Thrombocytopenia Cargeeg is a rare autosomal dominant disorder identified in a New Zealand family with low platelet counts. It is caused by a heterozygous mutation (G41S) in the CYCS gene, which encodes for cytochrome c ...

Alzheimer’s Disease is a neurodegenerative condition with progressively worsening memory and cognitive function, which ultimately results in death. The two major neuropathological hallmarks of AD are extracellular amyloid-beta ...

Homing endonucleases are highly specific DNases, commonly called HEGs, encoded by self-splicing intein and intron sequences. They recognise long target sequences and confer mobility to their host sequence by introducing a ...

Molecular chaperone proteins play a pivotal role in maintaining normal proteostasis within the cell by aiding the correct folding of nascent chains. Understanding how these proteins function, has implications for a milieu ...

Neuronal Ceroid Lipofuscinoses (NCL) are a group of debilitating and fatal neurodegenerative diseases of childhood resulting from progressive brain atrophy. The human and ovine variant late infantile CLN6 (ceroid lipofuscinosis ...

The PsbT subunit of photosystem II (PSII) is a single α-helical trans-membrane protein found at the monomer-monomer interface of PSII dimers. During oxygen evolution by PSII in the cyanobacterium Synechocystis sp. PCC 6803, ...

Vernalization is the acquisition of the competence to flower upon exposure to prolonged winter cold. The physical conditions that promote vernalization have been analyzed here in the model legume, Medicago truncatula. The ...

Abstract Sea urchins fulfil a vital role as a simple scientific model organism and as such have remained a well-used tool in the study of embryonic development and immunology. Sea urchins are known to be immunologically ...

In forensic investigations the distinction between expirated bloodstains (blood from the mouth, nose or lungs) and impact spatter (blood from gunshots, explosives, blunt force trauma and/or machinery accidents) is often ...

Breast cancer is the second most deadly cancer for New Zealand (NZ) women aged between 25-75 years. Breast cancer generally exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. ...