Browsing Pathology collection - Dunedin by Title
Now showing items 58-77 of 79
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Radical Development: the developmental consequences of oxidative stress in zebrafish
Oxidative stress, an imbalance in the cellular redox systems, could be a major influence on organism development. To investigate this possibility I carried out basic research into the antioxidant systems in the zebrafish ... -
Reduced Representation Bisulfite Sequencing of Human Neutrophils Reveals Widespread Inter-Individual Epigenetic Variation
Methylation of DNA molecules is a fundamental mechanism for regulating gene function that is prevalent in all vertebrates. Although, the role of DNA methylation is well recognised in the disease context, the knowledge of ... -
Regulation of Antigen Presenting Cells by Human Papillomavirus Small Extracellular Vesicles
Human Papillomavirus (HPV) causes over 99% of cervical cancer cases in the world, and of these, over 70% of cases can be attributed to high-risk HPV. There are prophylactic vaccines for HPV, that specifically target high-risk ... -
Regulation of human PAX2 in cancer cells by Transforming Growth Factor-beta (TGF-β)
The PAired boX (PAX) family is a group of related genes that are highly conserved throughout evolution and are known to play important roles in mammalian development. So far nine members of the PAX gene family (PAX1-9) ... -
RHDV VLP Mediated Delivery of α-Galactosylceramide for Immunotherapy
The immune system has the potential to detect and destroy tumour cells, however naturally occurring anti-tumour immunity is not always capable of controlling tumour growth. Immunotherapy can harness the anti-tumour function ... -
Role of langerin+ cells in skin pathologies
Langerhans cells (LCs) are epidermal immune cells that express C-type lectin receptor langerin along with a subset of dermal dendritic cells. Langerin+ cells play a pivotal role in skin immunity. Previous research has ... -
RRBS and the Epigenetic Effects of Steroids in ALL
Acute lymphoblastic leukaemia (ALL) is a malignant proliferation of immature lymphocytes, mainly occurring in childhood. The pathogenesis of the disease is characterised by multiple molecular abnormalities, including ... -
Searching for a Functional Variant in a Non-Coding Genomic Region Associated with Serum Urate
Gout was historically known as the king of diseases and disease of kings, reserved for those of wealthy, extravagant lifestyles. Far from being resigned to history books, gout is on the rise worldwide and in New Zealand – ... -
Some aspects of prostatic cytology
Since the publication in 1943 of Papanicolau and Traut’s monograph on vaginal cytology, much attention has been focussed on the cells, both normal and neoplastic, exfoliating from almost every body surface. From the ... -
Targeted Epigenetic Editing Using a dCas9- SunTag Methylation System
DNA methylation is a stable and somatically heritable epigenetic process. It is classically understood as a gene silencing mechanism, whereby hypermethylation of gene promoters is largely associated with transcriptional ... -
Targeted Epigenetic Editing using a dCas9-SunTag Demethylation system
DNA methylation is a stable epigenetic modification, playing a critical role in the regulation of gene expression. Dysregulation of DNA methylation is implicated in the pathogenesis of numerous diseases including cancer. ... -
The Accuracy of Manual Fine Needle Aspiration Cytology in the Evaluation of Thyroid Cancer
Background The most common endocrine malignancy is thyroid carcinoma. Thyroid carcinoma constitutes for 0.5% of all cancer deaths. In New Zealand, thyroid carcinoma is less than 1% of all cancer registrations. In New ... -
The Alternative Lengthening of Telomeres Mechanism in Mesenchymal-derived Malignancies: A prognostic tool for Uterine Leiomyosarcoma and STUMP
Uterine smooth muscle tumours of uncertain malignant potential (STUMP) are diagnostically and clinically challenging. A mean to distinguish benign STUMP (leiomyoma) from malignant STUMP (leiomyosarcoma) is required. Chronic ... -
The Cytotoxicity and Action of Curcumin Derivatives against Fn14+ Triple Negative Breast Cancer through repression of NF-κB p65
Triple negative breast cancer (TNBC) is an aggressive subtype of the disease which lacks options for targeted systemic therapies due to a lack of actionable clinical targets. Molecular analysis has revealed that Fn14, a ... -
The Expression of a p53 Isoform Δ133p53, in the Cell Cycle
Overview: p53 is a principal tumour suppressor protein that regulates the cell cycle. By doing so, p53 prevents damaged cells from undergoing DNA replication and cell division by activating pathways involved in DNA repair, ... -
The mouse mutant ∆122p53, a model of the ∆133p53 isoform, promotes migration and metastasis
The tumour suppressor gene p53 is the master sensor and regulator of the response to cell stress. Upon DNA damage, p53 can induce various outcomes including apoptosis, cell cycle arrest, senescence, and DNA repair in order ... -
The presence of ∆133p53 and ∆40p53 in metastatic brain tumours: evidence for further enquiries
Metastatic brain tumours are becoming more prevalent as individuals with primary cancers receive improved treatment and live longer. These brain tumours are difficult to treat and are often left undiagnosed. This study ... -
TP53 in renal vasculitis
Overview: Vasculitis is an autoimmune disease characterised by the swelling and inflammation of blood vessels. Renal vasculitis is a rare, yet severe disease characterised by the inflammation of glomeruli and affiliated ... -
Transcriptional regulation of the Runx1 gene
Runx1 is crucial for blood cell development and is one of the genes most frequently translocated or mutated in leukaemia, thereby contributing to disease pathogenesis. Runx1 is transcribed from two promoters, P1 and P2, ... -
Two Heads Are Better Than One: The Combination of Dendritic Cells & B Cells Yields An Improved T Cell Response Over Dendritic Cells Alone When Presenting Tumour Lysate Antigens
BACKGROUND The best APC for tumour immunotherapy is yet to be defined. The dendritic cell (DC) is well established as the key professional antigen-presenting cell (APC) for priming naïve T cells against tumours and for ...