Browsing Thesis - Honours by Date Published
Now showing items 1-20 of 298
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The role of exocyst members sec6 and sec8 in the anterograde trafficking of KCa3.1 to the basolateral membrane of polarised epithelial cells
In epithelia, ion channels play an essential role in maintaining the required electrochemical gradients for the tissue to function. This function can translate to electrolyte and fluid homeostasis which in turn, relies on ... -
HPV 16 E6/E7 expressing microparticles alter functional phenotype of Langerhans cell-like cells
High-risk human papillomavirus (HPV) infections can lead to the development of cervical cancer, the fourth most common cancer in women worldwide. High-risk HPV type 16 (HPV16) is responsible for over 50% of cervical cancers ... -
Effects of high intensity interval training vs moderate intensity continuous training on fitness and body composition in active breast cancer survivors
Background: Breast cancer and its treatment are associated with worsened body composition and cardiorespiratory fitness (CRF) in breast cancer survivors. These negative effects can increase overall, cardiovascular and ... -
Does a novel genetic variant, highly expressed in Samoans, explain their increased propensity to develop Chronic Kidney Disease? A pilot study.
Chronic Kidney Disease (CKD) continues to increase globally. In a New Zealand, a community based prevalence study, Pacific peoples had a 2.56 fold higher risk of CKD, controlling for diabetes. Likewise Pacific people ... -
‘Knowing Me, Knowing You’: Patients’ Perspectives on Doctors Disclosing Personal Illness
There are currently no formal clinical guidelines informing doctors as to whether it is appropriate to disclose their own illness information to patients. The topic of doctor self-illness disclosure (DSID) remains ... -
Spirituality, Healthcare and Medical Education: Views from New Zealand Medical Students
Background: Spiritual care is becoming increasingly recognised as important for achieving better health outcomes as identified by patients, families of patients and healthcare professionals. However, spiritual care is not ... -
High Altitude Medicine: Understanding the Mechanism of Acute Mountain Sickness
The present study was undertaken to determine the integrative physiology behind acute mountain sickness (AMS) susceptibility. We compared the respiratory, cardiovascular, renal and cerebrovascular responses to acute ... -
The cellular and molecular mechanisms underpinning childhood absence epilepsy: An investigation of dysfunctional inhibitory microcircuits and the role of SOM+ inhibitory interneurons
Childhood absence epilepsy (CAE) is a generalised, non-convulsive subtype of epilepsy, accounting for 10-17% of all childhood epilepsies. Absence seizures are characterised by a brief loss of consciousness accompanied by ... -
Rational Reflection and An Integrative Account of Moral Cognition
This thesis is about the relationship between the brain and morality. In the last two decades there has been a rapid growth in the neuroscience and psychology of morality, such that a new a field has emerged called “moral ... -
Advanced Meta-Analysis and Bariatric Surgery
Background: Obesity is one the most important public health concerns worldwide. Randomised clinical trials (RCT) have compared the various bariatric techniques and these have been incorporated in several meta-analyses and ... -
What does it mean to be a Māori doctor? Historical and contemporary perspectives.
Background: Māori are under-represented in the medical workforce; however, numbers of Māori medical doctors are beginning to grow. This research explores what it means to be a Māori doctor utilising Kaupapa Māori methodology. ... -
The Expression of a p53 Isoform Δ133p53, in the Cell Cycle
Overview: p53 is a principal tumour suppressor protein that regulates the cell cycle. By doing so, p53 prevents damaged cells from undergoing DNA replication and cell division by activating pathways involved in DNA repair, ... -
TP53 in renal vasculitis
Overview: Vasculitis is an autoimmune disease characterised by the swelling and inflammation of blood vessels. Renal vasculitis is a rare, yet severe disease characterised by the inflammation of glomeruli and affiliated ... -
Regulation of Antigen Presenting Cells by Human Papillomavirus Small Extracellular Vesicles
Human Papillomavirus (HPV) causes over 99% of cervical cancer cases in the world, and of these, over 70% of cases can be attributed to high-risk HPV. There are prophylactic vaccines for HPV, that specifically target high-risk ... -
Mycobacterial resistance to neutrophil oxidants
Neutrophils are one of the first immune cells to respond when lungs are infected with Mycobacterium tuberculosis – the world’s leading infectious killer that results in millions of deaths every year. Normally, neutrophils ... -
Investigating the mechanisms driving circadian and sex differences in the stress axis
The stress response allows the body to adapt to an ever-changing environment. Stress results in the activation of corticotrophin releasing hormone (CRH) neurons in the paraventricular nucleus (PVN) of the hypothalamus. ... -
Generation of FMC63 scFv specific anti-idiotype antibodies for quality control of anti-CD19 CAR T cell trials
Chimeric antigen receptor (CAR) T cell therapy is an emerging form of immunotherapy that has revolutionised the treatment of some cancers. This is especially true for relapsed and refractory (r/r) lymphoma where it has ... -
uORF-mediated translational regulation of drought stress response gene MASP1 in Arabidopsis thaliana
Human-induced climate variability can subject global regions to water scarcity, prompting widespread crop failure. This calls for innovations that preserve global food security that do not further contribute to climate ... -
Validation and Characterisation of Novel miRNAs Identified in the E15.5 Mouse Brain
MicroRNAs (miRNAs) are small noncoding elements that downregulate gene expression and play an important role in maintaining robust neurodevelopment. Since abnormal expression of miRNAs has been associated with disorders ... -
Effect of WNT/β-catenin Signalling on T cells in Colorectal Cancer
Worldwide, colorectal cancer (CRC) is the fourth most common cancer and has the second highest mortality rate of any cancer. Only a subset of CRC patients respond to immunotherapies. This lack of response may be due to the ...