Browsing Pathology collection - Dunedin by Date Published
Now showing items 1-20 of 66
-
HPV 16 E6/E7 expressing microparticles alter functional phenotype of Langerhans cell-like cells
High-risk human papillomavirus (HPV) infections can lead to the development of cervical cancer, the fourth most common cancer in women worldwide. High-risk HPV type 16 (HPV16) is responsible for over 50% of cervical cancers ... -
Cohesin and Regulation of Gene Expression During Zebrafish Development
Made up of four subunits, Structural Maintenance of Chromosomes (SMC) proteins, the SMC1 and SMC3 subunits, Rad21 and stromalin antigens (SA1/2), the ring- shaped protein cohesin is an essential part of both the mitotic ... -
Investigation of Several Compounds for the Treatment of Autosomal Dominant Polycystic Kidney Disease
Polycystic kidney disease (PKD) is a leading cause of kidney failure, and one of the most prominent rare hereditary diseases in New Zealand, as well as globally. The autosomal dominant form of this disease (ADPKD) has a ... -
Genome-Wide DNA Methylation in Polycystic Kidney Disease
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a heritable renal disease that causes the enlargement of kidneys due to the bilateral development of fluid-filled cysts. This results in end-stage kidney disease in ... -
Human papillomavirus gene expression in the placenta and its prevalence in an assisted reproduction cohort
Overview: Human papillomavirus (HPV) is well known as the leading cause of cervical cancer worldwide. Whether HPV also contributes to other adverse effects such as those associated with pregnancy is unclear. Higher incidences ... -
Investigation into the relative location of filamin B and YB-1 in cell cycle progression
The cell cycle is a fundamental process in development and the maintenance of homeostasis. Various proteins regulate the cell cycle, such as Y-box binding protein -1 (YB-1). YB-1 transcriptionally regulates cell cycle ... -
Characterising the Functional and Molecular Determinants for Organ Selective Metastasis in Triple Negative Breast Cancer
Triple-negative breast cancer (TNBC) accounts for 10-20% of primary invasive breast cancer diagnoses, globally. With a higher risk of developing visceral and brain metastasis than other breast cancer subtypes, and limited ... -
TP53 in renal vasculitis
Overview: Vasculitis is an autoimmune disease characterised by the swelling and inflammation of blood vessels. Renal vasculitis is a rare, yet severe disease characterised by the inflammation of glomeruli and affiliated ... -
The Expression of a p53 Isoform Δ133p53, in the Cell Cycle
Overview: p53 is a principal tumour suppressor protein that regulates the cell cycle. By doing so, p53 prevents damaged cells from undergoing DNA replication and cell division by activating pathways involved in DNA repair, ... -
Targeted Epigenetic Editing using a dCas9-SunTag Demethylation system
DNA methylation is a stable epigenetic modification, playing a critical role in the regulation of gene expression. Dysregulation of DNA methylation is implicated in the pathogenesis of numerous diseases including cancer. ... -
Regulation of Antigen Presenting Cells by Human Papillomavirus Small Extracellular Vesicles
Human Papillomavirus (HPV) causes over 99% of cervical cancer cases in the world, and of these, over 70% of cases can be attributed to high-risk HPV. There are prophylactic vaccines for HPV, that specifically target high-risk ... -
Identification of synthetic lethal compounds targeting cancers with cohesin mutations
The cohesin complex, comprising four core subunits, RAD21, SMC3, SMC1A, and STAG1/2, is important for the regulation of many biological processes, including sister chromatid cohesion, regulation of gene expression, chromatin ... -
HPV regulation of immunity in persistence and regression
High-risk human papillomavirus (HPV) infection leads to the development of several human cancers that cause significant morbidity and mortality worldwide. Cervical cancer is the most prevalent type of HPV-caused cancers ... -
Peroxiredoxin expression and redox state in human cancers
Peroxiredoxins (Prxs) are a class of ubiquitous peroxidases that degrade hydrogen peroxide. They are found in almost all compartments of the cell: Prxs 1 and 2 in the cytosol, and Prx 3 in the mitochondria. Their role in ... -
Molecular Analysis of Triple Negative Breast cancer
Triple negative breast cancer (TNBC) is a heterogeneous and aggressive subtype making up 10-20% of newly diagnosed invasive breast cancers and currently has no targeted agents approved for systemic therapy. However up to ... -
YB-1 oncoprotein in cancer and drug resistance
Y-box-binding protein 1 (YB-1) is a biomarker that is predictive of poor prognosis in cancer. Various molecular functions of YB-1 in cancer have been proposed, including the transcriptional regulation of gene expression. ... -
Cohesin and CTCF in early zebrafish embryogenesis
Early embryonic development in metazoans is characterised by extensive changes in gene expression and chromatin remodelling at all levels. In most metazoans, zygotic genomes are transcriptionally ... -
Genome-wide DNA Methylation and Gene Expression Analysis of Non-invasive and Invasive Melanoma Cell Lines
Melanoma is a serious form of skin cancer derived from the pigment producing cells called melanocytes. New Zealand has the highest rate of melanoma in the world with as high as 50 cases of melanoma per 100,000 people, ... -
Exploiting the Childhood Acute Lymphoblastic Leukaemia DNA Methylation Profile to Detect a Novel Population of Fetal Lymphocytes
Introduction: Childhood acute lymphoblastic leukaemia (ALL) is a disease that originates before birth and results from the proliferation of neoplastic lymphoid precursor cells in the bone marrow. In the majority of cases ... -
Methylated Circulating Tumour DNA in Myeloma
Myeloma is an incurable malignancy of plasma cells in the bone marrow. Improvements in myeloma treatment have highlighted the need for more sensitive non-invasive measures of residual disease. Circulating tumour DNA in the ...