• The role of the mTOR-Raptor complex in driving hyperuricemia-induced diabetes mellitus 

  Brocherie, Paris Rhiannon

  Elevated serum uric acid (hyperuricemia) when left untreated can lead to a range of pathologies including gout, cancer and type 2 diabetes mellitus (T2DM). It has been shown that after three days of exposure to hyperuricemic ...

• Analysing components of the Torso-activation module: Do they pattern the end-terminal regions of two Hymenopteran insect species, Apis mellifera and Nasonia vitripennis? 

  Tuffery, Jack William

  This project sought to determine if components of the Torso-activation module pattern the embryonic anterior and posterior ends of the honey bee, Apis mellifera, and the parasitoid wasp, Nasonia vitripennis via a patterning ...

• Disarming tissue factor: generating a model tumour antigen 

  Dinh, Thu Nho

  Coagulative abnormalities are a well-recognised feature of malignancy. The risk of developing thrombotic disorders is increased four-fold in cancer patients and more than six-fold higher in those receiving chemotherapy. ...

• Investigating Teixobactin Tolerance in Enterococcus faecalis 

  Todd Rose, Francesca Olivia

  The rapid rise of antimicrobial resistance (AMR) poses a global threat to human health. Key to combating antimicrobial resistance will be to increase our understanding of how resistance develops. Conventional antimicrobial ...

• The presence of ∆133p53 and ∆40p53 in metastatic brain tumours: evidence for further enquiries 

  Tahmeedzaman, Quazi

  Metastatic brain tumours are becoming more prevalent as individuals with primary cancers receive improved treatment and live longer. These brain tumours are difficult to treat and are often left undiagnosed. This study ...

• Development of a local protocol and method to measure Beta-Cell Function in individuals with Pre-diabetes and Type 2 Diabetes 

  Kanaan, Rami

  Type 2 diabetes mellitus (T2DM) is long-term metabolic disorder characterised by high blood glucose (BG), insulin resistance and poor insulin secretion. T2DM is preceded by pre-diabetes characterised by altered glucose ...

• Targeted Enrichment and Nanopore Sequencing of RNA Transcripts from Breast Cancer Risk Genes 

  Chang, Jessie Jie-Youen

  Aberrant alternative splicing of hereditary breast and ovarian cancer genes has been associated with an increased susceptibility for breast and/or ovarian cancer. However, studying the effects of gene variants on splicing ...

• Characterisation of a phase-variable restriction-modification system in Enterococcus faecalis 

  Campbell, Isobella

  The gastrointestinal colonizer Enterococcus faecalis is an opportunistic, multi-drug resistant pathogen and a leading cause of nosocomial infections. Vancomycin- resistant enterococci (VRE) are of particular concern and ...

• Aspirin’s role in preventing E-cadherin cleavage by the carcinogenic Bacteroides fragilis toxin 

  Swan, James Raymond

  Carriage of enterotoxigenic Bacteroides fragilis (ETBF) in the colonic mucosa is associated with increased risk of pre-cancerous lesions. Antibiotics will not selectively eradicate these bacteria, but toxin-mediated host ...

• Identification of AH1-specific T cells in a mouse model of colorectal cancer 

  Harte, Jessica Elise

  Colorectal cancer (CRC) causes approximately 1.4 million new cases of disease and 700,000 deaths worldwide annually. To overcome limitations of studying CRC in humans, mouse models are used to test therapeutics such as ...

• Intracellular redox changes during TNFα-mediated necroptosis 

  Heath, Sarah

  Necroptosis is a form of regulated cell death triggered by a variety of factors associated with infection and inflammation. It is distinct from the well-characterised cell death processes of apoptosis and necrosis, sharing ...

• CNVs and familial breast and ovarian cancer 

  Chai, Isabelle

  BRCA1 pathogenic variant carriers experience a high risk of developing breast and ovarian cancer, however, differences in risk vary greatly between individuals. The advent of genetic testing has presented an increasing ...

• Identifying the role of connexin 43 in transport of microRNAs 

  Mamgain, Asha

  Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Present treatments for CVD rely heavily on surgical interventions and drug therapies that relieve symptoms rather than cure the disease. Therefore, ...

• The Impact of Epithelial Sodium Channel on Breast Cancer Cell Migration 

  McQueen, Sarah Ruth Anne

  Breast cancer is the most common cancer in New Zealand women, with the majority of breast cancer deaths being due to metastasis. This highlights the importance of identifying regulators and, thus, potential therapeutic ...

• Sodium and Uric Acid as Modulators of Vascular Endothelial ENaC 

  Twyman, Claire

  Hypertension, defined as a chronically high blood pressure, is a significant risk factor for heart attacks and strokes. Despite hypertension affecting 28% of individuals over the age of 20 years old, little is known about ...

• Modulation of Lineage Development in the Colonic Epithelium 

  O'Hagan, Felix

  Despite being exposed to microbial and food antigens, the human gastrointestinal tract does not exist in a state of inflammation. This homeostasis is critically dependent on the colonic epithelial barrier, which when ...

• Investigating the Effects of Chronic Low-Grade Inflammation on Cancer Immunotherapy 

  Evans, Meghan

  Cancer is the leading cause of death in New Zealand and is responsible for approximately one third of all deaths. Due to various factors, including unhealthy life style choices and an aging population, the number of new ...

• Balancing Safety and Developmental Potency: Assessing the Effect of Antioxidants and TET on Genomic Imprinting Stability. 

  Dunnet, Michael John

  Developmental potency represents the ability of undifferentiated cells to undergo transformation into differentiated cells, with specialised functions. The inner cell mass (ICM) of a blastocyst represents the most ...

• MR1 surface expression on primary blood cells and their role in mucosal associated invariant T (MAIT) cell activation 

  Roman, Tabatha

  Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that bridge the innate and adaptive immune systems to provide rapid effector responses against a broad range of bacteria. MAIT cells are characterised ...

• Mapping post-stroke brain activation patterns: How do they change over time? 

  Basnayake, Nuvindi

  Stroke is a leading cause of death and long-term disability worldwide. Despite decades of research on neuroprotection, only few therapies are currently available to minimise the extent of infarction. As a result, researchers ...

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