Pathology collection - Dunedin
Recent Deposits
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Investigating the role of fibroblast growth factor inducible 14 in breast cancer
Breast cancer is the leading cause of cancer-associated death in women worldwide (1), largely due to metastatic disease progression. Fibroblast Growth Factor Inducible 14 (Fn14) is a type 1 transmembrane receptor and member ... -
Role of amiloride in lithium induced kidney interstitial fibrosis
Background Attenuating progressive fibrosis is fundamental to preventing chronic kidney disease and, ultimately, any accompanying end-stage kidney disease. Lithium treatment is associated with nephrogenic diabetes insipidus, ... -
The Interaction between YB-1, SEPT2, and β-Actin during Cancer Cell Proliferation and Migration
Elevated levels of the cold shock protein Y-Box binding protein 1 (YB-1) are associated with poor prognosis and a reduction in disease-free survival in many cancers including breast cancer. Recently, mass spectrometry data ... -
Tumour lysate-based immunotherapy for colorectal cancer
In New Zealand, the incidence and mortality rates of colorectal cancer (CRC) are among the highest worldwide. Despite drastic advances in our understanding of this disease, current treatments for metastatic CRC remain ... -
The Effects of Activin B and Activin C on the Growth and Migration of Prostate Cancer Cells
Prostate cancer (PCa) is the most diagnosed cancer in New Zealand men and is one of the leading causes of male cancer related death globally. Current diagnostic and prognostic tools for PCa are unable to differentiate ... -
Investigating the role of Fn14 expression in hormone receptor positive breast cancer
Breast cancer is the second leading cause of cancer death in women. Approximately 75% of invasive breast cancers are hormone receptor (HR) positive, and have the option to receive targeted endocrine therapy. However, a ... -
Investigation of a Wnt/Cohesin cause for Acute Myeloid Leukaemia (AML)
Cohesin is a multiprotein complex essential for cell division and three-dimensional genome organisation. Mutations in genes encoding the cohesin-subunits, particularly STAG2, are found in ~13% of acute myeloid leukaemia ... -
Transitioning from analysing methylation profiles in bulk populations of Colorectal cancer cells to methylation profiles of single cells
Colorectal cancer (CRC) is one of the leading causes of death by cancer in New Zealand, largely due to metastasis of the primary tumour to secondary sites around the body. The initiation, progression and eventual metastasis ... -
Understanding p53 in Cancer: The characteristics of uncommon TP53 missense mutations
p53 (TP53) is the most commonly mutated tumor suppressor in cancer. How mutant forms of p53 can contribute to disease progression to influence patient outcomes is important to understand. Previous in-vitro and in-vivo data ... -
Mitochondrial Structure and Function
The quality of an oocyte determines its ability to correctly undergo cytoplasmic and nuclear maturation, and this contributes to the success of the oocyte and future embryo. Advancements in our understanding of oocyte ... -
Characterisation of Drug Tolerant Persisters in Lung Adenocarcinoma
Lung cancer is the largest cause of cancer-related mortality worldwide and is the second most common cancer in New Zealand. By disproportionality impacting Māori and those who are most vulnerable in our community, lung ... -
Identification of vesicles, their contents, and how they may contribute to oocyte quality and female fertility
For decades oocyte organelles have undergone considerable investigation as a way to understand their contribution to reproductive competence. However, despite their frequent observation in oocyte studies, little attention ... -
Three-dimensional organisation of the Runx1 locus
The proper regulation of gene expression is crucial for cell-fate and lineage determination of hematopoietic stem cells (HSCs). Dysregulated expression of genes that drive haematopoietic differentiation can cause blood ... -
∆122p53 mice present persistent colitis following DSS treatment
Inflammatory bowel disease (IBD) is a leading health concern in New Zealand as it a lifelong condition that may cycle between periods of remission and relapse, often requiring extensive treatments and medical interventions. ... -
The Role of Large Extracellular Vesicles in Human Papillomavirus-Associated Immune Modulation of Langerhans Cells
Human papillomavirus type 16 (HPV16) is an oncogenic virus that infects basal keratinocytes of stratified squamous epithelium. Langerhans cells (LCs) reside within the stratified squamous epithelium and initiate immune ... -
Role of langerin+ cells in skin pathologies
Langerhans cells (LCs) are epidermal immune cells that express C-type lectin receptor langerin along with a subset of dermal dendritic cells. Langerin+ cells play a pivotal role in skin immunity. Previous research has ... -
Profiling the pregnancy-specific glycoprotein genes in pre-eclampsia.
Background: Pre-eclampsia (PE) is a hypertensive disorder of pregnancy which is characterised by reduced placental cell invasion into the maternal arteries. Lack of invasion causes insufficient transformation of arteries ... -
Targeted Epigenetic Editing Using a dCas9- SunTag Methylation System
DNA methylation is a stable and somatically heritable epigenetic process. It is classically understood as a gene silencing mechanism, whereby hypermethylation of gene promoters is largely associated with transcriptional ... -
DNA methylation in pre-eclampsia: methodologies and analytics
The placenta is a heterogeneous and multifunctional organ that grows and adapts according to increasing and fluctuating fetal demands in the intrauterine environment. As expected, the placenta plays a major role in pregnancy ... -
Investigating the Direct Role of Promoter DNA Methylation in Gene Expression using a Targeted TET1CD-dCas9 Demethylase Tool
DNA hypermethylation of gene promoter regions has long been associated with transcriptional repression. Furthermore, the establishment of dense promoter methylation within tumour- suppressor genes has been widely-characterised ...