and coelomocytes in a New Zealand sea urchin (Kina) Evechinus chloroticus 

    Wicky, Christopher James
    Abstract Sea urchins fulfil a vital role as a simple scientific model organism and as such have remained a well-used tool in the study of embryonic development and immunology. Sea urchins are known to be immunologically ...
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    DNA Copy Number Variation and BRCAx Hereditary Breast Cancer 

    Coufal, Nicole Jessica
    Breast cancer is the second most deadly cancer for New Zealand (NZ) women aged between 25-75 years. Breast cancer generally exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. ...
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    Ubiquitin transfer by the Arkadia and Ark2C RING domains 

    Wright, Joshua
    The covalent attachment of ubiquitin to substrate proteins (ubiquitylation) is a post-translational modification that has major roles in regulating protein turnover and cell signalling. An E1-E2-E3 enzyme cascade tightly ...
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    A rapid response to iron in human cells 

    Wardell, Samuel Joseph Taylor
    Abstract Background: Given the importance of iron in human health, surprisingly there are many gaps in our knowledge of how cells can rapidly respond to changes in extracellular iron levels. There is a lack of research ...
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    Next Generation Sequencing of the KIV2 Domain of LPA 

    Brown, Aimee Nicole
    Elevated plasma levels of lipoprotein(a) [Lp(a)] are a significant genetic risk factor for the development of cardiovascular disease. Plasma Lp(a) levels are primarily modulated via a unique size polymorphism within the ...
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    Ruminant Milk Whey Proteome in Nutraceutical Research and Development 

    Ha, Minh
    Ruminant milk whey, a by-product of cheese manufacture, is known to contain a large number of proteins. Bovine cheese whey at present is mostly used as nutritional supplements due to its high protein content, while non-bovine ...
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    2.8 Å Structure of an ATP-bound Hsp70 from Escherichia coli 

    Gommans, Aimée Louise
    Heat shock protein 70 (Hsp70) is an important molecular chaperone of the proteostasis network, mediating protein folding and stability. Malfunction of proteostasis contributes to diseases as diverse as cancer and Alzheimer’s. ...
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