Browsing Thesis - Honours by Date Published
Now showing items 1-20 of 308
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Expression of O-linked N-acetylglucosamine in the Rat Brain during Pregnancy and Lactation
During pregnancy, adaptations occur in the maternal brain and body to ensure optimal nutrition for both the mother and fetus. Over nutrition in the mother can lead to gestational diabetes mellitus (GDM). GDM in mothers is ... -
Regulation of cardiac ryanodine receptor 2 by protein kinase CK2
The cardiac muscle ryanodine receptor (RyR2) is an intracellular Ca2+ channel responsible for the release of Ca2+ during excitation-contraction coupling. It is also implicated in pathological store-overload-induced Ca2+ ... -
Investigating the Influence of Metabolic Syndrome on Cancer Immunotherapy
Cancer is a significant cause of morbidity in New Zealand, with breast and colorectal cancers being amongst the most commonly diagnosed. Therapeutic research has moved into immunotherapies, harnessing the immune system to ... -
Structural and functional characterisation of glutamate racemase isoform 2 from Acinetobacter baumannii
Acinetobacter baumannii is an opportunistic pathogen associated with high patient mortality within the Intensive Care Unit. The spread of antimicrobial resistance has resulted in some strains carrying up to 45 resistance ... -
In situ expression of biomarkers in placenta in the context of hypertensive disorders of pregnancy
Overview: Hypertensive disorders in pregnancy (HDP), of which the most common is pre- eclampsia (PE), are a leading cause of maternal and foetal morbidity and mortality worldwide. Despite extensive research, no clear cause ... -
Investigating the Direct Role of Promoter DNA Methylation in Gene Expression using a Targeted TET1CD-dCas9 Demethylase Tool
DNA hypermethylation of gene promoter regions has long been associated with transcriptional repression. Furthermore, the establishment of dense promoter methylation within tumour- suppressor genes has been widely-characterised ... -
‘Knowing Me, Knowing You’: Patients’ Perspectives on Doctors Disclosing Personal Illness
There are currently no formal clinical guidelines informing doctors as to whether it is appropriate to disclose their own illness information to patients. The topic of doctor self-illness disclosure (DSID) remains ... -
Spirituality, Healthcare and Medical Education: Views from New Zealand Medical Students
Background: Spiritual care is becoming increasingly recognised as important for achieving better health outcomes as identified by patients, families of patients and healthcare professionals. However, spiritual care is not ... -
The role of exocyst members sec6 and sec8 in the anterograde trafficking of KCa3.1 to the basolateral membrane of polarised epithelial cells
In epithelia, ion channels play an essential role in maintaining the required electrochemical gradients for the tissue to function. This function can translate to electrolyte and fluid homeostasis which in turn, relies on ... -
High Altitude Medicine: Understanding the Mechanism of Acute Mountain Sickness
The present study was undertaken to determine the integrative physiology behind acute mountain sickness (AMS) susceptibility. We compared the respiratory, cardiovascular, renal and cerebrovascular responses to acute ... -
Effects of high intensity interval training vs moderate intensity continuous training on fitness and body composition in active breast cancer survivors
Background: Breast cancer and its treatment are associated with worsened body composition and cardiorespiratory fitness (CRF) in breast cancer survivors. These negative effects can increase overall, cardiovascular and ... -
Does a novel genetic variant, highly expressed in Samoans, explain their increased propensity to develop Chronic Kidney Disease? A pilot study.
Chronic Kidney Disease (CKD) continues to increase globally. In a New Zealand, a community based prevalence study, Pacific peoples had a 2.56 fold higher risk of CKD, controlling for diabetes. Likewise Pacific people ... -
Advanced Meta-Analysis and Bariatric Surgery
Background: Obesity is one the most important public health concerns worldwide. Randomised clinical trials (RCT) have compared the various bariatric techniques and these have been incorporated in several meta-analyses and ... -
Generation of FMC63 scFv specific anti-idiotype antibodies for quality control of anti-CD19 CAR T cell trials
Chimeric antigen receptor (CAR) T cell therapy is an emerging form of immunotherapy that has revolutionised the treatment of some cancers. This is especially true for relapsed and refractory (r/r) lymphoma where it has ... -
uORF-mediated translational regulation of drought stress response gene MASP1 in Arabidopsis thaliana
Human-induced climate variability can subject global regions to water scarcity, prompting widespread crop failure. This calls for innovations that preserve global food security that do not further contribute to climate ... -
Regulation of Antigen Presenting Cells by Human Papillomavirus Small Extracellular Vesicles
Human Papillomavirus (HPV) causes over 99% of cervical cancer cases in the world, and of these, over 70% of cases can be attributed to high-risk HPV. There are prophylactic vaccines for HPV, that specifically target high-risk ... -
Validation and Characterisation of Novel miRNAs Identified in the E15.5 Mouse Brain
MicroRNAs (miRNAs) are small noncoding elements that downregulate gene expression and play an important role in maintaining robust neurodevelopment. Since abnormal expression of miRNAs has been associated with disorders ... -
Effect of WNT/β-catenin Signalling on T cells in Colorectal Cancer
Worldwide, colorectal cancer (CRC) is the fourth most common cancer and has the second highest mortality rate of any cancer. Only a subset of CRC patients respond to immunotherapies. This lack of response may be due to the ... -
Investigation into the relative location of filamin B and YB-1 in cell cycle progression
The cell cycle is a fundamental process in development and the maintenance of homeostasis. Various proteins regulate the cell cycle, such as Y-box binding protein -1 (YB-1). YB-1 transcriptionally regulates cell cycle ... -
ADSC-EVs and Macrophage Polarization in Fat Grafting for Breast Reconstruction
Breast Cancer is the most commonly diagnosed cancer among women in New Zealand, with an estimated 3000 women diagnosed in New Zealand every year. The most common form of treatment is surgery, and following treatment, the ...