Background: Pre-eclampsia (PE) is a hypertensive disorder of pregnancy which is characterised by reduced placental cell invasion into the maternal arteries. Lack of invasion causes insufficient transformation of arteries ...

DNA methylation is an epigenetic modification established during cellular differentiation, and when removed by either active or passive means, can substantially improve the efficiency by which induced pluripotent stem cells ...

Leydig cells (LCs) are found within the interstitium of the testes. LCs are crucial to male reproductive function due to their role in testosterone synthesis, a process vital for both organogenesis and secondary sex ...

Reproductive function is tightly controlled by nutritional state due to its high energetic demands. Regulation of fertility according to available energy stores is attained through the integration of metabolic status signals ...

The cardiac muscle ryanodine receptor (RyR2) is an intracellular Ca2+ channel responsible for the release of Ca2+ during excitation-contraction coupling. It is also implicated in pathological store-overload-induced Ca2+ ...

Acute myeloid leukaemia (AML) is a deadly disease characterised by the abnormal proliferation of immature blood cells in the bone marrow with a block in haematopoietic differentiation. The disease is heterogeneous, and ...

Mucosal-associated invariant T (MAIT) cells are a subset of antibacterial innate-like T cells that are localised to mucosal surfaces. MAIT cells are characterised by the expression of a semi-invariant T cell receptor, ...

Skin and soft tissue infections (SSTIs) affect millions of individuals worldwide, every year. SSTIs vary in complexity and severity, ranging from superficial skin infections such as impetigo to more severe, polymicrobial, ...

Acinetobacter baumannii is an opportunistic pathogen associated with high patient mortality within the Intensive Care Unit. The spread of antimicrobial resistance has resulted in some strains carrying up to 45 resistance ...