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dc.contributor.advisorBenuskova, Lubica
dc.contributor.authorHananeia, Nicholas
dc.date.available2015-03-01T19:43:52Z
dc.date.copyright2015
dc.identifier.citationHananeia, N. (2015). Computational Modelling of Synaptic Plasticity in the Dentate Gyrus Granule Cell (Thesis, Master of Science). University of Otago. Retrieved from http://hdl.handle.net/10523/5482en
dc.identifier.urihttp://hdl.handle.net/10523/5482
dc.description.abstractAfter more than 30 years of study, the dynamics of synaptic plasticity in neurons still remain somewhat a mystery. By conducting a series of simulations on a simulated version of the rat dentate gyrus granule cell usingthe Izhikevich spiking neuron model, we compare and contrast several potential synaptic plasticity rules' applicability to the same experiment. Based on a 2001 experiment (Abraham et al., 2001), our simulations find that spike timing dependent plasticity (STDP), a more recent (Markram et al., 1997) theory of synaptic plasticity, is insufficient to replicate the heterosynaptic LTD shown in the experiment without including aspects of the significantly older Bienenstock-Cooper-Munro (BCM)(Bienenstock et al., 1982) theory. A combination of the history-independent STDP model and the historydependent BCM model seems most likely to be an accurate candidate for reproducing the greatest variety of cell dynamics. We also findthat in simpler nearest-neighbour STDP rules, the choice of pairing scheme is critical in achieving the greatest concordance with experiment.
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherUniversity of Otago
dc.rightsAll items in OUR Archive are provided for private study and research purposes and are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectcomputational neuroscience
dc.subjectSTDP
dc.subjectBCM
dc.subjectspike timing dependent plasticity
dc.subjectmetaplasticity
dc.subjectdentate gyrus granule cell
dc.subjectgranule cell
dc.subjectneuroscience
dc.subjectheterosynaptic
dc.subjectLTP
dc.subjectLTD
dc.titleComputational Modelling of Synaptic Plasticity in the Dentate Gyrus Granule Cell
dc.typeThesis
dc.date.updated2015-02-27T08:42:18Z
dc.language.rfc3066en
thesis.degree.disciplineComputer Science
thesis.degree.nameMaster of Science
thesis.degree.grantorUniversity of Otago
thesis.degree.levelMasters
otago.openaccessOpen
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