Pathology collection - Dunedin
Recent Deposits
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YB-1 oncoprotein in cancer and drug resistance
Y-box-binding protein 1 (YB-1) is a biomarker that is predictive of poor prognosis in cancer. Various molecular functions of YB-1 in cancer have been proposed, including the transcriptional regulation of gene expression. ... -
Molecular Analysis of Triple Negative Breast cancer
Triple negative breast cancer (TNBC) is a heterogeneous and aggressive subtype making up 10-20% of newly diagnosed invasive breast cancers and currently has no targeted agents approved for systemic therapy. However up to ... -
Peroxiredoxin expression and redox state in human cancers
Peroxiredoxins (Prxs) are a class of ubiquitous peroxidases that degrade hydrogen peroxide. They are found in almost all compartments of the cell: Prxs 1 and 2 in the cytosol, and Prx 3 in the mitochondria. Their role in ... -
HPV regulation of immunity in persistence and regression
High-risk human papillomavirus (HPV) infection leads to the development of several human cancers that cause significant morbidity and mortality worldwide. Cervical cancer is the most prevalent type of HPV-caused cancers ... -
Influence of the p53 isoform, delta133p53, on cytoskeletal dynamics during the initiation of migration
The well-known tumour suppressor p53 is known to prevent the development of tumours. Recent research has highlighted the importance of an N-truncated isoform, Δ133p53, in the progression of metastatic cancers. This particular ... -
Determining the best combination of TLR Agonist and Tumour Peptide for Cancer Vaccination
Immunotherapy has revolutionised the treatment of cancer in recent years; significantly improving patient response and long-term survival. Though many immunotherapies focus on increasing the effector function of immune ... -
The Cytotoxicity and Action of Curcumin Derivatives against Fn14+ Triple Negative Breast Cancer through repression of NF-κB p65
Triple negative breast cancer (TNBC) is an aggressive subtype of the disease which lacks options for targeted systemic therapies due to a lack of actionable clinical targets. Molecular analysis has revealed that Fn14, a ... -
p16INK4A polymorphism and ANRIL expression in human breast cancer
Overview: Breast cancer is the second most prevalent cancer in New Zealand with a largely unclear genetic etiology. Recent progress has demonstrated that expression of tumour suppressor proteins is regulated by long ... -
Immunomodulation and Vaccination with RHDV VLP
Colorectal cancer (CRC) is an insidious disease, responsible for almost 700,000 deaths annually worldwide. The incidence of CRC in New Zealand is more than double the world average, at 48.1 and 36.7 cases per 100,000 ... -
Modulation of DNA methylation by L-ascorbate and 5-aza-2’-deoxycytidine in murine embryonic stem cells
Cytosine methylation, normally found on cytosine residues adjacent to guanine (i.e., a CpG dinucleotide), is one means by which long-term gene repression occurs. Immediately after semi-conservative DNA replication, CpG ... -
Investigating the anti-invasive properties of dexamethasone in Fn14 positive triple negative breast cancer.
Triple-negative breast cancer (TNBC) is an aggressive disease subtype with no current targeted systemic therapies due to a lack of actionable molecular targets. Efforts to identify therapeutic targets in TNBC have revealed ... -
The mouse mutant ∆122p53, a model of the ∆133p53 isoform, promotes migration and metastasis
The tumour suppressor gene p53 is the master sensor and regulator of the response to cell stress. Upon DNA damage, p53 can induce various outcomes including apoptosis, cell cycle arrest, senescence, and DNA repair in order ... -
Two Heads Are Better Than One: The Combination of Dendritic Cells & B Cells Yields An Improved T Cell Response Over Dendritic Cells Alone When Presenting Tumour Lysate Antigens
BACKGROUND The best APC for tumour immunotherapy is yet to be defined. The dendritic cell (DC) is well established as the key professional antigen-presenting cell (APC) for priming naïve T cells against tumours and for ... -
RRBS and the Epigenetic Effects of Steroids in ALL
Acute lymphoblastic leukaemia (ALL) is a malignant proliferation of immature lymphocytes, mainly occurring in childhood. The pathogenesis of the disease is characterised by multiple molecular abnormalities, including ... -
p53 and B Cell Fate
The tumour suppressor protein p53 is one of the most well-known and well-studied proteins, with a vast amount of research dedicated to understand its role in tumour formation. Despite this, little is known about its function ... -
Chemically induced DNA hemimethylation and active demethylation
The inheritance of epigenetic signals involves DNA methylation. DNA methylation patterns are inherited through cell generations by the action of DNA methyltransferases (DNMTs). During DNA replication DNMTs recognise ... -
Transcriptional regulation of the Runx1 gene
Runx1 is crucial for blood cell development and is one of the genes most frequently translocated or mutated in leukaemia, thereby contributing to disease pathogenesis. Runx1 is transcribed from two promoters, P1 and P2, ... -
Effect of cystathionine-gamma-lyase gene silencing with siRNA on inflammation in acute pancreatitis
Hydrogen sulfide (H2S) is an endogenous inflammatory mediator produced by the activity of cystathionine γ–lyase (CSE) in mammals. Macrophages are a key element of the immune system and play a crucial role in inflammation. ... -
Development of a new microparticle vaccine adjuvant with the ability to deliver peptides and siRNAs to Dendritic Cells in order to boost the immune response
Recently, new discoveries in the field of cancer immunology have been able to increase the strength of immune responses against tumors. For example, monoclonal antibodies such as Ipilimumab and Nivolumab are able to ... -
Searching for a Functional Variant in a Non-Coding Genomic Region Associated with Serum Urate
Gout was historically known as the king of diseases and disease of kings, reserved for those of wealthy, extravagant lifestyles. Far from being resigned to history books, gout is on the rise worldwide and in New Zealand – ...