• The functional role of cardiac non-neuronal cholinergic system in the diabetic heart 

  Saw, Eng Leng

  In type-2 diabetes mellitus (T2DM), insulin resistance and metabolic derangements reduce glucose transporter-4 (GLUT-4) expression to decrease glucose uptake, and hence the glucose oxidation in the diabetic heart. Further, ...

• Nicotine with speed: The role of more rapid-delivery of nicotine combined with slow transdermal delivery of nicotine for smoking cessation 

  Caldwell, Brent Ower

  Background: Smoking is the biggest cause of preventable death in industrialised countries. Quit rates after use of current Nicotine Replacement Therapy (NRT) are low. Animal studies suggest nicotine is more rewarding ...

• Self-management outcome measures for children with inflammatory bowel disease 

  Hurley, Angharad

  Paediatric Inflammatory Bowel Disease (IBD) can significantly affect a child’s physical and psychological well-being, and the incidence is increasing globally. An emerging focus of paediatric IBD care that has the potential ...

• Military Medicines: ANZAC Military Pharmacy, 1914-1918 

  Doughty, Lee Ellen

  Military pharmacy is a niche subset of the wider pharmacy profession. As a small component of the armed forces, the role encompasses unique military requirements beyond usual pharmacy practice. This thesis analyses the ...

• The antiviral mechanism and viral antagonism of host histone deacetylase 4 in influenza A virus infection 

  Galvin, Henry David

  Influenza virus continues to be an important global pathogen which poses serious health and economic challenges. Influenza virus causes regular seasonal epidemics, intermittent and unpredictable pandemics and deadly zoonotic ...

• Mucosal associated invariant T cells: mechanisms of bacterial control in humans 

  Lamichhane, Rajesh

  Mucosal associated invariant T (MAIT) cells are an unconventional T cell subset that are abundant in humans in blood, liver, and mucosal tissues. MAIT cells express a semi-invariant T cell receptor (TCR) (Vα7.2-Jα12/20/33) ...

• Regulation of DEPTOR Ubiquitination by Uric Acid in the Pancreatic β-Cell 

  Cain, Ethan Campbell Jordan

  As rates of non-communicable disease such as diabetes mellitus raise the questions regarding how these diseases arise becomes more pertinent. One of the major causes of these types of disease is the effects of the modern ...

• Role of cancer associated adipocytes (CAA) and tumour associated collagen structures (TACS) in breast cancer cell invasion and metastasis 

  Puri, Mohini

  In post-menopausal breast cancer, obesity is related to invasive tumours that are resistant to chemotherapy and have a poor outcome. Recent research has revealed that adipocytes co-cultured with breast cancer cells ...

• The influence of aspects of the biophysical environment on ovarian cancer cell behaviour 

  Sarwar, Mian Makhdoom

  It has been increasingly acknowledged that the extracellular physical environment plays a vital role in cancer development and progression. However, the precise mechanisms of how the biophysical extracellular environment ...

• Scoping for RNA biomarkers in colorectal cancer 

  Morley-Bunker, Arthur Edward

  Colorectal cancer (CRC) is a major health problem worldwide and a significant issue in New Zealand. Treatment for patients with CRC is morbid and costly, involving a combination of surgery, radiotherapy and chemotherapy. ...

• What protects against pre-diabetes progressing to diabetes? Observational study of integrated health and social data 

  Teng, Andrea; Blakely, Tony; Scott, Nina; Jansen, Rawiri; Masters-Awatere, Bridgette; Krebs, Jeremy; Oetzel, John

  Aims To examine the incidence of type 2 diabetes in people with newly diagnosed prediabetes and the factors that protect against this progression. Methods The study population was 14,043 adults with pre-diabetes ...

• THE NEW ZEALAND UNDERGRADUATE OBSTETRICS AND GYNAECOLOGY CURRICULUM 

  Paterson, Helen; Stone, Peter

  Aims of New Zealand O&G curriculum collaboration To ensure and continue to improve quality and consistency of learning outcomes in Obstetrics and Gynaecology on a national basis To inform the Medical Council of New ...

• The anti-influenza viral mechanism and viral antagonism of host histone deacetylase 6 

  Hussain, Mazhar

  Influenza virus is a causative agent of respiratory illness called "flu" and is a prototypic member of Orthomyxoviridae family. Influenza viruses are enveloped, negative-sense single stranded RNA viruses with a segmented ...

• The development of methods for improving accuracy and validity of musculoskeletal modelling of the lower limb 

  Carman, Allan Bruce

  The aim of present study was to address limitations in model design, anatomical data, and implementation of muscle force-length and force velocity relationships for the purpose of improving accuracy and validity of ...

• Advanced Meta-analysis in Surgical Research 

  Amer, Mohammad Ashraf Rashad

  The continuous development and refinement of techniques is a key attribute of the discipline of surgery. Robust evidence derived from randomised clinical trials and subsequent synthesis using meta-analysis methods is ...

• Oxidant generation by Streptococcus pneumoniae associated with neutrophil extracellular traps 

  Kaldor, Christopher David

  Streptococcus pneumoniae are a common human pathogen, and the leading cause of community-acquired pneumonia world-wide. They have been shown to survive neutrophil extracellular traps (NETs), which are chromatin structures ...

• 'You can't hate yourself thin' Obesity recovery and self-compassion 

  Ottley, Katrin

  Obesity is a major public health concern in the developed, and increasingly in the developing world. One theory aimed at understanding the aetiology of obesity proposes that highly palatable foods may have addictive ...

• DNA methylation memory: Understanding epigenetic reprogramming in vertebrates 

  Ortega Recalde, Oscar Javier

  DNA methylation is an epigenetic mark critical for vertebrate development and is associated with numerous cellular and organismal processes including X-chromosome inactivation, genomic imprinting, and regulation of gene ...

• Defining the role of respiratory oxidase function in mycobacteria 

  Williams, Zoe Corin

  Members of the Mycobacterium genus are well known for their energetic flexibility, a trait which they exploit to grow and survive under a wide range of oxygen tensions, including hypoxia. Contributing to this flexibility ...

• Identification of synthetic lethal compounds targeting cancers with cohesin mutations 

  Chin, Chue Vin

  The cohesin complex, comprising four core subunits, RAD21, SMC3, SMC1A, and STAG1/2, is important for the regulation of many biological processes, including sister chromatid cohesion, regulation of gene expression, chromatin ...

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