Browsing Thesis - Honours by Date Published
Now showing items 1-20 of 226
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Dementia and Identity
This thesis explores the multiple ways identity can be affected by dementia. It primarily concerns how ‘personal identity’ is affected in the early to moderate stages of dementia, and secondarily concerns how ‘personhood’ ... -
Adrenergic stimulation of HK-2 proximal tubular cells in hyperglycaemic conditions
One of the most commonly associated complications of Diabetes Mellitus is nephropathy, with one in five diabetics sustaining renal injury over their lives. Renal denervation has been shown to decrease systemic blood pressure ... -
The Global Health Classroom: Collaborative Global Health Learning between New Zealand and Samoan Medical Students in a Virtual Classroom
Background Global Health is recognised as an essential component of undergraduate medical curricula to equip future doctors with the relevant knowledge, attitudes, and skills to practice in a globalised world. The Global ... -
The Epigenetics of Coronary Artery Disease: A Study of DNA Methylation
Coronary artery disease (CAD) is a complex condition, the development of which involves interaction between both genetic and environmental factors. Epigenetic mechanisms, including DNA methylation, may contribute significantly ... -
Healthy & Climate-friendly Eating Patterns for New Zealand
Under the 2015 Paris Climate Agreement, New Zealand (NZ) committed to reducing greenhouse gas emissions (GHGs): all major government policies should, therefore, consider impacts on the climate. Given that the Ministry of ... -
Pacific youth views on health and wellbeing: a photovoice study
Preliminary findings from an ongoing study partnership between the Pacific Trust Otago and the University of Otago have reported an association between measures of wellbeing, mental health and markers of metabolic ill-health ... -
Vision screening in the Southern and Tairawhiti DHBs: An audit of the B4 School Check
Amblyopia, or ‘lazy eye’, describes visual impairment occurring due to abnormal cortico-visual development as a child, and is the most common ophthalmological condition in children. The critical period for visual development ... -
Investigating the role of peroxiredoxin in hydrogen peroxide signalling
Hydrogen peroxide (H2O2) was viewed as an unwanted by-product of aerobic respiration for many years but it is now well-established as being involved in many different signalling pathways. H2O2 is reduced to water by ... -
Predictors of Referral Delay and Treatment Response to Intravitreal Bevacizumab for Wet Age-Related Macular Degeneration
Background: Recent years have seen anti-vascular endothelial growth factor (VEGF) agents revolutionize the treatment of wet age-related macular degeneration (AMD). To ensure optimal outcomes for this time-sensitive ... -
The proportion of fast and slow neuromuscular junctions in young and old mice
Human skeletal mass and strength increase from birth until ~35 years of age, thereafter a decline in mass and strength occurs in a process called sarcopenia. Beyond 60 years of age muscular weakness falls to a point where ... -
Modulation of DNA methylation by L-ascorbate and 5-aza-2’-deoxycytidine in murine embryonic stem cells
Cytosine methylation, normally found on cytosine residues adjacent to guanine (i.e., a CpG dinucleotide), is one means by which long-term gene repression occurs. Immediately after semi-conservative DNA replication, CpG ... -
The Cytotoxicity and Action of Curcumin Derivatives against Fn14+ Triple Negative Breast Cancer through repression of NF-κB p65
Triple negative breast cancer (TNBC) is an aggressive subtype of the disease which lacks options for targeted systemic therapies due to a lack of actionable clinical targets. Molecular analysis has revealed that Fn14, a ... -
Influence of the p53 isoform, delta133p53, on cytoskeletal dynamics during the initiation of migration
The well-known tumour suppressor p53 is known to prevent the development of tumours. Recent research has highlighted the importance of an N-truncated isoform, Δ133p53, in the progression of metastatic cancers. This particular ... -
Lhx9 is required for urogenital ridge development and ovarian function
While there has been extensive research into the differentiation of sexually dimorphic gonads, there is much to learn about the bi-potential structure they arise from, the urogenital ridge (UGR). This gap in knowledge is ... -
Investigating the Site of Innate Lymphoid Cell Division Following BCG Vaccination
Tuberculosis (TB) is the most deadly infectious disease worldwide, killing 1.4 million people each year. Efforts to control the spread of this disease through antibiotic treatments and a century-old preventative vaccine, ... -
Identification of Transporters Involved in Drug-drug Interactions During Gout Treatment in Primary Rat Hepatocytes
Gout is one of the most common form of inflammatory arthritis, with hyperuricemia as the major risk factor. Chronic hyperuricemia, or high level of serum uric acid (SUA), can lead to the formation of monosodium urate ... -
The effect of the trafficking protein p11 on the epithelial sodium channel
Regulation of renal sodium (Na+) excretion is crucial for the maintenance of extracellular salt and volume homeostasis and thus for blood pressure control. The epithelial sodium channel (ENaC) is composed of three subunits; ... -
Predisposition to Non Alcoholic Fatty Liver Disease in Preterm Guinea Pigs
Background: Preterm birth accounts for ~10% of all births and is now an established risk factor for the development of metabolic syndrome, a cluster of conditions responsible for significant morbidity and mortality in New ... -
PKCε Phosphorylation of RyR2: A Novel Link between Diabetes and Arrhythmia.
Cardiovascular disease (CVD) is the leading cause of death in the world. Arrhythmia is a type of CVD which can be caused by store overload induced calcium (Ca2+) release (SOICR) in cardiomyocytes. SOICR occurs ... -
Measuring Markers of Immune Response in Patients Treated with Nivolumab (Opdivo®) and Pembrolizumab (Keytruda®)
Immune checkpoint inhibitors (ICIs) have drastically improved the clinical outcome for many cancer patients. However, not all patients treated with ICIs show a clinical response and the development of a unique spectrum of ...