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Investigations into a cytochrome c variant that causes thrombocytopenia
Thrombocytopenia Cargeeg is a rare autosomal dominant disorder identified in a New Zealand family with low platelet counts. It is caused by a heterozygous mutation (G41S) in the CYCS gene, which encodes for cytochrome c ...
Gene therapy for Alzheimer's disease: Characterising lentivirus and adeno-associated virus spread from the adult mouse hippocampus
Alzheimer’s Disease is a neurodegenerative condition with progressively worsening memory and cognitive function, which ultimately results in death. The two major neuropathological hallmarks of AD are extracellular amyloid-beta ...
Analysis of fungal inteins
Homing endonucleases are highly specific DNases, commonly called HEGs, encoded by self-splicing intein and intron sequences. They recognise long target sequences and confer mobility to their host sequence by introducing a ...
A probing tail of our molecular chaperones
Molecular chaperone proteins play a pivotal role in maintaining normal proteostasis within the cell by aiding the correct folding of nascent chains. Understanding how these proteins function, has implications for a milieu ...
Understanding Batten disease: CLN5 expression in CLN6 deficient ovine neural cultures.
Neuronal Ceroid Lipofuscinoses (NCL) are a group of debilitating and fatal neurodegenerative diseases of childhood resulting from progressive brain atrophy. The human and ovine variant late infantile CLN6 (ceroid lipofuscinosis ...
Characterisation of the role of the PsbT subunit in photosystem II in Synechocystis sp. PCC 6803
The PsbT subunit of photosystem II (PSII) is a single α-helical trans-membrane protein found at the monomer-monomer interface of PSII dimers. During oxygen evolution by PSII in the cyanobacterium Synechocystis sp. PCC 6803, ...
Vernalization response in Medicago truncatula
Vernalization is the acquisition of the competence to flower upon exposure to prolonged winter cold. The physical conditions that promote vernalization have been analyzed here in the model legume, Medicago truncatula. The ...
An investigation of the coelomic fluid and coelomocytes in a New Zealand sea urchin (Kina) Evechinus chloroticus
Abstract Sea urchins fulfil a vital role as a simple scientific model organism and as such have remained a well-used tool in the study of embryonic development and immunology. Sea urchins are known to be immunologically ...
Forensic Analysis of Expirated blood
In forensic investigations the distinction between expirated bloodstains (blood from the mouth, nose or lungs) and impact spatter (blood from gunshots, explosives, blunt force trauma and/or machinery accidents) is often ...
DNA Copy Number Variation and BRCAx Hereditary Breast Cancer
Breast cancer is the second most deadly cancer for New Zealand (NZ) women aged between 25-75 years. Breast cancer generally exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. ...