Thesis - Honours
Recent Deposits
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'Gathering places' : the mixed descent families of Foveaux Strait and Rakiura/Stewart Island, 1824-1864
[…] This dissertation explores the social world of the mixed descent or 'half caste' population based around Foveaux Strait and Rakiura/Stewart Island up until the purchase of Rakiura by the Crown in 1864. I examine the ... -
Adrenergic stimulation of HK-2 proximal tubular cells in hyperglycaemic conditions
One of the most commonly associated complications of Diabetes Mellitus is nephropathy, with one in five diabetics sustaining renal injury over their lives. Renal denervation has been shown to decrease systemic blood pressure ... -
Dementia and Identity
This thesis explores the multiple ways identity can be affected by dementia. It primarily concerns how ‘personal identity’ is affected in the early to moderate stages of dementia, and secondarily concerns how ‘personhood’ ... -
PKCε Phosphorylation of RyR2: A Novel Link between Diabetes and Arrhythmia.
Cardiovascular disease (CVD) is the leading cause of death in the world. Arrhythmia is a type of CVD which can be caused by store overload induced calcium (Ca2+) release (SOICR) in cardiomyocytes. SOICR occurs ... -
The individual child : study of the development of social services in education in relation to the first Labour government's educational policy
The subject of this study is the effect which the policy of the individual child, as expressed by the Labour Government in 1939, had on the development of social services in education. This development was examined chiefly ... -
Predisposition to Non Alcoholic Fatty Liver Disease in Preterm Guinea Pigs
Background: Preterm birth accounts for ~10% of all births and is now an established risk factor for the development of metabolic syndrome, a cluster of conditions responsible for significant morbidity and mortality in New ... -
Stratigraphy, tectonics, and provenance of rocks in the Wether Hill area, Western Southland
A terrane boundary was mapped between the Murihiku Supergroup and the Takitimu Group in the Wether Hill area, Western Southland. The two terranes (Murihiku and Brook Street) are juxtaposed along the gently eastward-dipping ... -
The geology of the Eastern Saddle Road area, Manawatu, N.I., N.Z.
A segment of the Brookstreet terrain (Coombs et. al., 1976) is described from the Bluff Peninsula, Southlando The basement rocks include Lower-Permian volcanogenic sediments and dykes of the Greenhills Group with interbedded ... -
Murihiku lithology and lithostratigraphy across Beaumont and Ardcross stations, southern Wairaki hills
The area mapped (18kni2), crosses the boundary between the Brook Street terrane of Permian - Early Jurassic age and the Murihiku terrane of Triassic, north of Ohai in western Southland. This study focused on the lithology ... -
The geology of Flat Hill-Ocean Beach, Bluff Peninsula
In the Bluff area lower green schist facies Greenhills Group rocks of the Brook Street terrane derived from a Permian volcanic arc have been intruded by igneous bodies inducing contact metamorphism. Facies of contact ... -
The geology of Bluff Hill, Southland, New Zealand.
The mineralogy and structure of two gabbronorite intrusions forming Bluff Hill, is described. They intrude volcanogenic metasediments of the Greenhills Group and together comprise a segment of Brook Street terrane (Coombs ... -
Measuring Markers of Immune Response in Patients Treated with Nivolumab (Opdivo®) and Pembrolizumab (Keytruda®)
Immune checkpoint inhibitors (ICIs) have drastically improved the clinical outcome for many cancer patients. However, not all patients treated with ICIs show a clinical response and the development of a unique spectrum of ... -
Investigating the Site of Innate Lymphoid Cell Division Following BCG Vaccination
Tuberculosis (TB) is the most deadly infectious disease worldwide, killing 1.4 million people each year. Efforts to control the spread of this disease through antibiotic treatments and a century-old preventative vaccine, ... -
Influence of the p53 isoform, delta133p53, on cytoskeletal dynamics during the initiation of migration
The well-known tumour suppressor p53 is known to prevent the development of tumours. Recent research has highlighted the importance of an N-truncated isoform, Δ133p53, in the progression of metastatic cancers. This particular ... -
Identification of Transporters Involved in Drug-drug Interactions During Gout Treatment in Primary Rat Hepatocytes
Gout is one of the most common form of inflammatory arthritis, with hyperuricemia as the major risk factor. Chronic hyperuricemia, or high level of serum uric acid (SUA), can lead to the formation of monosodium urate ... -
The effect of the trafficking protein p11 on the epithelial sodium channel
Regulation of renal sodium (Na+) excretion is crucial for the maintenance of extracellular salt and volume homeostasis and thus for blood pressure control. The epithelial sodium channel (ENaC) is composed of three subunits; ... -
Determining the best combination of TLR Agonist and Tumour Peptide for Cancer Vaccination
Immunotherapy has revolutionised the treatment of cancer in recent years; significantly improving patient response and long-term survival. Though many immunotherapies focus on increasing the effector function of immune ... -
Lhx9 is required for urogenital ridge development and ovarian function
While there has been extensive research into the differentiation of sexually dimorphic gonads, there is much to learn about the bi-potential structure they arise from, the urogenital ridge (UGR). This gap in knowledge is ... -
Exploring the Different CaMKII Isoforms in the Vasculature
Coronary artery disease continues to be the leading cause of mortality in the world and a major source of disability, particularly for the aged population. The presence of vascular diseases such as atherosclerosis is a ... -
Ageing Astrocytes - Implications for Motoneuron Dysfunction and Sarcopenia
Sarcopenia: The most conspicuous intractable feature of advancing age is the gradual loss of skeletal muscle mass and the resultant loss of strength and mobility, and this is a major driver of morbidity and mortality in ...