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Investigation of coelomic fluid from the sea urchin E. chloroticus
The oceans of the world cover approximately 71% of the surface of the earth and are a source of food and recreation for billions of people. Humans have a vested interest in monitoring the health of the marine environment. ...
An investigation into the potential use of the histone deacetylase inhibitor, valproic acid for the prevention of gastric cancer in high-risk families
Hereditary diffuse gastric cancer (HDGC) is a cancer syndrome caused by germline mutation of the CDH1 gene that encodes the cell adhesion tumor suppressor protein E-cadherin. Mutation carriers have a lifetime risk higher ...
A search for synthetic lethality between Polo-like Kinase 3 and E- Cadherin
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant condition caused by a mutation in the tumour suppressor gene E-cadherin, (CDH1). It predisposes to a 70% likelihood of developing highly penetrant diffuse ...
Studies On Bacterial Chemoreceptors
Motile bacterial use membrane-embedded chemoreceptor molecules to detect the chemical environment and mediate chemotaxis. Specific compounds are detected at the N-terminal and extracellular ligand-binding domain (LBD), ...
An Intracellular Probe of Hsc70:Substrate Interactions
Hsc70 is a constitutively active member of the heat shock chaperone family. It has many roles in all cell types, including prevention of protein aggregation, uncoating of clathrin vesicles, and involvement in the maturation ...
DISC1 in Psychiatric Illness
Major psychiatric illnesses including bipolar disorder and schizophrenia can be highly debilitating and collectively have a lifetime incidence of approximately 1% in the general population. Twin and adoption studies have ...
Relationship of Gout and Dyslipidemia
Gout is an inflammatory response to monosodium urate (MSU) crystals that may exist asymptomatically for months or years, until the first gout attack occurs. The genetic or biochemical factor/s predisposing certain people ...
On the Evolution of Catalysis: The changing kinetics of core metabolic enzymes
Enzymes are biological catalysts that are essential to life: they are largely very efficient and exquisitely specialised to their substrate. They are, however, predicted to have evolved from simple promiscuous catalysts ...
Statistical Methods for the Analysis of Copy Number Variation
Copy number variation (CNV) is a type of genomic structural variation which has been associated with disease risk in humans and with trait variation in agricultural species. This type of variation has also been implicated ...
A probing tail of our molecular chaperones
Molecular chaperone proteins play a pivotal role in maintaining normal proteostasis within the cell by aiding the correct folding of nascent chains. Understanding how these proteins function, has implications for a milieu ...