Thesis - Honours
Recent Deposits
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The forgotten arm of the fight-flight response: α-adrenergic control of the diabetic heart and interactions with Calmodulin Kinase 2
In Type 2 Diabetes Mellitus (T2DM) chronic metabolic stress and associated hemodynamic dysregulation result in a two-fold increase in cardiovascular disease (CVD) risk, making CVD a leading cause of death for T2DM patients ... -
Regulation of cardiac ryanodine receptor 2 by protein kinase CK2
The cardiac muscle ryanodine receptor (RyR2) is an intracellular Ca2+ channel responsible for the release of Ca2+ during excitation-contraction coupling. It is also implicated in pathological store-overload-induced Ca2+ ... -
Characterising the relationship between Legionella longbeachae and their amoebal hosts: Implications for Legionnaires' disease prevention
In New Zealand, Legionella longbeachae is the leading cause of Legionnaires’ disease, a severe form of pneumonia that often results in hospitalisation and an intensive course of treatment. Every year, during spring and ... -
Atherogenic Index In Plasma and Risk of Cardiovascular Events
As dyslipidaemia is a prominent CVD risk factor, improvements in its management are crucial, as dyslipidaemia (quantified by hypercholesterolemia and treated with statins), incompletely addresses the residual CVD risk ... -
Arterial Hypertension. Consume Carbon Monoxide?
Epithelial sodium channels (ENaC) are generally responsible for the passive movement of sodium ions through the apical cell membrane of salt absorbing epithelia. Canonical ENaC is composed of three homologous subunits, ... -
Characterisation of Arcuate Nucleus Projections to the Paraventricular Nucleus of Thalamus
The metabolic state (fed or hungry) has been shown to influence varying responses to food-associated cues. Recent studies reveal that the paraventricular nucleus of the thalamus (PVT) may play a critical role as it receives ... -
A Novel Oocyte Cryopreservation Method using High Pressure Freezing
Oocyte cryopreservation (egg freezing) involves freezing a female’s oocytes in order to preserve her fertility. These oocytes can later be thawed and fertilised in vitro when she is ready to begin fertility treatment. Women ... -
Bacterial regulation of early activation of mucosal-associated invariant T (MAIT) cells
Mucosal-associated invariant T (MAIT) cells are a population of CD8+ innate-like T cells that play an important role in the immune response to bacterial infections. Being characterised by the expression of a unique ... -
The α-Adrenergic System and CaMKII in Diabetic Heart Disease
The relationship between diabetes mellitus and heart disease is widely documented, with heart disease being the main cause of mortality in diabetic patients. Diabetes impairs the autonomic nervous system, leading to an ... -
The Role of α-ENaC and δ-ENaC in Breast Cancer Cell Migration
Breast cancer is an important disease worldwide, primarily affecting women, and is the most common and deadliest form of female cancer. This is reflected in New Zealand’s population as breast cancer has high incidence and ... -
Candidate Compounds for the Chemoprevention of Hereditary Diffuse Gastric Cancer
Hereditary diffuse gastric cancer (HDGC) is a cancer syndrome caused by germline mutations in the tumour suppressor gene CDH1, which encodes the cell-cell adhesion protein E-cadherin. Mutations in CDH1 lead to increased ... -
Validation and Characterisation of Novel miRNAs Identified in the E15.5 Mouse Brain
MicroRNAs (miRNAs) are small noncoding elements that downregulate gene expression and play an important role in maintaining robust neurodevelopment. Since abnormal expression of miRNAs has been associated with disorders ... -
uORF-mediated translational regulation of drought stress response gene MASP1 in Arabidopsis thaliana
Human-induced climate variability can subject global regions to water scarcity, prompting widespread crop failure. This calls for innovations that preserve global food security that do not further contribute to climate ... -
Investigation into the relative location of filamin B and YB-1 in cell cycle progression
The cell cycle is a fundamental process in development and the maintenance of homeostasis. Various proteins regulate the cell cycle, such as Y-box binding protein -1 (YB-1). YB-1 transcriptionally regulates cell cycle ... -
Validation and Characterisation of Novel miRNAs Identified in the E15.5 Mouse Brain
MicroRNAs (miRNAs) are small noncoding elements that downregulate gene expression and play an important role in maintaining robust neurodevelopment. Since abnormal expression of miRNAs has been associated with disorders ... -
Effect of WNT/β-catenin Signalling on T cells in Colorectal Cancer
Worldwide, colorectal cancer (CRC) is the fourth most common cancer and has the second highest mortality rate of any cancer. Only a subset of CRC patients respond to immunotherapies. This lack of response may be due to the ... -
Targeted Epigenetic Editing using a dCas9-SunTag Demethylation system
DNA methylation is a stable epigenetic modification, playing a critical role in the regulation of gene expression. Dysregulation of DNA methylation is implicated in the pathogenesis of numerous diseases including cancer. ... -
Gene Modification of Breast Cancer Cells for Cancer Imaging
Human epidermal growth factor receptor 2 (HER2) is a prominent breast cancer cell surface receptor that is overexpressed in approximately 20-30% of breast cancer tumours. Trastuzumab (Herceptin) is an effective clinical ... -
Regulation of Antigen Presenting Cells by Human Papillomavirus Small Extracellular Vesicles
Human Papillomavirus (HPV) causes over 99% of cervical cancer cases in the world, and of these, over 70% of cases can be attributed to high-risk HPV. There are prophylactic vaccines for HPV, that specifically target high-risk ... -
Assessing the efficacy of a fluorescent model of the ovarian reserve in mice
In mammalian females, germ cells proliferate exclusively in development resulting in a finite number of oocytes at birth which are kept in a dormant state within primordial follicles. The ovarian reserve (OR) is the ...