Influence of covariates on treatment outcome in placebo-controlled trials of benzodiazepines in GAD
Gale, Christopher; Glue, Paul; Wilkinson, Sam; McMurdo, Maave; Rapsey, Charlene; Coverdale, John; Guaiana, Giuseppe
Benzodiazepines are commonly used for anxiety disorders, but there is a lack of systematic reviews relating to their safety and efficacy. A Cochrane Review is in preparation comparing beizodiazepines with placebo and preliminary data indicates that benzodiazepines have a significantly higher response rate and a significantly lower drop-out rate, but at the cost of more side effects. One of the issues is that there is a moderate to high rate of heterogeneity, with I-squared values estimated at between 20% (for side effects)to 91% (for HAM-A). We will be presenting sensitivity analyses of these results, looking at the year of publication, diagnostic criteria, dose effects, and baseline severity.
Conference: Mental Health Research -- the Whole Picture. The Australian Society for Psychiatric Research (ASPR) 2013 Conference., Melbourne, Victoria
Keywords: Benzodiazepine; Placebo; Severity; Generalized Anxiety Disorder; Meta analysis
Research Type: Conference or Workshop Item (Poster)
There was a variation in the subject and title from abstract submission to poster with the poster concentrating far more explicitly on modelling the causation of heterogeneity within the database of RCTs.
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