Show simple item record

dc.contributor.advisorKerr, Steve
dc.contributor.advisorWise, Lyn
dc.contributor.authorOsborne, Jonathan Robert
dc.date.available2013-04-16T03:49:03Z
dc.date.copyright2013
dc.identifier.citationOsborne, J. R. (2013). Intranasal VEGF-A and VEGF-E in a modified Levine model of stroke (Thesis, Master of Science). University of Otago. Retrieved from http://hdl.handle.net/10523/3894en
dc.identifier.urihttp://hdl.handle.net/10523/3894
dc.description.abstractVEGF (Vascular endothelial growth factor)-A has been shown to successfully enter the brain via the intranasal pathway and improve symptoms following focal ischemia in rats. However VEGF-A promotes inflammation and vascular permeability which are believed to contribute to the damage following stroke. VEGF-E has been shown to produce reduced inflammation and vascular permeability while still stimulating similar levels of angiogenesis. We aimed to compare intranasal VEGF-A and VEGF-E doses in a modified Levine model of stroke. VEGF was delivered on days 3, 4 & 5 following hypoxic ischemia. Infarct was measured on day 14 using cresyl violet stain. Behavioural assessments were performed before hypoxic ischemia and on day 1, 7 and 14. We found that VEGF-A and VEGF-E did not affect behavioural scores or infarct volume. However, VEGF-E (20µg) reduced weight loss at day 14 after stroke. These findings suggest that intranasal VEGF-A and VEGF–E are not effective in the modified Levine model used in this study.
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherUniversity of Otago
dc.rightsAll items in OUR Archive are provided for private study and research purposes and are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectVEGF
dc.subjectstroke
dc.subjectintranasal
dc.subjectischemia
dc.subjectVEGF-E
dc.titleIntranasal VEGF-A and VEGF-E in a modified Levine model of stroke
dc.typeThesis
dc.date.updated2013-04-16T02:56:17Z
dc.language.rfc3066en
thesis.degree.disciplineNeuroscience
thesis.degree.nameMaster of Science
thesis.degree.grantorUniversity of Otago
thesis.degree.levelMasters
otago.openaccessOpen
 Find in your library

Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record