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Transcriptional regulation of the Runx1 gene
Runx1 is crucial for blood cell development and is one of the genes most frequently translocated or mutated in leukaemia, thereby contributing to disease pathogenesis. Runx1 is transcribed from two promoters, P1 and P2, ...
Chemically induced DNA hemimethylation and active demethylation
The inheritance of epigenetic signals involves DNA methylation. DNA methylation patterns are inherited through cell generations by the action of DNA methyltransferases (DNMTs). During DNA replication DNMTs recognise ...
Mutant p53 and pro-inflammatory gene expression in colorectal cancer cells
p53 gene is the most commonly mutated gene in cancer, and in many malignancies a loss of p53 promotes cancer progression. However recent evidence has shown that missense mutations in p53, particularly those that lead to ...
Peripheral lobular necrosis in hepatitis
Foreword: In recent years knowledge of the clinical and pathological features of hepatitis has so increased that the disease has now become the subject of reviews (e.g: Sodeman 1946, Editorial, Ann. Int. Med. 1946, Dible ...
Coupling the Adjuvant CpG Oligonucleotides to RHDV VLP
Immunotherapies have the potential to harness the immune system in order to target and clear cancer cells. One branch of immunotherapeutic research is the development of cancer vaccines. Virus-like particles (VLP) make ...
The Alternative Lengthening of Telomeres Mechanism in Mesenchymal-derived Malignancies: A prognostic tool for Uterine Leiomyosarcoma and STUMP
Uterine smooth muscle tumours of uncertain malignant potential (STUMP) are diagnostically and clinically challenging. A mean to distinguish benign STUMP (leiomyoma) from malignant STUMP (leiomyosarcoma) is required. Chronic ...
Pathogenicity Studies of the Ciliopathy Gene, MKS3, in Zebrafish Embryos
Polycystic kidney disease (PKD) is a genetic disorder that affects between 1 in 400 to in 1000 people worldwide. PKD is a ciliopathy and is characterized by fluid-filled cysts that form in both kidneys, causing significant ...
Regulation of human PAX2 in cancer cells by Transforming Growth Factor-beta (TGF-β)
The PAired boX (PAX) family is a group of related genes that are highly conserved throughout evolution and are known to play important roles in mammalian development. So far nine members of the PAX gene family (PAX1-9) ...
Phenotyping Langerhans cell like cell treated with microparticles from keratinocytes expressing human papilloma viruse16 E7 oncoprotein
Cervical cancer in females is a worldwide health issue. High risk subtype of human papilloma viruses (HPV) are involved as a major risk factor. HPV oncogenes, E7 and E6 which are over-expressed in the host cells and promote ...
Some aspects of prostatic cytology
Since the publication in 1943 of Papanicolau and Traut’s monograph on vaginal cytology, much attention has been focussed on the cells, both normal and neoplastic, exfoliating from almost every body surface.
From the ...