Browsing Pathology collection - Dunedin by Title
Now showing items 40-59 of 79
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Linking cohesin-dependent transcription with cell pluripotency
Embryonic stem cells are pluripotent; they have the ability to form any cell type of the developing embryo. Due to their pluripotent nature there is a strong interest in understanding the biology of embryonic stem cells. ... -
Mechanisms of DNA demethylation
While every cell in an organism is genetically identical, there are marked phenotypic differences between tissues and organs that are controlled by epigenetic modifications. These epigenetic modifications provide an important ... -
Methods for Exploiting the Childhood Acute Lymphoblastic Leukaemia DNA Methylation Profile to Detect a Novel Population of Fetal Lymphocytes
The incidence of childhood acute lymphoblastic leukaemia (B-ALL) has increased since 1950s worldwide. The disease affects young children and it has physical and psychosocial impacts on children and their families. Different ... -
Methylated Circulating Tumour DNA in Myeloma
Myeloma is an incurable malignancy of plasma cells in the bone marrow. Improvements in myeloma treatment have highlighted the need for more sensitive non-invasive measures of residual disease. Circulating tumour DNA in the ... -
Modeling RECQL4 developmental syndromes in Xenopus laevis using CRISPR/Cas9
There are a number of human genetic conditions of abnormal skeletal development associated with disrupted DNA replication, with several linked to mutations in RECQL4. While several mouse models targeting Recql4 have been ... -
Modulation of DNA methylation by L-ascorbate and 5-aza-2’-deoxycytidine in murine embryonic stem cells
Cytosine methylation, normally found on cytosine residues adjacent to guanine (i.e., a CpG dinucleotide), is one means by which long-term gene repression occurs. Immediately after semi-conservative DNA replication, CpG ... -
Molecular Analysis of Triple Negative Breast cancer
Triple negative breast cancer (TNBC) is a heterogeneous and aggressive subtype making up 10-20% of newly diagnosed invasive breast cancers and currently has no targeted agents approved for systemic therapy. However up to ... -
Multiple Dosing of RHDV VLP to Enhance the Anti-tumour Response
Metastatic melanoma has a poor prognosis, with a median survival of 13 months after diagnosis. New Zealand has among the highest melanoma rates in the world with more than 2000 cases registered every year. Metastatic ... -
Mutant p53 and pro-inflammatory gene expression in colorectal cancer cells
p53 gene is the most commonly mutated gene in cancer, and in many malignancies a loss of p53 promotes cancer progression. However recent evidence has shown that missense mutations in p53, particularly those that lead to ... -
The natural history of autoimmune disorders in mice and its modification by therapy
The main aim of this thesis is to study from a clinicopathological aspect the pattern of development and the nature of lesions, particularly renal ones, in NZB/BL X NZW hybrid mice. Groups of these mice were assessed ... -
Oestrogen-dependent regulation of gene expression by cohesin in breast cancer
Two-thirds of human breast carcinomas test positive for oestrogen receptor α (ERα), which predominantly mediates oestrogenic actions in the normal breast as well in breast tumour cells. Treatment of hormone-sensitive tumours ... -
p16INK4A polymorphism and ANRIL expression in human breast cancer
Overview: Breast cancer is the second most prevalent cancer in New Zealand with a largely unclear genetic etiology. Recent progress has demonstrated that expression of tumour suppressor proteins is regulated by long ... -
p53 and B Cell Fate
The tumour suppressor protein p53 is one of the most well-known and well-studied proteins, with a vast amount of research dedicated to understand its role in tumour formation. Despite this, little is known about its function ... -
Pathogenicity Studies of the Ciliopathy Gene, MKS3, in Zebrafish Embryos
Polycystic kidney disease (PKD) is a genetic disorder that affects between 1 in 400 to in 1000 people worldwide. PKD is a ciliopathy and is characterized by fluid-filled cysts that form in both kidneys, causing significant ... -
Peripheral lobular necrosis in hepatitis
Foreword: In recent years knowledge of the clinical and pathological features of hepatitis has so increased that the disease has now become the subject of reviews (e.g: Sodeman 1946, Editorial, Ann. Int. Med. 1946, Dible ... -
Peroxiredoxin expression and redox state in human cancers
Peroxiredoxins (Prxs) are a class of ubiquitous peroxidases that degrade hydrogen peroxide. They are found in almost all compartments of the cell: Prxs 1 and 2 in the cytosol, and Prx 3 in the mitochondria. Their role in ... -
Phenotyping Langerhans cell like cell treated with microparticles from keratinocytes expressing human papilloma viruse16 E7 oncoprotein
Cervical cancer in females is a worldwide health issue. High risk subtype of human papilloma viruses (HPV) are involved as a major risk factor. HPV oncogenes, E7 and E6 which are over-expressed in the host cells and promote ... -
Profiling the pregnancy-specific glycoprotein genes in pre-eclampsia.
Background: Pre-eclampsia (PE) is a hypertensive disorder of pregnancy which is characterised by reduced placental cell invasion into the maternal arteries. Lack of invasion causes insufficient transformation of arteries ... -
Radical Development: the developmental consequences of oxidative stress in zebrafish
Oxidative stress, an imbalance in the cellular redox systems, could be a major influence on organism development. To investigate this possibility I carried out basic research into the antioxidant systems in the zebrafish ... -
Reduced Representation Bisulfite Sequencing of Human Neutrophils Reveals Widespread Inter-Individual Epigenetic Variation
Methylation of DNA molecules is a fundamental mechanism for regulating gene function that is prevalent in all vertebrates. Although, the role of DNA methylation is well recognised in the disease context, the knowledge of ...