Browsing Pathology collection - Dunedin by Date Published
Now showing items 1-20 of 78
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Development of zebrafish models for leukaemia
Throughout development, numerous binary cell fate decisions are made where cells activate competing transcriptional networks and subsequently upregulate one network over others based on extrinsic cues. Cell fate decisions ... -
Modeling RECQL4 developmental syndromes in Xenopus laevis using CRISPR/Cas9
There are a number of human genetic conditions of abnormal skeletal development associated with disrupted DNA replication, with several linked to mutations in RECQL4. While several mouse models targeting Recql4 have been ... -
Investigating the Influence of Metabolic Syndrome on Cancer Immunotherapy
Cancer is a significant cause of morbidity in New Zealand, with breast and colorectal cancers being amongst the most commonly diagnosed. Therapeutic research has moved into immunotherapies, harnessing the immune system to ... -
Mechanisms of DNA demethylation
While every cell in an organism is genetically identical, there are marked phenotypic differences between tissues and organs that are controlled by epigenetic modifications. These epigenetic modifications provide an important ... -
Examining the role of cohesin subunit Rad21 in malignancy and development
The cohesin complex is essential for cell survival, owing to its well-established roles in cell division, DNA repair and gene expression. Malignancy and developmental disorders termed the cohesinopathies can result when ... -
In situ expression of biomarkers in placenta in the context of hypertensive disorders of pregnancy
Overview: Hypertensive disorders in pregnancy (HDP), of which the most common is pre- eclampsia (PE), are a leading cause of maternal and foetal morbidity and mortality worldwide. Despite extensive research, no clear cause ... -
Investigating the Direct Role of Promoter DNA Methylation in Gene Expression using a Targeted TET1CD-dCas9 Demethylase Tool
DNA hypermethylation of gene promoter regions has long been associated with transcriptional repression. Furthermore, the establishment of dense promoter methylation within tumour- suppressor genes has been widely-characterised ... -
DNA methylation in pre-eclampsia: methodologies and analytics
The placenta is a heterogeneous and multifunctional organ that grows and adapts according to increasing and fluctuating fetal demands in the intrauterine environment. As expected, the placenta plays a major role in pregnancy ... -
Targeted Epigenetic Editing Using a dCas9- SunTag Methylation System
DNA methylation is a stable and somatically heritable epigenetic process. It is classically understood as a gene silencing mechanism, whereby hypermethylation of gene promoters is largely associated with transcriptional ... -
Profiling the pregnancy-specific glycoprotein genes in pre-eclampsia.
Background: Pre-eclampsia (PE) is a hypertensive disorder of pregnancy which is characterised by reduced placental cell invasion into the maternal arteries. Lack of invasion causes insufficient transformation of arteries ... -
Constitutive PD-L1 expression in melanoma
Treatment of melanoma based on targeted therapy and immunotherapy has dramatically advanced over the past decade. Advances in targeted therapy have been based on inhibition of the MAPK pathway while for immunotherapy, ... -
Understanding the Cellular Consequences of Meier-Gorlin Syndrome
Meier-Gorlin syndrome (MGS) is a rare autosomal recessive disorder characterised by short stature, microtia and patella aplasia/hypoplasia. Genetic variants, which cause MGS, have previously been found in genes involved ... -
Investigation of Several Compounds for the Treatment of Autosomal Dominant Polycystic Kidney Disease
Polycystic kidney disease (PKD) is a leading cause of kidney failure, and one of the most prominent rare hereditary diseases in New Zealand, as well as globally. The autosomal dominant form of this disease (ADPKD) has a ... -
Genome-Wide DNA Methylation in Polycystic Kidney Disease
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a heritable renal disease that causes the enlargement of kidneys due to the bilateral development of fluid-filled cysts. This results in end-stage kidney disease in ... -
Cohesin and Regulation of Gene Expression During Zebrafish Development
Made up of four subunits, Structural Maintenance of Chromosomes (SMC) proteins, the SMC1 and SMC3 subunits, Rad21 and stromalin antigens (SA1/2), the ring- shaped protein cohesin is an essential part of both the mitotic ... -
Regulation of Antigen Presenting Cells by Human Papillomavirus Small Extracellular Vesicles
Human Papillomavirus (HPV) causes over 99% of cervical cancer cases in the world, and of these, over 70% of cases can be attributed to high-risk HPV. There are prophylactic vaccines for HPV, that specifically target high-risk ... -
Investigation into the relative location of filamin B and YB-1 in cell cycle progression
The cell cycle is a fundamental process in development and the maintenance of homeostasis. Various proteins regulate the cell cycle, such as Y-box binding protein -1 (YB-1). YB-1 transcriptionally regulates cell cycle ... -
Characterising the Functional and Molecular Determinants for Organ Selective Metastasis in Triple Negative Breast Cancer
Triple-negative breast cancer (TNBC) accounts for 10-20% of primary invasive breast cancer diagnoses, globally. With a higher risk of developing visceral and brain metastasis than other breast cancer subtypes, and limited ... -
Human papillomavirus gene expression in the placenta and its prevalence in an assisted reproduction cohort
Overview: Human papillomavirus (HPV) is well known as the leading cause of cervical cancer worldwide. Whether HPV also contributes to other adverse effects such as those associated with pregnancy is unclear. Higher incidences ... -
Identification of synthetic lethal compounds targeting cancers with cohesin mutations
The cohesin complex, comprising four core subunits, RAD21, SMC3, SMC1A, and STAG1/2, is important for the regulation of many biological processes, including sister chromatid cohesion, regulation of gene expression, chromatin ...