Thesis - Honours
Recent Deposits
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The role of exocyst members sec6 and sec8 in the anterograde trafficking of KCa3.1 to the basolateral membrane of polarised epithelial cells
In epithelia, ion channels play an essential role in maintaining the required electrochemical gradients for the tissue to function. This function can translate to electrolyte and fluid homeostasis which in turn, relies on ... -
BCG impact on Innate Lymphoid Cells: Determining the Site of Proliferation
Tuberculosis (TB) is an infectious lung disease that is a major cause of mortality, causing an estimated 1.7 million deaths globally per year. The current prophylactic vaccine used against TB, bacille Calmette Guérin (BCG), ... -
The role of Numb in honeybee ovary activation
Environmental signals in utero are throught to induce plastic changes to metabolism and gene regulation, causing diseases such as Type 2 Diabetes. For example, fetal undernutrition is associated with obesity, hyperglycemia, ... -
The role of the mTOR-Raptor complex in driving hyperuricemia-induced diabetes mellitus
Elevated serum uric acid (hyperuricemia) when left untreated can lead to a range of pathologies including gout, cancer and type 2 diabetes mellitus (T2DM). It has been shown that after three days of exposure to hyperuricemic ... -
Disarming tissue factor: generating a model tumour antigen
Coagulative abnormalities are a well-recognised feature of malignancy. The risk of developing thrombotic disorders is increased four-fold in cancer patients and more than six-fold higher in those receiving chemotherapy. ... -
Investigating Teixobactin Tolerance in Enterococcus faecalis
The rapid rise of antimicrobial resistance (AMR) poses a global threat to human health. Key to combating antimicrobial resistance will be to increase our understanding of how resistance develops. Conventional antimicrobial ... -
The presence of ∆133p53 and ∆40p53 in metastatic brain tumours: evidence for further enquiries
Metastatic brain tumours are becoming more prevalent as individuals with primary cancers receive improved treatment and live longer. These brain tumours are difficult to treat and are often left undiagnosed. This study ... -
Development of a local protocol and method to measure Beta-Cell Function in individuals with Pre-diabetes and Type 2 Diabetes
Type 2 diabetes mellitus (T2DM) is long-term metabolic disorder characterised by high blood glucose (BG), insulin resistance and poor insulin secretion. T2DM is preceded by pre-diabetes characterised by altered glucose ... -
Hepcidin and Iron Deficiency: Novel Findings for Elite Female Rugby Sevens Players
Iron deficiency (ID), measured via serum ferritin (SF), is a common issue for female athletes due to inadequate dietary iron intakes, menstruation and exercise-induced iron losses. Elite female rugby sevens players are no ... -
Targeted Enrichment and Nanopore Sequencing of RNA Transcripts from Breast Cancer Risk Genes
Aberrant alternative splicing of hereditary breast and ovarian cancer genes has been associated with an increased susceptibility for breast and/or ovarian cancer. However, studying the effects of gene variants on splicing ... -
Characterisation of a phase-variable restriction-modification system in Enterococcus faecalis
The gastrointestinal colonizer Enterococcus faecalis is an opportunistic, multi-drug resistant pathogen and a leading cause of nosocomial infections. Vancomycin- resistant enterococci (VRE) are of particular concern and ... -
Aspirin’s role in preventing E-cadherin cleavage by the carcinogenic Bacteroides fragilis toxin
Carriage of enterotoxigenic Bacteroides fragilis (ETBF) in the colonic mucosa is associated with increased risk of pre-cancerous lesions. Antibiotics will not selectively eradicate these bacteria, but toxin-mediated host ... -
Identification of AH1-specific T cells in a mouse model of colorectal cancer
Colorectal cancer (CRC) causes approximately 1.4 million new cases of disease and 700,000 deaths worldwide annually. To overcome limitations of studying CRC in humans, mouse models are used to test therapeutics such as ... -
Intracellular redox changes during TNFα-mediated necroptosis
Necroptosis is a form of regulated cell death triggered by a variety of factors associated with infection and inflammation. It is distinct from the well-characterised cell death processes of apoptosis and necrosis, sharing ... -
CNVs and familial breast and ovarian cancer
BRCA1 pathogenic variant carriers experience a high risk of developing breast and ovarian cancer, however, differences in risk vary greatly between individuals. The advent of genetic testing has presented an increasing ... -
Identifying the role of connexin 43 in transport of microRNAs
Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Present treatments for CVD rely heavily on surgical interventions and drug therapies that relieve symptoms rather than cure the disease. Therefore, ... -
The Impact of Epithelial Sodium Channel on Breast Cancer Cell Migration
Breast cancer is the most common cancer in New Zealand women, with the majority of breast cancer deaths being due to metastasis. This highlights the importance of identifying regulators and, thus, potential therapeutic ... -
Sodium and Uric Acid as Modulators of Vascular Endothelial ENaC
Hypertension, defined as a chronically high blood pressure, is a significant risk factor for heart attacks and strokes. Despite hypertension affecting 28% of individuals over the age of 20 years old, little is known about ... -
Modulation of Lineage Development in the Colonic Epithelium
Despite being exposed to microbial and food antigens, the human gastrointestinal tract does not exist in a state of inflammation. This homeostasis is critically dependent on the colonic epithelial barrier, which when ... -
Investigating the Effects of Chronic Low-Grade Inflammation on Cancer Immunotherapy
Cancer is the leading cause of death in New Zealand and is responsible for approximately one third of all deaths. Due to various factors, including unhealthy life style choices and an aging population, the number of new ...