Browsing Pathology collection - Dunedin by Title
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Gene Regulation by Drugs Used to Treat Mood Disorders
Mood disorders such as Major Depressive Disorder and Bipolar Disorder are devastating burdens upon sufferers, their families and society as a whole. Despite their high prevalence and socioeconomic impact, understanding the ... -
Genetic Analysis Of South Island Malignant Melanoma Cases
Greater understanding of the pathological mechanisms underlying recurrent driver mutations is revolutionising the clinical management of melanoma. However given the association between UV radiation and UV-associated DNA ... -
Genetics in the Pathogenesis and Treatment of Panic and Anxiety
Mental disorders form a broad category of disease that may manifest as emotional or behavioural changes. These disorders are common globally and account for a significant amount of morbidity. The most frequently occurring ... -
Genome-wide DNA Methylation and Gene Expression Analysis of Non-invasive and Invasive Melanoma Cell Lines
Melanoma is a serious form of skin cancer derived from the pigment producing cells called melanocytes. New Zealand has the highest rate of melanoma in the world with as high as 50 cases of melanoma per 100,000 people, ... -
Genome-Wide DNA Methylation in Polycystic Kidney Disease
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a heritable renal disease that causes the enlargement of kidneys due to the bilateral development of fluid-filled cysts. This results in end-stage kidney disease in ... -
HPV 16 E6/E7 expressing microparticles alter functional phenotype of Langerhans cell-like cells
High-risk human papillomavirus (HPV) infections can lead to the development of cervical cancer, the fourth most common cancer in women worldwide. High-risk HPV type 16 (HPV16) is responsible for over 50% of cervical cancers ... -
HPV regulation of immunity in persistence and regression
High-risk human papillomavirus (HPV) infection leads to the development of several human cancers that cause significant morbidity and mortality worldwide. Cervical cancer is the most prevalent type of HPV-caused cancers ... -
Human papillomavirus gene expression in the placenta and its prevalence in an assisted reproduction cohort
Overview: Human papillomavirus (HPV) is well known as the leading cause of cervical cancer worldwide. Whether HPV also contributes to other adverse effects such as those associated with pregnancy is unclear. Higher incidences ... -
Identification of synthetic lethal compounds targeting cancers with cohesin mutations
The cohesin complex, comprising four core subunits, RAD21, SMC3, SMC1A, and STAG1/2, is important for the regulation of many biological processes, including sister chromatid cohesion, regulation of gene expression, chromatin ... -
Immunomodulation and Vaccination with RHDV VLP
Colorectal cancer (CRC) is an insidious disease, responsible for almost 700,000 deaths annually worldwide. The incidence of CRC in New Zealand is more than double the world average, at 48.1 and 36.7 cases per 100,000 ... -
In situ expression of biomarkers in placenta in the context of hypertensive disorders of pregnancy
Overview: Hypertensive disorders in pregnancy (HDP), of which the most common is pre- eclampsia (PE), are a leading cause of maternal and foetal morbidity and mortality worldwide. Despite extensive research, no clear cause ... -
Influence of the p53 isoform, delta133p53, on cytoskeletal dynamics during the initiation of migration
The well-known tumour suppressor p53 is known to prevent the development of tumours. Recent research has highlighted the importance of an N-truncated isoform, Δ133p53, in the progression of metastatic cancers. This particular ... -
Investigating the anti-invasive properties of dexamethasone in Fn14 positive triple negative breast cancer.
Triple-negative breast cancer (TNBC) is an aggressive disease subtype with no current targeted systemic therapies due to a lack of actionable molecular targets. Efforts to identify therapeutic targets in TNBC have revealed ... -
Investigating the Direct Role of Promoter DNA Methylation in Gene Expression using a Targeted TET1CD-dCas9 Demethylase Tool
DNA hypermethylation of gene promoter regions has long been associated with transcriptional repression. Furthermore, the establishment of dense promoter methylation within tumour- suppressor genes has been widely-characterised ... -
Investigating the Effects of Chronic Low-Grade Inflammation on Cancer Immunotherapy
Cancer is the leading cause of death in New Zealand and is responsible for approximately one third of all deaths. Due to various factors, including unhealthy life style choices and an aging population, the number of new ... -
Investigating the function of cis-regulatory elements for Runx1
Detection of nucleotide sequence variations in patients of some diseases, provides strong evidence as to which genes and regulatory elements play a critical role in vivo. Acute Myeloid Leukaemia (AML) is a fast acting blood ... -
Investigating the Influence of Metabolic Syndrome on Cancer Immunotherapy
Cancer is a significant cause of morbidity in New Zealand, with breast and colorectal cancers being amongst the most commonly diagnosed. Therapeutic research has moved into immunotherapies, harnessing the immune system to ... -
Investigation into the relative location of filamin B and YB-1 in cell cycle progression
The cell cycle is a fundamental process in development and the maintenance of homeostasis. Various proteins regulate the cell cycle, such as Y-box binding protein -1 (YB-1). YB-1 transcriptionally regulates cell cycle ... -
Investigation of Several Compounds for the Treatment of Autosomal Dominant Polycystic Kidney Disease
Polycystic kidney disease (PKD) is a leading cause of kidney failure, and one of the most prominent rare hereditary diseases in New Zealand, as well as globally. The autosomal dominant form of this disease (ADPKD) has a ... -
Linking cohesin-dependent transcription with cell pluripotency
Embryonic stem cells are pluripotent; they have the ability to form any cell type of the developing embryo. Due to their pluripotent nature there is a strong interest in understanding the biology of embryonic stem cells. ...