Browsing Pathology collection - Dunedin by Title
Now showing items 2-21 of 79
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Bioinformatic Approaches to Analysing RRBS Data in the Context of Pre-eclampsia
The placenta is a crucial element of human life. It sustains and enables the development from a small group of cells to a whole organism. The placenta is a unique organ that fulfils multiple roles, from delivery of oxygen ... -
Characterising the Functional and Molecular Determinants for Organ Selective Metastasis in Triple Negative Breast Cancer
Triple-negative breast cancer (TNBC) accounts for 10-20% of primary invasive breast cancer diagnoses, globally. With a higher risk of developing visceral and brain metastasis than other breast cancer subtypes, and limited ... -
Chemically induced DNA hemimethylation and active demethylation
The inheritance of epigenetic signals involves DNA methylation. DNA methylation patterns are inherited through cell generations by the action of DNA methyltransferases (DNMTs). During DNA replication DNMTs recognise ... -
Cohesin and CTCF in early zebrafish embryogenesis
Early embryonic development in metazoans is characterised by extensive changes in gene expression and chromatin remodelling at all levels. In most metazoans, zygotic genomes are transcriptionally ... -
Cohesin and Regulation of Gene Expression During Zebrafish Development
Made up of four subunits, Structural Maintenance of Chromosomes (SMC) proteins, the SMC1 and SMC3 subunits, Rad21 and stromalin antigens (SA1/2), the ring- shaped protein cohesin is an essential part of both the mitotic ... -
Constitutive PD-L1 expression in melanoma
Treatment of melanoma based on targeted therapy and immunotherapy has dramatically advanced over the past decade. Advances in targeted therapy have been based on inhibition of the MAPK pathway while for immunotherapy, ... -
Coupling the Adjuvant CpG Oligonucleotides to RHDV VLP
Immunotherapies have the potential to harness the immune system in order to target and clear cancer cells. One branch of immunotherapeutic research is the development of cancer vaccines. Virus-like particles (VLP) make ... -
Determining the best combination of TLR Agonist and Tumour Peptide for Cancer Vaccination
Immunotherapy has revolutionised the treatment of cancer in recent years; significantly improving patient response and long-term survival. Though many immunotherapies focus on increasing the effector function of immune ... -
Development of a new microparticle vaccine adjuvant with the ability to deliver peptides and siRNAs to Dendritic Cells in order to boost the immune response
Recently, new discoveries in the field of cancer immunology have been able to increase the strength of immune responses against tumors. For example, monoclonal antibodies such as Ipilimumab and Nivolumab are able to ... -
Development of zebrafish models for leukaemia
Throughout development, numerous binary cell fate decisions are made where cells activate competing transcriptional networks and subsequently upregulate one network over others based on extrinsic cues. Cell fate decisions ... -
DISC1 in Psychiatric Illness
Major psychiatric illnesses including bipolar disorder and schizophrenia can be highly debilitating and collectively have a lifetime incidence of approximately 1% in the general population. Twin and adoption studies have ... -
DNA methylation in pre-eclampsia: methodologies and analytics
The placenta is a heterogeneous and multifunctional organ that grows and adapts according to increasing and fluctuating fetal demands in the intrauterine environment. As expected, the placenta plays a major role in pregnancy ... -
Effect of cystathionine-gamma-lyase gene silencing with siRNA on inflammation in acute pancreatitis
Hydrogen sulfide (H2S) is an endogenous inflammatory mediator produced by the activity of cystathionine γ–lyase (CSE) in mammals. Macrophages are a key element of the immune system and play a crucial role in inflammation. ... -
Enhancing Adoptive Cell Transfer for the Treatment of Cancer
Cancer is currently the leading cause of death in New Zealand, accounting for 30% of all deaths in 2010. Due to factors such as an ageing population and poor lifestyle choices, the incidence and mortality of this disease ... -
An Epigenetic Analysis of the Human Placenta
The human placenta is a highly specialized organ that is responsible for the survival of pregnancy. During its development, placental trophoblast cells invade into the uterine wall to establish a blood supply for the growing ... -
Epigenetics and Expression of SFRP1 and PPARG and Epigenetic Effects of Glucocorticoids in B-cell Acute Lymphoblastic Leukaemia
B-cell Acute Lymphoblastic Leukaemia (B-ALL), a cancer of immature B-lymphocytes, is the most common cancer in childhood. This cancer is characterised by widespread abnormalities of DNA methylation, when compared with ... -
Examining the role of cohesin subunit Rad21 in malignancy and development
The cohesin complex is essential for cell survival, owing to its well-established roles in cell division, DNA repair and gene expression. Malignancy and developmental disorders termed the cohesinopathies can result when ... -
Exploiting the Childhood Acute Lymphoblastic Leukaemia DNA Methylation Profile to Detect a Novel Population of Fetal Lymphocytes
Introduction: Childhood acute lymphoblastic leukaemia (ALL) is a disease that originates before birth and results from the proliferation of neoplastic lymphoid precursor cells in the bone marrow. In the majority of cases ... -
Gene expression and genetic association in bipolar disorder
Bipolar disorder is a serious psychiatric condition characterised by alternating episodes of major depression with mania or hypomania. The condition is relatively common, affecting 2-3% of the general population, and is ... -
Gene Regulation by Drugs Used to Treat Mood Disorders
Mood disorders such as Major Depressive Disorder and Bipolar Disorder are devastating burdens upon sufferers, their families and society as a whole. Despite their high prevalence and socioeconomic impact, understanding the ...