Browsing Pathology collection - Dunedin by Title
Now showing items 29-48 of 79
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Identification of synthetic lethal compounds targeting cancers with cohesin mutations
The cohesin complex, comprising four core subunits, RAD21, SMC3, SMC1A, and STAG1/2, is important for the regulation of many biological processes, including sister chromatid cohesion, regulation of gene expression, chromatin ... -
Immunomodulation and Vaccination with RHDV VLP
Colorectal cancer (CRC) is an insidious disease, responsible for almost 700,000 deaths annually worldwide. The incidence of CRC in New Zealand is more than double the world average, at 48.1 and 36.7 cases per 100,000 ... -
In situ expression of biomarkers in placenta in the context of hypertensive disorders of pregnancy
Overview: Hypertensive disorders in pregnancy (HDP), of which the most common is pre- eclampsia (PE), are a leading cause of maternal and foetal morbidity and mortality worldwide. Despite extensive research, no clear cause ... -
Influence of the p53 isoform, delta133p53, on cytoskeletal dynamics during the initiation of migration
The well-known tumour suppressor p53 is known to prevent the development of tumours. Recent research has highlighted the importance of an N-truncated isoform, Δ133p53, in the progression of metastatic cancers. This particular ... -
Investigating the anti-invasive properties of dexamethasone in Fn14 positive triple negative breast cancer.
Triple-negative breast cancer (TNBC) is an aggressive disease subtype with no current targeted systemic therapies due to a lack of actionable molecular targets. Efforts to identify therapeutic targets in TNBC have revealed ... -
Investigating the Direct Role of Promoter DNA Methylation in Gene Expression using a Targeted TET1CD-dCas9 Demethylase Tool
DNA hypermethylation of gene promoter regions has long been associated with transcriptional repression. Furthermore, the establishment of dense promoter methylation within tumour- suppressor genes has been widely-characterised ... -
Investigating the Effects of Chronic Low-Grade Inflammation on Cancer Immunotherapy
Cancer is the leading cause of death in New Zealand and is responsible for approximately one third of all deaths. Due to various factors, including unhealthy life style choices and an aging population, the number of new ... -
Investigating the function of cis-regulatory elements for Runx1
Detection of nucleotide sequence variations in patients of some diseases, provides strong evidence as to which genes and regulatory elements play a critical role in vivo. Acute Myeloid Leukaemia (AML) is a fast acting blood ... -
Investigating the Influence of Metabolic Syndrome on Cancer Immunotherapy
Cancer is a significant cause of morbidity in New Zealand, with breast and colorectal cancers being amongst the most commonly diagnosed. Therapeutic research has moved into immunotherapies, harnessing the immune system to ... -
Investigation into the relative location of filamin B and YB-1 in cell cycle progression
The cell cycle is a fundamental process in development and the maintenance of homeostasis. Various proteins regulate the cell cycle, such as Y-box binding protein -1 (YB-1). YB-1 transcriptionally regulates cell cycle ... -
Investigation of Several Compounds for the Treatment of Autosomal Dominant Polycystic Kidney Disease
Polycystic kidney disease (PKD) is a leading cause of kidney failure, and one of the most prominent rare hereditary diseases in New Zealand, as well as globally. The autosomal dominant form of this disease (ADPKD) has a ... -
Linking cohesin-dependent transcription with cell pluripotency
Embryonic stem cells are pluripotent; they have the ability to form any cell type of the developing embryo. Due to their pluripotent nature there is a strong interest in understanding the biology of embryonic stem cells. ... -
Mechanisms of DNA demethylation
While every cell in an organism is genetically identical, there are marked phenotypic differences between tissues and organs that are controlled by epigenetic modifications. These epigenetic modifications provide an important ... -
Methods for Exploiting the Childhood Acute Lymphoblastic Leukaemia DNA Methylation Profile to Detect a Novel Population of Fetal Lymphocytes
The incidence of childhood acute lymphoblastic leukaemia (B-ALL) has increased since 1950s worldwide. The disease affects young children and it has physical and psychosocial impacts on children and their families. Different ... -
Methylated Circulating Tumour DNA in Myeloma
Myeloma is an incurable malignancy of plasma cells in the bone marrow. Improvements in myeloma treatment have highlighted the need for more sensitive non-invasive measures of residual disease. Circulating tumour DNA in the ... -
Modeling RECQL4 developmental syndromes in Xenopus laevis using CRISPR/Cas9
There are a number of human genetic conditions of abnormal skeletal development associated with disrupted DNA replication, with several linked to mutations in RECQL4. While several mouse models targeting Recql4 have been ... -
Modulation of DNA methylation by L-ascorbate and 5-aza-2’-deoxycytidine in murine embryonic stem cells
Cytosine methylation, normally found on cytosine residues adjacent to guanine (i.e., a CpG dinucleotide), is one means by which long-term gene repression occurs. Immediately after semi-conservative DNA replication, CpG ... -
Molecular Analysis of Triple Negative Breast cancer
Triple negative breast cancer (TNBC) is a heterogeneous and aggressive subtype making up 10-20% of newly diagnosed invasive breast cancers and currently has no targeted agents approved for systemic therapy. However up to ... -
Multiple Dosing of RHDV VLP to Enhance the Anti-tumour Response
Metastatic melanoma has a poor prognosis, with a median survival of 13 months after diagnosis. New Zealand has among the highest melanoma rates in the world with more than 2000 cases registered every year. Metastatic ... -
Mutant p53 and pro-inflammatory gene expression in colorectal cancer cells
p53 gene is the most commonly mutated gene in cancer, and in many malignancies a loss of p53 promotes cancer progression. However recent evidence has shown that missense mutations in p53, particularly those that lead to ...