Pathology collection - Dunedin
Recent Deposits
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Examining the role of cohesin subunit Rad21 in malignancy and development
The cohesin complex is essential for cell survival, owing to its well-established roles in cell division, DNA repair and gene expression. Malignancy and developmental disorders termed the cohesinopathies can result when ... -
Mechanisms of DNA demethylation
While every cell in an organism is genetically identical, there are marked phenotypic differences between tissues and organs that are controlled by epigenetic modifications. These epigenetic modifications provide an important ... -
Constitutive PD-L1 expression in melanoma
Treatment of melanoma based on targeted therapy and immunotherapy has dramatically advanced over the past decade. Advances in targeted therapy have been based on inhibition of the MAPK pathway while for immunotherapy, ... -
Investigating the Influence of Metabolic Syndrome on Cancer Immunotherapy
Cancer is a significant cause of morbidity in New Zealand, with breast and colorectal cancers being amongst the most commonly diagnosed. Therapeutic research has moved into immunotherapies, harnessing the immune system to ... -
Modeling RECQL4 developmental syndromes in Xenopus laevis using CRISPR/Cas9
There are a number of human genetic conditions of abnormal skeletal development associated with disrupted DNA replication, with several linked to mutations in RECQL4. While several mouse models targeting Recql4 have been ... -
Development of zebrafish models for leukaemia
Throughout development, numerous binary cell fate decisions are made where cells activate competing transcriptional networks and subsequently upregulate one network over others based on extrinsic cues. Cell fate decisions ... -
Identification of synthetic lethal compounds targeting cancers with cohesin mutations
The cohesin complex, comprising four core subunits, RAD21, SMC3, SMC1A, and STAG1/2, is important for the regulation of many biological processes, including sister chromatid cohesion, regulation of gene expression, chromatin ... -
Investigation into the relative location of filamin B and YB-1 in cell cycle progression
The cell cycle is a fundamental process in development and the maintenance of homeostasis. Various proteins regulate the cell cycle, such as Y-box binding protein -1 (YB-1). YB-1 transcriptionally regulates cell cycle ... -
Targeted Epigenetic Editing using a dCas9-SunTag Demethylation system
DNA methylation is a stable epigenetic modification, playing a critical role in the regulation of gene expression. Dysregulation of DNA methylation is implicated in the pathogenesis of numerous diseases including cancer. ... -
Regulation of Antigen Presenting Cells by Human Papillomavirus Small Extracellular Vesicles
Human Papillomavirus (HPV) causes over 99% of cervical cancer cases in the world, and of these, over 70% of cases can be attributed to high-risk HPV. There are prophylactic vaccines for HPV, that specifically target high-risk ... -
TP53 in renal vasculitis
Overview: Vasculitis is an autoimmune disease characterised by the swelling and inflammation of blood vessels. Renal vasculitis is a rare, yet severe disease characterised by the inflammation of glomeruli and affiliated ... -
Characterising the Functional and Molecular Determinants for Organ Selective Metastasis in Triple Negative Breast Cancer
Triple-negative breast cancer (TNBC) accounts for 10-20% of primary invasive breast cancer diagnoses, globally. With a higher risk of developing visceral and brain metastasis than other breast cancer subtypes, and limited ... -
The Expression of a p53 Isoform Δ133p53, in the Cell Cycle
Overview: p53 is a principal tumour suppressor protein that regulates the cell cycle. By doing so, p53 prevents damaged cells from undergoing DNA replication and cell division by activating pathways involved in DNA repair, ... -
Human papillomavirus gene expression in the placenta and its prevalence in an assisted reproduction cohort
Overview: Human papillomavirus (HPV) is well known as the leading cause of cervical cancer worldwide. Whether HPV also contributes to other adverse effects such as those associated with pregnancy is unclear. Higher incidences ... -
Genome-Wide DNA Methylation in Polycystic Kidney Disease
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a heritable renal disease that causes the enlargement of kidneys due to the bilateral development of fluid-filled cysts. This results in end-stage kidney disease in ... -
Investigation of Several Compounds for the Treatment of Autosomal Dominant Polycystic Kidney Disease
Polycystic kidney disease (PKD) is a leading cause of kidney failure, and one of the most prominent rare hereditary diseases in New Zealand, as well as globally. The autosomal dominant form of this disease (ADPKD) has a ... -
Cohesin and Regulation of Gene Expression During Zebrafish Development
Made up of four subunits, Structural Maintenance of Chromosomes (SMC) proteins, the SMC1 and SMC3 subunits, Rad21 and stromalin antigens (SA1/2), the ring- shaped protein cohesin is an essential part of both the mitotic ... -
HPV 16 E6/E7 expressing microparticles alter functional phenotype of Langerhans cell-like cells
High-risk human papillomavirus (HPV) infections can lead to the development of cervical cancer, the fourth most common cancer in women worldwide. High-risk HPV type 16 (HPV16) is responsible for over 50% of cervical cancers ... -
The presence of ∆133p53 and ∆40p53 in metastatic brain tumours: evidence for further enquiries
Metastatic brain tumours are becoming more prevalent as individuals with primary cancers receive improved treatment and live longer. These brain tumours are difficult to treat and are often left undiagnosed. This study ... -
Investigating the Effects of Chronic Low-Grade Inflammation on Cancer Immunotherapy
Cancer is the leading cause of death in New Zealand and is responsible for approximately one third of all deaths. Due to various factors, including unhealthy life style choices and an aging population, the number of new ...