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dc.contributor.advisorRich, Alison
dc.contributor.advisorHuckabee, Maggie-Lee
dc.contributor.advisorMacFadyen, Eithne
dc.contributor.advisorMedlicott, Natalie
dc.contributor.authorApperley, Olivia
dc.date.available2015-11-08T22:06:18Z
dc.date.copyright2015
dc.identifier.citationApperley, O. (2015). Management of Xerostomia Following Radiotherapy: A clinical trial of a novel emulsion for potential use as a saliva substitute (Thesis, Doctor of Clinical Dentistry). University of Otago. Retrieved from http://hdl.handle.net/10523/6052en
dc.identifier.urihttp://hdl.handle.net/10523/6052
dc.description.abstractAim: Researchers have recently developed a novel oily formulation for potential us as a saliva substitute. The aim of this randomised, cross-over study is to compare this new formulation to a currently available saliva substitute and a control of water on measures of mastication, subjective feeling of oral dryness and product acceptability. Methods: Forty participants treated with radiotherapy to the head and neck region and experiencing xerostomia were selected to participate in the trial. Each participant trialled all three products in a randomised order. The effect of each product was measured using the Test of Masticating and Swallowing Solids (TOMASS), the shortened Xerostomia Inventory (SXI) and a questionnaire designed to test the patient acceptability of each product. Outcome data were gathered in a single session after the first administration of each product to evaluate immediate effects, and after seven days of use to evaluate longer-term effects. Statistical analysis consisted of repeated measures analysis of variance and mixed effect models. Results: There was no effect of any of the three formulations either with immediate or cumulative use on any of the TOMASS measures (p > 0.05). Application of the novel emulsion resulted in a clinically small but significant improvement in SXI score compared to baseline (p<0.01), however application of methylcellulose (p=0.21) and water (p=0.81) resulted in no significant difference compared to baseline values. There was no difference in participant acceptability between the 3 products (p=0.32). Conclusion: The novel oily emulsion shows no clinically significant benefit over two existing products for relief of xerostomia. Indeed, none of the three products demonstrated significant change in patient outcomes.
dc.language.isoen
dc.publisherUniversity of Otago
dc.rightsAll items in OUR Archive are provided for private study and research purposes and are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectSaliva substitute
dc.subjectArtificial saliva
dc.subjectMouth moisturiser
dc.subjectXerostomia
dc.subjectRadiotherapy
dc.titleManagement of Xerostomia Following Radiotherapy: A clinical trial of a novel emulsion for potential use as a saliva substitute
dc.typeThesis
dc.date.updated2015-11-06T00:34:39Z
dc.language.rfc3066en
thesis.degree.disciplineDepartment of Oral Diagnostic and Surgical Sciences
thesis.degree.nameDoctor of Clinical Dentistry
thesis.degree.grantorUniversity of Otago
thesis.degree.levelDoctoral
otago.interloanyes
otago.openaccessAbstract Only
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