Browsing Thesis - Honours by Date Published
Now showing items 1-20 of 303
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Expression of O-linked N-acetylglucosamine in the Rat Brain during Pregnancy and Lactation
During pregnancy, adaptations occur in the maternal brain and body to ensure optimal nutrition for both the mother and fetus. Over nutrition in the mother can lead to gestational diabetes mellitus (GDM). GDM in mothers is ... -
The role of exocyst members sec6 and sec8 in the anterograde trafficking of KCa3.1 to the basolateral membrane of polarised epithelial cells
In epithelia, ion channels play an essential role in maintaining the required electrochemical gradients for the tissue to function. This function can translate to electrolyte and fluid homeostasis which in turn, relies on ... -
HPV 16 E6/E7 expressing microparticles alter functional phenotype of Langerhans cell-like cells
High-risk human papillomavirus (HPV) infections can lead to the development of cervical cancer, the fourth most common cancer in women worldwide. High-risk HPV type 16 (HPV16) is responsible for over 50% of cervical cancers ... -
Effects of high intensity interval training vs moderate intensity continuous training on fitness and body composition in active breast cancer survivors
Background: Breast cancer and its treatment are associated with worsened body composition and cardiorespiratory fitness (CRF) in breast cancer survivors. These negative effects can increase overall, cardiovascular and ... -
Does a novel genetic variant, highly expressed in Samoans, explain their increased propensity to develop Chronic Kidney Disease? A pilot study.
Chronic Kidney Disease (CKD) continues to increase globally. In a New Zealand, a community based prevalence study, Pacific peoples had a 2.56 fold higher risk of CKD, controlling for diabetes. Likewise Pacific people ... -
‘Knowing Me, Knowing You’: Patients’ Perspectives on Doctors Disclosing Personal Illness
There are currently no formal clinical guidelines informing doctors as to whether it is appropriate to disclose their own illness information to patients. The topic of doctor self-illness disclosure (DSID) remains ... -
Spirituality, Healthcare and Medical Education: Views from New Zealand Medical Students
Background: Spiritual care is becoming increasingly recognised as important for achieving better health outcomes as identified by patients, families of patients and healthcare professionals. However, spiritual care is not ... -
High Altitude Medicine: Understanding the Mechanism of Acute Mountain Sickness
The present study was undertaken to determine the integrative physiology behind acute mountain sickness (AMS) susceptibility. We compared the respiratory, cardiovascular, renal and cerebrovascular responses to acute ... -
The cellular and molecular mechanisms underpinning childhood absence epilepsy: An investigation of dysfunctional inhibitory microcircuits and the role of SOM+ inhibitory interneurons
Childhood absence epilepsy (CAE) is a generalised, non-convulsive subtype of epilepsy, accounting for 10-17% of all childhood epilepsies. Absence seizures are characterised by a brief loss of consciousness accompanied by ... -
Rational Reflection and An Integrative Account of Moral Cognition
This thesis is about the relationship between the brain and morality. In the last two decades there has been a rapid growth in the neuroscience and psychology of morality, such that a new a field has emerged called “moral ... -
Advanced Meta-Analysis and Bariatric Surgery
Background: Obesity is one the most important public health concerns worldwide. Randomised clinical trials (RCT) have compared the various bariatric techniques and these have been incorporated in several meta-analyses and ... -
What does it mean to be a Māori doctor? Historical and contemporary perspectives.
Background: Māori are under-represented in the medical workforce; however, numbers of Māori medical doctors are beginning to grow. This research explores what it means to be a Māori doctor utilising Kaupapa Māori methodology. ... -
Investigation into the relative location of filamin B and YB-1 in cell cycle progression
The cell cycle is a fundamental process in development and the maintenance of homeostasis. Various proteins regulate the cell cycle, such as Y-box binding protein -1 (YB-1). YB-1 transcriptionally regulates cell cycle ... -
Peroxiredoxins as biomarkers of oxidative stress in metastatic melanoma cells
Melanoma is one of the most common forms of skin cancer, and is particularly prevalent in New Zealand and Australia. If detected early, surgery may be curative; however, once metastatic there are very few effective treatments ... -
Gene Modification of Breast Cancer Cells for Cancer Imaging
Human epidermal growth factor receptor 2 (HER2) is a prominent breast cancer cell surface receptor that is overexpressed in approximately 20-30% of breast cancer tumours. Trastuzumab (Herceptin) is an effective clinical ... -
Characterising the Functional and Molecular Determinants for Organ Selective Metastasis in Triple Negative Breast Cancer
Triple-negative breast cancer (TNBC) accounts for 10-20% of primary invasive breast cancer diagnoses, globally. With a higher risk of developing visceral and brain metastasis than other breast cancer subtypes, and limited ... -
TP53 in renal vasculitis
Overview: Vasculitis is an autoimmune disease characterised by the swelling and inflammation of blood vessels. Renal vasculitis is a rare, yet severe disease characterised by the inflammation of glomeruli and affiliated ... -
Bacterial regulation of early activation of mucosal-associated invariant T (MAIT) cells
Mucosal-associated invariant T (MAIT) cells are a population of CD8+ innate-like T cells that play an important role in the immune response to bacterial infections. Being characterised by the expression of a unique ... -
Validation and Characterisation of Novel miRNAs Identified in the E15.5 Mouse Brain
MicroRNAs (miRNAs) are small noncoding elements that downregulate gene expression and play an important role in maintaining robust neurodevelopment. Since abnormal expression of miRNAs has been associated with disorders ... -
Validation and Characterisation of Novel miRNAs Identified in the E15.5 Mouse Brain
MicroRNAs (miRNAs) are small noncoding elements that downregulate gene expression and play an important role in maintaining robust neurodevelopment. Since abnormal expression of miRNAs has been associated with disorders ...