Surgical Sciences

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Management of Osteoarthritis: A guide to non-surgical intervention

Abbott, J. Haxby (Book, 2014)

The MOA trial (Management of Osteoarthritis, or Maimoatanga Mate Köiwi) was a randomised clinical trial that aimed to investigate the long-term effectiveness and cost-effectiveness of both a multi-modal, individualised, ...
Stress Conditioning for Peripheral Arterial Disease

Thomas, Kate Nicole (Thesis, Doctor of Philosophy, 2016)

Exercise is important for maintaining health, and for the prevention and treatment of many cardiovascular diseases. Unfortunately, some individuals face significant barriers to exercise. Patients with peripheral arterial ...
Access to elective and acute orthopaedic surgery in Dunedin: an analysis of surgical delay

Ramage, Dean James (Thesis, Bachelor of Medical Science with Honours, 2016)

Background: Delay in surgical intervention may lead to significant personal, medical and economical consequences. For individuals undergoing treatment in the public health system, there is inevitably a delay in access to ...
The Role of Gabapentin in Postoperative Pain Following Tonsillectomy

Sanders, James Gerald (Thesis, Master of Medical Science, 2016)

Background Despite the many different surgical techniques and medical therapies, tonsillectomy continues to cause significant discomfort to patients. The literature has shown that gabapentin has been beneficial in painful ...
Time to Safe Driving after Total Hip and Knee Replacement Surgery

Meffan, Peter (Thesis, Bachelor of Medical Science with Honours, 2015)

Introduction: Osteoarthritis is the most common form of arthritis in the western world. With its increasing prevalence, total joint replacement is in high demand. After total hip replacement (THR) and total knee replacement ...
The microRNA profile of aortic stenosis

Coffey, Sean (Thesis, Doctor of Philosophy, 2015)

Background Valvular heart disease (VHD), especially aortic stenosis (AS), is an important cause of morbidity and mortality, but no medical therapies currently exist for most forms of VHD. The only treatment available for ...
Biomarkers for abdominal aortic aneurysm

Jin, Cao (Thesis, Doctor of Philosophy, 2015)

i Abstract Background Abdominal aortic aneurysm (AAA) represents a significant health burden, affecting approximately 4% of men over the age of 65 years in western countries. To date, no clinically useful circulating ...
Rib Fractures in Infants: Retrospective Survey of Fractures and Biomechanical Study.

Blackburne, William Bligh (Thesis, Bachelor of Medical Science with Honours, 2015)

Literature suggests that rib fractures are highly associated with abuse and the present understanding is that antero-posterior compression associated with the ‘shaken baby syndrome’ is their cause. However, this mechanism ...
Circulating MicroRNAs in Bariatric Surgery

Chan, Cheng Yee (Thesis, Master of Medical Science, 2014)

Obese patients who undergo gastric bypass surgery experience metabolic changes resulting in appetite loss and the apparent disappearance of type II diabetes within days to weeks, even before weight loss occurs. The ...
Ballistic Skeletal Injuries: An Experimental Study of the Orthopaedic, Biomechanic and Forensic Characteristics

Kieser, David Christopher (Thesis, Doctor of Philosophy, 2014)

We have just survived the most violent century in history. Ballistic skeletal injuries continue to kill or injure hundreds of thousands of people globally every year and yet our knowledge of these injuries remains ...
The Parapharyngeal Compartment and its Fascial Relations

Guidera, Alice K (Thesis, Master of Medical Science, 2013)

Introduction An accurate understanding of the arrangement of cervical fascia and its associated compartments is essential for differential diagnosis, predicting the spread of disease and surgical management. As surgical ...
Pathway based-approach for analysis of the New Zealand genome-wide association study in abdominal aortic aneurysm

Yu, Zhuo (Grace) (Thesis, Doctor of Philosophy, 2013)

Background: Abdominal aortic aneurysm (AAA) is a life-threatening disease with a strong genetic component that predominantly affects elderly males. Previous genome-wide association studies (GWAS) have identified a number ...
A novel set of condition-specific quality of life questionnaires in elective general surgical patient prioritization and outcome assessment

Chen, Tina Yen-Ting (Thesis, Doctor of Philosophy, 2012)

Health-related quality of life (QOL) has become an indispensible measure of health. It is an important patient-reported outcome (PRO) endpoint for elective surgery, and is one of the key factors in determining patient ...
Defining appropriateness of emergency department attendance: a New Zealand perspective

Richardson, Sandra Kathryn (Thesis, Doctor of Philosophy, 2012)

Aim: To explore NZ emergency medical and nursing staff understandings of Emergency Department (ED) 'appropriateness‘ in relation to patient presentations. Background: This study was developed in order to contribute to the ...
Prediction and Prevention of Complications in General Surgery

Woodfield, John Campbell (Thesis, Doctor of Philosophy, 2012)

This thesis examines two concepts that impact on surgical complications – prediction and prevention. The starting point was a randomised controlled trial (RCT) which compared the frequency and the cost of infection for two ...
Matrix metalloproteinases as predictive markers of coronary in-stent restenosis

Tarr, Gregory Patrick (Thesis, Doctor of Philosophy, 2012)

Background: Matrix metalloproteinases (MMPs) and the tissue inhibitors of matrix metalloproteinases (TIMPs) are involved in remodelling the extracellular matrix of the vascular system. Altered MMP expression has been ...
Anatomical and physiological characterization of a novel porcine model for varicose veins

Grant, Mark Wayne (Thesis, Master of Medical Science, 2012)

Varicose veins constitute a significant financial and social burden. Despite being well documented since Hippocrates, there is still a lack of understanding concerning both the underlying pathogenesis and the rationale of ...
Predicting the transition from acute to persistent low back pain in primary care

Melloh, Markus (Thesis, Doctor of Philosophy, 2012)

Low back pain (LBP) is by far the most prevalent and costly musculoskeletal problem in our society today. Most people experience an episode of LBP at least once in their lifetime. Some of them go on to develop persistent ...
Sildenafil in the treatment of fat embolism: a rat model

Jepegnanam, Thilak Samuel (Thesis, Master of Medical Science, 2012)

ABSTRACT Background: Sudden, peri-operative cardiovascular deterioration with decreased systemic arterial pressure and increased pulmonary arterial pressure is a potentially fatal complication ...
Identifying Inflammatory Markers in Vascular Disease

Meikle, Felicity (Thesis, Master of Medical Science, 2012)

Introduction: Cardiovascular disease remains the leading cause of death and disability globally. There has been much interest into the role that inflammation plays in the pathogenesis of cardiovascular disease. The ...