• Endothelial nitric oxide synthase deficiency – implications for Alzheimer’s disease 

  Hariharan, Ashwini

  Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory loss and neuropathological hallmarks of amyloid- (A) plaques and neurofibrillary tangles, with aging as a major risk factor. ...

• Characterising T cell responses to chitosan hydrogel vaccines in an orthotopic mouse model of colorectal cancer 

  Gaskarth, Douglas

  Anti-tumour T cell responses have a critical role in determining patient outcome in colorectal cancer (CRC). However, the generation of favourable immune responses in humans is poorly understood. Mouse models of CRC often ...

• An integrative approach to understanding antimicrobial resistance in New Zealand 

  Mitchell, Sarah

  Antimicrobial resistance (AMR) occurs when micro-organisms (including bacteria, viruses, fungi and parasites) survive exposure to a medicine that would usually kill them or halt their growth. This is a natural phenomenon ...

• Sex, drugs, smokes and booze: What's driving teen trends? Describing and explaining trends in adolescent sexual behaviour, cannabis use, smoking and alcohol use in the early 21st century 

  Ball, Jude

  Today’s adolescents are far less likely to smoke, drink, use drugs or be sexually active than their 1990s counterparts. My doctoral project set out to describe and explain trends in adolescent risk behaviours in the early ...

• Development of a viral chemokine binding protein as a diagnostic tool for chemokine detection. 

  Burgess, Rory

  Chemokines serve an integral role in the inflammatory response, specifically through the development of a chemotactic gradient which directs the trafficking of inflammatory leukocytes to the site of tissue damage or ...

• Non-Lamellar Liquid Crystalline Nanoparticles for Targeted Delivery of Endogenous Lipids to the Brain 

  Mohammad, Younus

  Purpose: Bioactive endogenous lipids such as N-acylethanolamines (NAEs) and alkylglycerols have shown therapeutic potential in various neurological diseases and targeted brain drug delivery, respectively. However, their ...

• Dentists’ knowledge and experiences of treating patients with Head and Neck Cancer. 

  Dixon, Hayley Gwenda

  Background In Australasia, Head and Neck Cancer (HNC) is more common and survivable than ever before. As a result, the population prevalence of HNC patients (including HNC survivors) in our communities is ever-increasing. ...

• The effect of removing PsbJ in Synechocystis sp. PCC 6803 mutants that lack the extrinsic proteins of Photosystem II 

  Choo, Peixi

  Photosystem II (PS II) is the light-driven water-plastoquinone oxidoreductase of photosynthesis. PS II consists of 20 protein subunits including four core complexes forming the reaction centre, 13 additional low-molecular-weight ...

• Investigation of ubiquitin transfer by RING E3 ligases RNF121 and RNF114 

  Nguyen, Khanh Hong Truc

  Ubiquitylation is a post-translational modification that modulates protein turnover, function and localisation. The attachment of ubiquitin is achieved by a sophisticated enzyme cascade. Specificity is provided by E3 ...

• Transcriptional effects of mood stabiliser drugs in a serotonergic cell line 

  Sinha, Priyanka

  Sodium valproate (VPA) and lithium are drugs of different chemical classes that are widely prescribed in the treatment of bipolar disorder (BD). Molecular and pharmacological studies have revealed some relevant properties ...

• Is sarcopenia a neurodegenerative disease? 

  Gillon, Ashley

  Sarcopenia is a major contributor to the loss of independence and deteriorating quality of life in elderly individuals. It is marked by declining skeletal muscle mass and strength beyond the age of 65. Sarcopenia places ...

• The regulation of ascorbate accumulation in plants 

  Chisnall, Matthew Allan Weeber

  Ascorbate (Vitamin C) is vital to human health. We are unable to synthesise ascorbate and attain the majority of ascorbate from plants. Ascorbate accumulation is a complex, regulated and environmentally responsive trait ...

• Scaling of clearance by body size and composition 

  Sinha, Jaydeep

  Dose scaling is a critical component of dose individualisation that helps ensure that the required amount of drug exposure is achieved in each and every patient. This is typically achieved by scaling the pharmacokinetic ...

• “TELL SOMEONE WHO CARES” – PARTICIPATORY ACTION RESEARCH OF MOTIVATION AND WORKPLACE ENGAGEMENT AMONG CAREGIVERS IN AGED RESIDENTIAL CARE, NEW ZEALAND 

  Prentice, Jennifer Joan

  Ageing is an inevitable part of the human life cycle. Life for older adults can be active and independent, and often until late older age, but for some people older age means living in an aged residential care (ARC) facility. ...

• Characterisation of a new role for the UBA domain in ubiquitin chain synthesis by Ube2K 

  Doorman, Josiah

  Ubiquitylation is a post-translational modification in which the protein Ubiquitin (Ub) is attached to other proteins, dictating their fate. Ubiquitylation requires the action of three groups of enzymes, Ub activating (E1) ...

• The Effect of Raw and Processed Bovine Milk Consumption on Immune Responses in Allergy and Health 

  Shirley, Simon

  A large body of epidemiological evidence shows that children who consume raw bovine milk in early life have reduced incidence of allergies and asthma in later life; while consumption of heat-treated, or processed milk, ...

• Effects of vasoactive agents on tumour blood flow and cytotoxic drug uptake. 

  Robinson, Bridget Anne

  Response of tumours to chemotherapy is limited by resistance, inherent or developing during treatment, causes of which include impaired drug delivery and changes in cellular drug transport. Although high-dose intravenous ...

• The Health Impacts of Increasing Social Inequality in Late Prehistoric Northeast Thailand 

  Ward, Stacey Maree

  Evidence for increasing social inequality and a concurrent health deterioration has been observed in Iron Age (420BCE-500CE) northeast Thailand. Inequality is commonly considered to be represented by variations in quantities ...

• Cold and Crowded - The Early Childhood Education Environments Study 

  Bedford, Mike

  Background In recent decades New Zealand has seen a growth in the use of childcare as a weekday living environment for children under five years old, with an increasing proportion of children attending, and children ...

• Clinical and Surgical Anatomy of the Ligament of the Head of Femur 

  Perumal, Vivekanandan

  The ligament of the head of femur (LHF), or ligamentum teres, is an intra-articular ligament of the hip joint, running between the transverse acetabular ligament (TAL) of the hip and the fovea capitis femoris (FCF) on the ...

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