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Characterisation of a phase-variable restriction-modification system in Enterococcus faecalis
The gastrointestinal colonizer Enterococcus faecalis is an opportunistic, multi-drug resistant pathogen and a leading cause of nosocomial infections. Vancomycin- resistant enterococci (VRE) are of particular concern and ...
The role of the mTOR-Raptor complex in driving hyperuricemia-induced diabetes mellitus
Elevated serum uric acid (hyperuricemia) when left untreated can lead to a range of pathologies including gout, cancer and type 2 diabetes mellitus (T2DM). It has been shown that after three days of exposure to hyperuricemic ...
Investigating Teixobactin Tolerance in Enterococcus faecalis
The rapid rise of antimicrobial resistance (AMR) poses a global threat to human health. Key to combating antimicrobial resistance will be to increase our understanding of how resistance develops. Conventional antimicrobial ...
CNVs and familial breast and ovarian cancer
BRCA1 pathogenic variant carriers experience a high risk of developing breast and ovarian cancer, however, differences in risk vary greatly between individuals. The advent of genetic testing has presented an increasing ...
Modulation of DNA methylation by L-ascorbate and 5-aza-2’-deoxycytidine in murine embryonic stem cells
Cytosine methylation, normally found on cytosine residues adjacent to guanine (i.e., a CpG dinucleotide), is one means by which long-term gene repression occurs. Immediately after semi-conservative DNA replication, CpG ...
A novel strategy to prevent bacterial biofilm formation using methylthioadenosine-nucleosidase inhibitors
Each year there are approximately 2.9 million joint replacement surgeries performed worldwide. Great efforts have been made to reduce infection rates in these replacements in the past and yet these rates have not decreased ...
Regulation of cardiac ryanodine receptor 2 by protein kinase CK2
The cardiac muscle ryanodine receptor (RyR2) is an intracellular Ca2+ channel responsible for the release of Ca2+ during excitation-contraction coupling. It is also implicated in pathological store-overload-induced Ca2+ ...
Effects of maternal immune activation on brain arginine metabolism and microglia during neonatal neurodevelopment
Schizophrenia is a debilitating chronic mental disorder with prominent frontal and hippocampal dysfunction. While the exact cause of schizophrenia is poorly understood, a number of factors, including neurodevelopmental ...
The long term consequences of preterm birth in guinea pigs
Background: Preterm birth has long been associated with impaired long term neurodevelopmental and health outcomes in ex-preterm adults and children. However, the precise mechanism linking preterm birth and impaired outcomes ...
Identification of Transporters Involved in Drug-drug Interactions During Gout Treatment in Primary Rat Hepatocytes
Gout is one of the most common form of inflammatory arthritis, with hyperuricemia as the major risk factor. Chronic hyperuricemia, or high level of serum uric acid (SUA), can lead to the formation of monosodium urate ...