Browsing Pathology collection - Dunedin by Title
Now showing items 65-79 of 79
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Searching for a Functional Variant in a Non-Coding Genomic Region Associated with Serum Urate
Gout was historically known as the king of diseases and disease of kings, reserved for those of wealthy, extravagant lifestyles. Far from being resigned to history books, gout is on the rise worldwide and in New Zealand – ... -
Some aspects of prostatic cytology
Since the publication in 1943 of Papanicolau and Traut’s monograph on vaginal cytology, much attention has been focussed on the cells, both normal and neoplastic, exfoliating from almost every body surface. From the ... -
Targeted Epigenetic Editing Using a dCas9- SunTag Methylation System
DNA methylation is a stable and somatically heritable epigenetic process. It is classically understood as a gene silencing mechanism, whereby hypermethylation of gene promoters is largely associated with transcriptional ... -
Targeted Epigenetic Editing using a dCas9-SunTag Demethylation system
DNA methylation is a stable epigenetic modification, playing a critical role in the regulation of gene expression. Dysregulation of DNA methylation is implicated in the pathogenesis of numerous diseases including cancer. ... -
The Accuracy of Manual Fine Needle Aspiration Cytology in the Evaluation of Thyroid Cancer
Background The most common endocrine malignancy is thyroid carcinoma. Thyroid carcinoma constitutes for 0.5% of all cancer deaths. In New Zealand, thyroid carcinoma is less than 1% of all cancer registrations. In New ... -
The Alternative Lengthening of Telomeres Mechanism in Mesenchymal-derived Malignancies: A prognostic tool for Uterine Leiomyosarcoma and STUMP
Uterine smooth muscle tumours of uncertain malignant potential (STUMP) are diagnostically and clinically challenging. A mean to distinguish benign STUMP (leiomyoma) from malignant STUMP (leiomyosarcoma) is required. Chronic ... -
The Cytotoxicity and Action of Curcumin Derivatives against Fn14+ Triple Negative Breast Cancer through repression of NF-κB p65
Triple negative breast cancer (TNBC) is an aggressive subtype of the disease which lacks options for targeted systemic therapies due to a lack of actionable clinical targets. Molecular analysis has revealed that Fn14, a ... -
The Expression of a p53 Isoform Δ133p53, in the Cell Cycle
Overview: p53 is a principal tumour suppressor protein that regulates the cell cycle. By doing so, p53 prevents damaged cells from undergoing DNA replication and cell division by activating pathways involved in DNA repair, ... -
The mouse mutant ∆122p53, a model of the ∆133p53 isoform, promotes migration and metastasis
The tumour suppressor gene p53 is the master sensor and regulator of the response to cell stress. Upon DNA damage, p53 can induce various outcomes including apoptosis, cell cycle arrest, senescence, and DNA repair in order ... -
The presence of ∆133p53 and ∆40p53 in metastatic brain tumours: evidence for further enquiries
Metastatic brain tumours are becoming more prevalent as individuals with primary cancers receive improved treatment and live longer. These brain tumours are difficult to treat and are often left undiagnosed. This study ... -
TP53 in renal vasculitis
Overview: Vasculitis is an autoimmune disease characterised by the swelling and inflammation of blood vessels. Renal vasculitis is a rare, yet severe disease characterised by the inflammation of glomeruli and affiliated ... -
Transcriptional regulation of the Runx1 gene
Runx1 is crucial for blood cell development and is one of the genes most frequently translocated or mutated in leukaemia, thereby contributing to disease pathogenesis. Runx1 is transcribed from two promoters, P1 and P2, ... -
Two Heads Are Better Than One: The Combination of Dendritic Cells & B Cells Yields An Improved T Cell Response Over Dendritic Cells Alone When Presenting Tumour Lysate Antigens
BACKGROUND The best APC for tumour immunotherapy is yet to be defined. The dendritic cell (DC) is well established as the key professional antigen-presenting cell (APC) for priming naïve T cells against tumours and for ... -
Understanding the Cellular Consequences of Meier-Gorlin Syndrome
Meier-Gorlin syndrome (MGS) is a rare autosomal recessive disorder characterised by short stature, microtia and patella aplasia/hypoplasia. Genetic variants, which cause MGS, have previously been found in genes involved ... -
YB-1 oncoprotein in cancer and drug resistance
Y-box-binding protein 1 (YB-1) is a biomarker that is predictive of poor prognosis in cancer. Various molecular functions of YB-1 in cancer have been proposed, including the transcriptional regulation of gene expression. ...