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Hydrogen Sulfide: Investigation into the Effects of Different H2S Donors on the Upregulation of Inflammatory Cytokines
Endogenous hydrogen sulfide (H2S) has recently been described as the third gaseous mediator of interest. It has been proposed in the literature [1] , that H2S has a role in inflammation, through the induction of upstream ...
Characterization of Alkyltriphenylphosphonium Cations and Their Interaction with Bacterial Cells
Tuberculosis (TB) is a difficult to treat disease caused by the bacterium Mycobacterium tuberculosis. M. tuberculosis is able to shut down its metabolism in response to diverse environmental cues and enter a stage of ...
Role of the Host Microtubule Cytoskeleton in Infection of Human Cells by Yersinia enterocolitica
The bacterial pathogen Yersinia enterocolitica causes food-borne illnesses resulting in gastroenteritis, metastatic abscesses and sepsis. Yersinia promotes its internalisation into human cells through the binding of the ...
The involvement of mGluR1 hyper-activation in the progression of cerebellar ataxia in SCA1 mice
Spinocerebellar ataxia type 1 (SCA1) is an incurable, autosomal dominant progressive neurodegenerative disorder characterised by ataxia, progressive motor deterioration and selective neuronal loss in the cerebellum. It ...
Exploring the physiological and functional differences between stem cells isolated from the human right atrium and left ventricle
Recent discovery of resident cardiac stem cells (CSCs), capable of cardiac lineage differentiation and paracrine mediated effects, suggest promise for cardiac tissue repair. The best site in the heart for obtaining CSCs ...
Comparing subpopulations of gonadotropin-releasing hormone (GnRH) neurons with viral mediated cell-filling
Gonadotropin-releasing hormone (GnRH) neurons are the central regulators of reproductive function in all mammals. The cell bodies of GnRH neurons are unique in that they are not confined to a discrete nucleus, but rather ...
A role for alpha-7 nAChRs at cerebellar synapses
The cerebellum performs a well-known motor control function but accumulating evidence supports its role in cognitive functions. The nicotinic cholinergic system alters cognition through its actions elsewhere in the brain ...
Prolactin Regulation of Kisspeptin Neurons
It is well established in both humans and rodents that the state of hyperprolactinaemia leads to reduced reproductive capacity, as a consequence of suppressed luteinising hormone secretion. Return of reproductive function ...
Bowel Bacteria and Dendritic Cells in Ankylosing Spondylitis
Ankylosing Spondylitis (AS) is chronic inflammatory arthritis of spine and sacroiliac joints with further peripheral manifestations. AS is a relatively common rheumatic disease affecting 0.1- 1.4% of the population. Early ...
Understanding Batten disease: CLN5 expression in CLN6 deficient ovine neural cultures.
Neuronal Ceroid Lipofuscinoses (NCL) are a group of debilitating and fatal neurodegenerative diseases of childhood resulting from progressive brain atrophy. The human and ovine variant late infantile CLN6 (ceroid lipofuscinosis ...