Browsing Thesis - Honours by Date Published
Now showing items 1-20 of 345
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Genetics of Digitocutaneous Dysplasia
The development of the human skeleton is a precisely controlled process. The study of Mendelian diseases involving abnormalities in the skeleton enables the idenfication of factors critical to skeletal development. Digi ... -
Role of CaMKII and Alpha Stimulation in Heart Function
Cardiovascular disease is a major cause of morbidity and mortality in New Zealand. Elucidating its pathogenesis will help us better treat those who are affected by it. One protein that has been implicated in cardiovascular ... -
Constructive Arrows: An Introduction to Categories, Toposes and Logic
Category theory, especially topos theory, admits a new perspective on the study of logic and mathematical foundations. In this dissertation, we provide an introduction to the development of logic in a topos, and show why ... -
E Tū Kahikatea: An Evaluation of the Tū Kahika Foundation Year Scholarship at the University of Otago
The purpose of this thesis is to evaluate the Tū Kahika Foundation Year Scholarship at the University of Otago. The Tū Kahika Foundation Year Scholarship is a recruitment intervention that assists Māori secondary school ... -
The Application of Circulating Tumour DNA to the Management of Gastrointestinal Cancers.
Circulating tumour DNA (ctDNA) are small fragments of DNA released by tumours into the circulation. These fragments contain pathogenic mutations which can be detected and quantified by various next generation sequencing ... -
Expression of O-linked N-acetylglucosamine in the Rat Brain during Pregnancy and Lactation
During pregnancy, adaptations occur in the maternal brain and body to ensure optimal nutrition for both the mother and fetus. Over nutrition in the mother can lead to gestational diabetes mellitus (GDM). GDM in mothers is ... -
Investigating the Influence of Metabolic Syndrome on Cancer Immunotherapy
Cancer is a significant cause of morbidity in New Zealand, with breast and colorectal cancers being amongst the most commonly diagnosed. Therapeutic research has moved into immunotherapies, harnessing the immune system to ... -
In situ expression of biomarkers in placenta in the context of hypertensive disorders of pregnancy
Overview: Hypertensive disorders in pregnancy (HDP), of which the most common is pre- eclampsia (PE), are a leading cause of maternal and foetal morbidity and mortality worldwide. Despite extensive research, no clear cause ... -
Investigating the Direct Role of Promoter DNA Methylation in Gene Expression using a Targeted TET1CD-dCas9 Demethylase Tool
DNA hypermethylation of gene promoter regions has long been associated with transcriptional repression. Furthermore, the establishment of dense promoter methylation within tumour- suppressor genes has been widely-characterised ... -
Cranberry capsules for acute radiation induced cystitis: The Kathleen Kilgour Centre experience
Acute cystitis is a common radiation side effect in prostate cancer patients undergoing radiation therapy treatment which results from radiation damage to the bladder. Acute cystitis symptoms can occur within weeks of ... -
Adolescent autonomy in medical decision making
Normally in the health profession there is a requirement to gain valid consent from patients before treatment can be given. This respect for patient autonomy has become a cornerstone of modern medical practice, however not ... -
The role of gene duplication and neofunctionalization in the sexual plasticity of teleost fish
Sex determination and differentiation varies widely across vertebrates. In teleost fish these processes are remarkably plastic. In contrast to a gonochoristic system where the sexes are separate, fish that begin life as ... -
Epicardial adipose tissue morphology diversity in Māori, Pacific and New Zealand/European post mortem cases
Obesity is a global epidemic, and is the leading risk factor for heart disease and associated morbidities in New Zealand. Furthermore, Māori and Pacific New Zealand populations are up to 8 times more likely to develop ... -
The effect of combination drug inhibition of ALK and Src on cell growth in ALK-positive non-small cell lung cancer
Lung cancer is the leading cause of cancer mortality worldwide, accounting for approximately 1.6 million deaths per annum. The most common form of lung cancer is non-small cell lung cancer, and within this, ALK mutations ... -
Characterising TRIB1 Nanobodies using a Yeast Surface Display Platform with Flow Cytometry
The mammalian tribble (TRIB) pseudokinase family has three homologues, which act as an adaptor protein to regulate cell signalling pathways. TRIB proteins can bind the E3 ligase, Constitutive Photomorphogenesis Protein 1 ... -
The interaction of neutrophils and amyloid-ß in Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that affects memory and cognition. A key molecular pathological hallmark of AD is amyloid-ß deposition. Amyloid-ß is a small aggregation-prone peptide ... -
Regulation of cardiac ryanodine receptor 2 by protein kinase CK2
The cardiac muscle ryanodine receptor (RyR2) is an intracellular Ca2+ channel responsible for the release of Ca2+ during excitation-contraction coupling. It is also implicated in pathological store-overload-induced Ca2+ ... -
Assessing the translational potential of oxytocin receptor blockade as a novel therapy for cardiac sympathetic activation following acute myocardial infarction
Abnormal elevation of cardiac sympathetic nerve activity (cSNA) is a major contributor to the high mortality rate associated with acute myocardial infarction (MI). Increase in cSNA results in the propagation of ventricular ... -
Structural and functional characterisation of glutamate racemase isoform 2 from Acinetobacter baumannii
Acinetobacter baumannii is an opportunistic pathogen associated with high patient mortality within the Intensive Care Unit. The spread of antimicrobial resistance has resulted in some strains carrying up to 45 resistance ... -
Investigating the activation of nucleus accumbens projective paraventricular nucleus of the thalamus during cue-food reward conditioning
When a previously neutral cue is learnt to predict a food reward, the presence of the cue itself can elicit the motivation to obtain the food. The nucleus accumbens shell (nAccSh) in the mesolimbic system is involved in ...