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Functional Analysis of Disease-Associated 3’ UTR Variants: the CXCL12β 3’ UTR G801A Polymorphism
In recent years, the previously neglected 3’ untranslated region (UTR) has gained recognition as a critical region in the regulation of gene expression. Numerous studies have been conducted on disease-associated 3’ UTR ...
The structure of the mucosal folds within the pancreaticobiliary junction
BACKGROUND: This investigation concerns a structure within the pancreaticoduodenal region of the body, known as the pancreaticobiliary junction (PBJ), which is formed from the convergence of the terminal common bile and ...
The arterial supply of the ulnar nerve and cubital tunnel ischaemia
Background: The ulnar nerve is a major nerve in the upper limb and is susceptible to injury, particularly in the region of the cubital tunnel. A suspected mechanism of injury at this site is ischaemia. Whilst this can be ...
Histamine mediated neuropeptide gene expression in bovine chromaffin cells
The adrenal medulla regulates the acute stress response and is itself controlled through a variety of signals, including neuronal, endocrine and paracrine factors. Additionally, recent literature suggests that adrenal ...
Endogenous Immune Responses to Colorectal Cancer
An ideal immunotherapy for colorectal cancer would target an endogenous tumour antigen. Endogenous antigens produce a more physiologically relevant immune response than model antigens traditionally used to study anti-tumour ...
A novel genetically encoded voltage indicator for studying motor cortical circuitry
The primary motor cortex (M1) consists of layers that are occupied by distinctive excitatory pyramidal neuron and inhibitory interneuron populations. Neurons within each layer receive inputs from numerous cortical and ...
Multiple Dosing of RHDV VLP to Enhance the Anti-tumour Response
Metastatic melanoma has a poor prognosis, with a median survival of 13 months after diagnosis. New Zealand has among the highest melanoma rates in the world with more than 2000 cases registered every year. Metastatic ...
The actions of Activin C and its mechanism towards the progression of Prostate disease
The Transforming Growth Factor β (TGF β) superfamily is involved with regulating many biological and physiological processes. Activins are members of the TGF β superfamily. Four activin subunits (βA, βB, βC and βE) have ...
Inhibiting the pro-inflammatory cytokine MIF
Macrophage migration inhibitory factor (MIF) is a highly conserved regulatory cytokine, known to exert pro-inflammatory effects. MIF biological activity is primarily regulated via interaction with the CD74 receptor. MIF ...
Investigation of a mutation in CYP26B1
Retinoic acid is known to have several important roles in embryonic development, including limb and hindbrain development and has been shown to induce neural tube defects when it is present at teratogenic levels. The CYP26 ...