Thesis - Honours
Recent Deposits
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Advanced Meta-Analysis and Bariatric Surgery
Background: Obesity is one the most important public health concerns worldwide. Randomised clinical trials (RCT) have compared the various bariatric techniques and these have been incorporated in several meta-analyses and ... -
Rational Reflection and An Integrative Account of Moral Cognition
This thesis is about the relationship between the brain and morality. In the last two decades there has been a rapid growth in the neuroscience and psychology of morality, such that a new a field has emerged called “moral ... -
The cellular and molecular mechanisms underpinning childhood absence epilepsy: An investigation of dysfunctional inhibitory microcircuits and the role of SOM+ inhibitory interneurons
Childhood absence epilepsy (CAE) is a generalised, non-convulsive subtype of epilepsy, accounting for 10-17% of all childhood epilepsies. Absence seizures are characterised by a brief loss of consciousness accompanied by ... -
Labour groups and railway construction in Otago, 1869-1873
This long essay is concerned with identifying labour groups involved in railway construction in Otago between the years 1869- 1873. Once identified the object is to see whether any of these groups fit a "railway navvy" ... -
'Odd men from the Pacific' : the participation of Pacific Island men in the 28 (Maori) Battalion in the Second World War
The Maori Battalion's wartime experience forms an important part of the New Zealand and Pacific Island heritage. This study explores the participation of Pacific Islanders in the 28 (Maori) Battalion during World War II. ... -
High Altitude Medicine: Understanding the Mechanism of Acute Mountain Sickness
The present study was undertaken to determine the integrative physiology behind acute mountain sickness (AMS) susceptibility. We compared the respiratory, cardiovascular, renal and cerebrovascular responses to acute ... -
Spirituality, Healthcare and Medical Education: Views from New Zealand Medical Students
Background: Spiritual care is becoming increasingly recognised as important for achieving better health outcomes as identified by patients, families of patients and healthcare professionals. However, spiritual care is not ... -
‘Knowing Me, Knowing You’: Patients’ Perspectives on Doctors Disclosing Personal Illness
There are currently no formal clinical guidelines informing doctors as to whether it is appropriate to disclose their own illness information to patients. The topic of doctor self-illness disclosure (DSID) remains ... -
Does a novel genetic variant, highly expressed in Samoans, explain their increased propensity to develop Chronic Kidney Disease? A pilot study.
Chronic Kidney Disease (CKD) continues to increase globally. In a New Zealand, a community based prevalence study, Pacific peoples had a 2.56 fold higher risk of CKD, controlling for diabetes. Likewise Pacific people ... -
Effects of high intensity interval training vs moderate intensity continuous training on fitness and body composition in active breast cancer survivors
Background: Breast cancer and its treatment are associated with worsened body composition and cardiorespiratory fitness (CRF) in breast cancer survivors. These negative effects can increase overall, cardiovascular and ... -
A history of the Ellison whanau of Otakou
The Ellisons are a leading Ngai Tahu whanau. In this dissertation I use the Ellisons to interpret and examine the Ngai Tahu experience of cross-cultural encounter from the 1830s until the early twentieth century. Specifically, ... -
HPV 16 E6/E7 expressing microparticles alter functional phenotype of Langerhans cell-like cells
High-risk human papillomavirus (HPV) infections can lead to the development of cervical cancer, the fourth most common cancer in women worldwide. High-risk HPV type 16 (HPV16) is responsible for over 50% of cervical cancers ... -
Geology of Takitimu group rocks in the Nugget Hill region, western Southland, New Zealand
An area approximately 31 km2, centered around Nugget Hill in western Southland was mapped in detail. The geology in this area is dominated by Takitimu Group lithologies which are intruded by the White Hill Intrusive Suite. ... -
The role of exocyst members sec6 and sec8 in the anterograde trafficking of KCa3.1 to the basolateral membrane of polarised epithelial cells
In epithelia, ion channels play an essential role in maintaining the required electrochemical gradients for the tissue to function. This function can translate to electrolyte and fluid homeostasis which in turn, relies on ... -
BCG impact on Innate Lymphoid Cells: Determining the Site of Proliferation
Tuberculosis (TB) is an infectious lung disease that is a major cause of mortality, causing an estimated 1.7 million deaths globally per year. The current prophylactic vaccine used against TB, bacille Calmette Guérin (BCG), ... -
The role of Numb in honeybee ovary activation
Environmental signals in utero are throught to induce plastic changes to metabolism and gene regulation, causing diseases such as Type 2 Diabetes. For example, fetal undernutrition is associated with obesity, hyperglycemia, ... -
The role of the mTOR-Raptor complex in driving hyperuricemia-induced diabetes mellitus
Elevated serum uric acid (hyperuricemia) when left untreated can lead to a range of pathologies including gout, cancer and type 2 diabetes mellitus (T2DM). It has been shown that after three days of exposure to hyperuricemic ... -
Disarming tissue factor: generating a model tumour antigen
Coagulative abnormalities are a well-recognised feature of malignancy. The risk of developing thrombotic disorders is increased four-fold in cancer patients and more than six-fold higher in those receiving chemotherapy. ... -
Investigating Teixobactin Tolerance in Enterococcus faecalis
The rapid rise of antimicrobial resistance (AMR) poses a global threat to human health. Key to combating antimicrobial resistance will be to increase our understanding of how resistance develops. Conventional antimicrobial ... -
The presence of ∆133p53 and ∆40p53 in metastatic brain tumours: evidence for further enquiries
Metastatic brain tumours are becoming more prevalent as individuals with primary cancers receive improved treatment and live longer. These brain tumours are difficult to treat and are often left undiagnosed. This study ...