Browsing Thesis - Honours by Title
Now showing items 1-20 of 222
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11 week Beta-Hydroxy beta-Methylbutyric acid (HMB) supplementation: Effects on body composition and exercise performance in trained athletes.
Background: Originally used in the farming industry to ‘bulk up’ cattle, interest in the leucine metabolite, beta-hydroxy beta-methylbutyrate (HMB), has been growing following a clinical trial which demonstrated significant ... -
17α-hydroxylase and the androgen-treated sheep ovary – a model for Polycystic Ovary Syndrome (PCOS)
Polycystic Ovary Syndrome (PCOS) is the most common cause of infertility in women of reproductive age, with an estimated five to ten percent of women worldwide affected by the endocrine condition. The aetiology of PCOS ... -
24 – hour oxygen saturation recordings at discharge in preterm infants
Preterm infants have an immature respiratory system and therefore experience an increased number of respiratory pauses and oxygen desaturations. There is now advanced pulse oximetry technology that can record oxygen ... -
A new target for treating arrhythmia? Interaction of triadin with the cardiac ryanodine receptor reduces Store Overload Induced Calcium Release
Arrhythmia occurs in a number of heart diseases including heart failure (HF) and Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT). It has been shown that Store Overload Induced Calcium Release (SOICR) is a ... -
A novel genetically encoded voltage indicator for studying motor cortical circuitry
The primary motor cortex (M1) consists of layers that are occupied by distinctive excitatory pyramidal neuron and inhibitory interneuron populations. Neurons within each layer receive inputs from numerous cortical and ... -
A novel strategy to prevent bacterial biofilm formation using methylthioadenosine-nucleosidase inhibitors
Each year there are approximately 2.9 million joint replacement surgeries performed worldwide. Great efforts have been made to reduce infection rates in these replacements in the past and yet these rates have not decreased ... -
A novel technique to investigate coronary microvascular perfusion in diabetes
Diabetes Mellitus (DM)-induced disease of the coronary microvessels contributes to the worldwide increase in cardiovascular morbidity and mortality in diabetic patients. These microvessels are vital to the regulation of ... -
A role for alpha-7 nAChRs at cerebellar synapses
The cerebellum performs a well-known motor control function but accumulating evidence supports its role in cognitive functions. The nicotinic cholinergic system alters cognition through its actions elsewhere in the brain ... -
A search for synthetic lethality between Polo-like Kinase 3 and E- Cadherin
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant condition caused by a mutation in the tumour suppressor gene E-cadherin, (CDH1). It predisposes to a 70% likelihood of developing highly penetrant diffuse ... -
A Survey of Māori Medical Graduates from Te Whare Wānanga o Otāgo
INTRODUCTION Māori health workforce development is an important part of the strategy for improving Māori health and reducing inequalities and Māori doctors are an important part of this workforce. This research aimed to ... -
A tale of two fates: the role of histone modifications in establishing bipotentiality
Sex determination and differentiation is an essential process all mammals must undergo to reproduce. This process in mammals is initiated through the development of a bipotential tissue, the urogenital ridge (UGR), which ... -
A Validation Study to Detect Markers of Proliferation Adequacy in the Endometrium
Throughout the human female menstrual cycle, the endometrial lining of the uterus transitions from a non-receptive proliferative state to a receptive secretory state. This transition is required to prepare the endometrium ... -
Abduction Strength Deficiency: How Common, How Early and How Amendable?
Gluteus medius strength deficiency has been linked to various injuries of the lower limb (Fairclough et al., 2007, Bullock-Saxton et al., 1993, Powers et al., 2003, Williams and Cohen, 2009). However there is limited ... -
Access to elective and acute orthopaedic surgery in Dunedin: an analysis of surgical delay
Background: Delay in surgical intervention may lead to significant personal, medical and economical consequences. For individuals undergoing treatment in the public health system, there is inevitably a delay in access to ... -
Adrenergic stimulation of HK-2 proximal tubular cells in hyperglycaemic conditions
One of the most commonly associated complications of Diabetes Mellitus is nephropathy, with one in five diabetics sustaining renal injury over their lives. Renal denervation has been shown to decrease systemic blood pressure ... -
Ageing Astrocytes - Implications for Motoneuron Dysfunction and Sarcopenia
Sarcopenia: The most conspicuous intractable feature of advancing age is the gradual loss of skeletal muscle mass and the resultant loss of strength and mobility, and this is a major driver of morbidity and mortality in ... -
Allocation and Ageism in Aotearoa: An exploration of the ethical justification for age-based healthcare rationing
New Zealand’s population, like many first world countries, is ‘ageing’. This will place our healthcare system under increasing and changing pressures, as there will be a greater proportion of older people in our population ... -
An in vivo investigation into the morphology of whole GnRH neurons
The ability to pass on genetic information through reproduction represents nature’s basic element of existence. Central to the control of reproduction is gonadotropin-releasing hormone (GnRH), a neuropeptide synthesized ... -
An investigation of the correlations between subjective and objective measures of bowel inflammation in Spondyloarthritis
Introduction: Spondyloarthritis (SpA) and Inflammatory Bowel Disease (IBD) are related conditions of unknown aetiology demonstrating both common clinical features and common genetic and immunological pathomechanisms. ... -
Anatomical Characterisation of Prolactin Receptor Expression in the Developing Mouse Brain
Prolactin signalling through the prolactin receptor plays a significant role in many physiological processes. The diverse biological functions attributed to prolactin are largely dependent on the distribution of its receptor. ...