Browsing Pathology collection - Dunedin by Title
Now showing items 51-70 of 79
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p16INK4A polymorphism and ANRIL expression in human breast cancer
Overview: Breast cancer is the second most prevalent cancer in New Zealand with a largely unclear genetic etiology. Recent progress has demonstrated that expression of tumour suppressor proteins is regulated by long ... -
p53 and B Cell Fate
The tumour suppressor protein p53 is one of the most well-known and well-studied proteins, with a vast amount of research dedicated to understand its role in tumour formation. Despite this, little is known about its function ... -
Pathogenicity Studies of the Ciliopathy Gene, MKS3, in Zebrafish Embryos
Polycystic kidney disease (PKD) is a genetic disorder that affects between 1 in 400 to in 1000 people worldwide. PKD is a ciliopathy and is characterized by fluid-filled cysts that form in both kidneys, causing significant ... -
Peripheral lobular necrosis in hepatitis
Foreword: In recent years knowledge of the clinical and pathological features of hepatitis has so increased that the disease has now become the subject of reviews (e.g: Sodeman 1946, Editorial, Ann. Int. Med. 1946, Dible ... -
Peroxiredoxin expression and redox state in human cancers
Peroxiredoxins (Prxs) are a class of ubiquitous peroxidases that degrade hydrogen peroxide. They are found in almost all compartments of the cell: Prxs 1 and 2 in the cytosol, and Prx 3 in the mitochondria. Their role in ... -
Phenotyping Langerhans cell like cell treated with microparticles from keratinocytes expressing human papilloma viruse16 E7 oncoprotein
Cervical cancer in females is a worldwide health issue. High risk subtype of human papilloma viruses (HPV) are involved as a major risk factor. HPV oncogenes, E7 and E6 which are over-expressed in the host cells and promote ... -
Profiling the pregnancy-specific glycoprotein genes in pre-eclampsia.
Background: Pre-eclampsia (PE) is a hypertensive disorder of pregnancy which is characterised by reduced placental cell invasion into the maternal arteries. Lack of invasion causes insufficient transformation of arteries ... -
Radical Development: the developmental consequences of oxidative stress in zebrafish
Oxidative stress, an imbalance in the cellular redox systems, could be a major influence on organism development. To investigate this possibility I carried out basic research into the antioxidant systems in the zebrafish ... -
Reduced Representation Bisulfite Sequencing of Human Neutrophils Reveals Widespread Inter-Individual Epigenetic Variation
Methylation of DNA molecules is a fundamental mechanism for regulating gene function that is prevalent in all vertebrates. Although, the role of DNA methylation is well recognised in the disease context, the knowledge of ... -
Regulation of Antigen Presenting Cells by Human Papillomavirus Small Extracellular Vesicles
Human Papillomavirus (HPV) causes over 99% of cervical cancer cases in the world, and of these, over 70% of cases can be attributed to high-risk HPV. There are prophylactic vaccines for HPV, that specifically target high-risk ... -
Regulation of human PAX2 in cancer cells by Transforming Growth Factor-beta (TGF-β)
The PAired boX (PAX) family is a group of related genes that are highly conserved throughout evolution and are known to play important roles in mammalian development. So far nine members of the PAX gene family (PAX1-9) ... -
RHDV VLP Mediated Delivery of α-Galactosylceramide for Immunotherapy
The immune system has the potential to detect and destroy tumour cells, however naturally occurring anti-tumour immunity is not always capable of controlling tumour growth. Immunotherapy can harness the anti-tumour function ... -
Role of langerin+ cells in skin pathologies
Langerhans cells (LCs) are epidermal immune cells that express C-type lectin receptor langerin along with a subset of dermal dendritic cells. Langerin+ cells play a pivotal role in skin immunity. Previous research has ... -
RRBS and the Epigenetic Effects of Steroids in ALL
Acute lymphoblastic leukaemia (ALL) is a malignant proliferation of immature lymphocytes, mainly occurring in childhood. The pathogenesis of the disease is characterised by multiple molecular abnormalities, including ... -
Searching for a Functional Variant in a Non-Coding Genomic Region Associated with Serum Urate
Gout was historically known as the king of diseases and disease of kings, reserved for those of wealthy, extravagant lifestyles. Far from being resigned to history books, gout is on the rise worldwide and in New Zealand – ... -
Some aspects of prostatic cytology
Since the publication in 1943 of Papanicolau and Traut’s monograph on vaginal cytology, much attention has been focussed on the cells, both normal and neoplastic, exfoliating from almost every body surface. From the ... -
Targeted Epigenetic Editing Using a dCas9- SunTag Methylation System
DNA methylation is a stable and somatically heritable epigenetic process. It is classically understood as a gene silencing mechanism, whereby hypermethylation of gene promoters is largely associated with transcriptional ... -
Targeted Epigenetic Editing using a dCas9-SunTag Demethylation system
DNA methylation is a stable epigenetic modification, playing a critical role in the regulation of gene expression. Dysregulation of DNA methylation is implicated in the pathogenesis of numerous diseases including cancer. ... -
The Accuracy of Manual Fine Needle Aspiration Cytology in the Evaluation of Thyroid Cancer
Background The most common endocrine malignancy is thyroid carcinoma. Thyroid carcinoma constitutes for 0.5% of all cancer deaths. In New Zealand, thyroid carcinoma is less than 1% of all cancer registrations. In New ... -
The Alternative Lengthening of Telomeres Mechanism in Mesenchymal-derived Malignancies: A prognostic tool for Uterine Leiomyosarcoma and STUMP
Uterine smooth muscle tumours of uncertain malignant potential (STUMP) are diagnostically and clinically challenging. A mean to distinguish benign STUMP (leiomyoma) from malignant STUMP (leiomyosarcoma) is required. Chronic ...