Pathology collection - Dunedin
Recent Deposits
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HPV 16 E6/E7 expressing microparticles alter functional phenotype of Langerhans cell-like cells
High-risk human papillomavirus (HPV) infections can lead to the development of cervical cancer, the fourth most common cancer in women worldwide. High-risk HPV type 16 (HPV16) is responsible for over 50% of cervical cancers ... -
The presence of ∆133p53 and ∆40p53 in metastatic brain tumours: evidence for further enquiries
Metastatic brain tumours are becoming more prevalent as individuals with primary cancers receive improved treatment and live longer. These brain tumours are difficult to treat and are often left undiagnosed. This study ... -
Investigating the Effects of Chronic Low-Grade Inflammation on Cancer Immunotherapy
Cancer is the leading cause of death in New Zealand and is responsible for approximately one third of all deaths. Due to various factors, including unhealthy life style choices and an aging population, the number of new ... -
Methylated Circulating Tumour DNA in Myeloma
Myeloma is an incurable malignancy of plasma cells in the bone marrow. Improvements in myeloma treatment have highlighted the need for more sensitive non-invasive measures of residual disease. Circulating tumour DNA in the ... -
Exploiting the Childhood Acute Lymphoblastic Leukaemia DNA Methylation Profile to Detect a Novel Population of Fetal Lymphocytes
Introduction: Childhood acute lymphoblastic leukaemia (ALL) is a disease that originates before birth and results from the proliferation of neoplastic lymphoid precursor cells in the bone marrow. In the majority of cases ... -
Genome-wide DNA Methylation and Gene Expression Analysis of Non-invasive and Invasive Melanoma Cell Lines
Melanoma is a serious form of skin cancer derived from the pigment producing cells called melanocytes. New Zealand has the highest rate of melanoma in the world with as high as 50 cases of melanoma per 100,000 people, ... -
Cohesin and CTCF in early zebrafish embryogenesis
Early embryonic development in metazoans is characterised by extensive changes in gene expression and chromatin remodelling at all levels. In most metazoans, zygotic genomes are transcriptionally ... -
YB-1 oncoprotein in cancer and drug resistance
Y-box-binding protein 1 (YB-1) is a biomarker that is predictive of poor prognosis in cancer. Various molecular functions of YB-1 in cancer have been proposed, including the transcriptional regulation of gene expression. ... -
Molecular Analysis of Triple Negative Breast cancer
Triple negative breast cancer (TNBC) is a heterogeneous and aggressive subtype making up 10-20% of newly diagnosed invasive breast cancers and currently has no targeted agents approved for systemic therapy. However up to ... -
Peroxiredoxin expression and redox state in human cancers
Peroxiredoxins (Prxs) are a class of ubiquitous peroxidases that degrade hydrogen peroxide. They are found in almost all compartments of the cell: Prxs 1 and 2 in the cytosol, and Prx 3 in the mitochondria. Their role in ... -
HPV regulation of immunity in persistence and regression
High-risk human papillomavirus (HPV) infection leads to the development of several human cancers that cause significant morbidity and mortality worldwide. Cervical cancer is the most prevalent type of HPV-caused cancers ... -
Influence of the p53 isoform, delta133p53, on cytoskeletal dynamics during the initiation of migration
The well-known tumour suppressor p53 is known to prevent the development of tumours. Recent research has highlighted the importance of an N-truncated isoform, Δ133p53, in the progression of metastatic cancers. This particular ... -
Determining the best combination of TLR Agonist and Tumour Peptide for Cancer Vaccination
Immunotherapy has revolutionised the treatment of cancer in recent years; significantly improving patient response and long-term survival. Though many immunotherapies focus on increasing the effector function of immune ... -
The Cytotoxicity and Action of Curcumin Derivatives against Fn14+ Triple Negative Breast Cancer through repression of NF-κB p65
Triple negative breast cancer (TNBC) is an aggressive subtype of the disease which lacks options for targeted systemic therapies due to a lack of actionable clinical targets. Molecular analysis has revealed that Fn14, a ... -
p16INK4A polymorphism and ANRIL expression in human breast cancer
Overview: Breast cancer is the second most prevalent cancer in New Zealand with a largely unclear genetic etiology. Recent progress has demonstrated that expression of tumour suppressor proteins is regulated by long ... -
Immunomodulation and Vaccination with RHDV VLP
Colorectal cancer (CRC) is an insidious disease, responsible for almost 700,000 deaths annually worldwide. The incidence of CRC in New Zealand is more than double the world average, at 48.1 and 36.7 cases per 100,000 ... -
Modulation of DNA methylation by L-ascorbate and 5-aza-2’-deoxycytidine in murine embryonic stem cells
Cytosine methylation, normally found on cytosine residues adjacent to guanine (i.e., a CpG dinucleotide), is one means by which long-term gene repression occurs. Immediately after semi-conservative DNA replication, CpG ... -
Investigating the anti-invasive properties of dexamethasone in Fn14 positive triple negative breast cancer.
Triple-negative breast cancer (TNBC) is an aggressive disease subtype with no current targeted systemic therapies due to a lack of actionable molecular targets. Efforts to identify therapeutic targets in TNBC have revealed ... -
The mouse mutant ∆122p53, a model of the ∆133p53 isoform, promotes migration and metastasis
The tumour suppressor gene p53 is the master sensor and regulator of the response to cell stress. Upon DNA damage, p53 can induce various outcomes including apoptosis, cell cycle arrest, senescence, and DNA repair in order ... -
Two Heads Are Better Than One: The Combination of Dendritic Cells & B Cells Yields An Improved T Cell Response Over Dendritic Cells Alone When Presenting Tumour Lysate Antigens
BACKGROUND The best APC for tumour immunotherapy is yet to be defined. The dendritic cell (DC) is well established as the key professional antigen-presenting cell (APC) for priming naïve T cells against tumours and for ...