Show simple item record

dc.contributor.advisorIreton, Keith
dc.contributor.authorLaw, Daria Rose
dc.date.available2013-11-21T02:05:01Z
dc.date.copyright2013
dc.identifier.citationLaw, D. R. (2013). Characterising the role of human mTOR in Listeria monocytogenes infection (Thesis, Bachelor of Biomedical Sciences with Honours). University of Otago. Retrieved from http://hdl.handle.net/10523/4481en
dc.identifier.urihttp://hdl.handle.net/10523/4481
dc.description.abstractThe pathogenic food bourne bacterium Listeria monocytogenes has the potential to cause gastroenteritis, meningitis and abortion in an infected individual. L. monocytogenes is a facultative intracellular bacterium that facilitates its internalisation into some host cells by binding of the bacterial surface protein InlB with its cognate human receptor, the receptor tyrosine kinase Met. This binding stimulates a number of cellular signaling events, which ultimately lead to host cell membrane rearrangement and engulfment of the bacterium. One human signaling protein the Mammalian target of Rapamycin (mTOR) was recently shown to be important in the InlB mediated internalisation of L. monocytogenes. However the molecular mechanism underlying mTOR’s role in internalisation is not understood. Using an RNA interference based method, this project set out to elucidate which components of mTOR are important in L. monocytogenes internalisation into the human epithelial cell line HeLa. Here we find that the mammalian target of rapamycin complex 2 (mTORC2) and its downstream substrate PKC-α are involved in the InlB mediated internalisation of L. monocytogenes into the epithelial cell line HeLa.
dc.language.isoen
dc.publisherUniversity of Otago
dc.rightsAll items in OUR Archive are provided for private study and research purposes and are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectListeria
dc.subjectmonocytogenes
dc.subjectmTOR
dc.subjectPI3K
dc.subjectmTORC1
dc.subjectmTORC2
dc.subjectPKC
dc.subjectfood
dc.subjectbourne
dc.subjectbacteria
dc.titleCharacterising the role of human mTOR in Listeria monocytogenes infection
dc.typeThesis
dc.date.updated2013-11-21T00:56:48Z
dc.language.rfc3066en
thesis.degree.disciplineMicrobiology and Immunology
thesis.degree.nameBachelor of Biomedical Sciences with Honours
thesis.degree.grantorUniversity of Otago
thesis.degree.levelHonours
otago.interloanno
otago.openaccessAbstract Only
 Find in your library

Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item is not available in full-text via OUR Archive.

If you are the author of this item, please contact us if you wish to discuss making the full text publicly available.

This item appears in the following Collection(s)

Show simple item record