The development of a positive energy balance occurs during pregnancy to support the growth of fetal and maternal tissues, and to increase energy stores in preparation for the metabolic demands of lactation. Leptin levels ...

Hyperventilation Syndrome (HVS) is a functional breathing disorder characterised by recurrent or chronic changes in breathing pattern causing respiratory and non-respiratory complaints that cannot be attributed to any ...

Objectives This project aims to identify and examine in detail some of the ethically challenging aspects of the care of infants who have serious medical conditions, by looking at a multidisciplinary team (MDT) and whãnau ...

Background The burden of Hepatitis C virus (HCV) is projected to increase substantially over the next 2 decades as a result of complications arising from chronically infected individuals who remain undiagnosed and untreated. ...

Neuronal Ceroid Lipofuscinoses (NCL) are a group of debilitating and fatal neurodegenerative diseases of childhood resulting from progressive brain atrophy. The human and ovine variant late infantile CLN6 (ceroid lipofuscinosis ...

Endogenous hydrogen sulfide (H2S) has recently been described as the third gaseous mediator of interest. It has been proposed in the literature [1] , that H2S has a role in inflammation, through the induction of upstream ...

Macrophage migration inhibitory factor (MIF) is a highly conserved regulatory cytokine, known to exert pro-inflammatory effects. MIF biological activity is primarily regulated via interaction with the CD74 receptor. MIF ...

The Transforming Growth Factor β (TGF β) superfamily is involved with regulating many biological and physiological processes. Activins are members of the TGF β superfamily. Four activin subunits (βA, βB, βC and βE) have ...

Retinoic acid is known to have several important roles in embryonic development, including limb and hindbrain development and has been shown to induce neural tube defects when it is present at teratogenic levels. The CYP26 ...

Release of Ca2+ from the sarcoplasmic reticulum (SR), mediated by the activation of the ryanodine receptor (RyR2), initiates myocardial contraction. This process of Ca2+-induced Ca2+ release is confined within a 20 nm ...