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Division of Health Sciences Departments

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The Division of Health Sciences will provide New Zealand society and other communities with a highly qualified workforce in the health professions. The Division will promote health and health care through basic and applied research and academic and professional leadership. This will be achieved through research-based undergraduate, postgraduate and professional academic programmes of international standard in the health sciences and related sciences.

Sub-communities within Division of Health Sciences Departments

Dunedin School of Medicine [403]
Faculty of Dentistry [156]
School of Biomedical Sciences [619]
University of Otago, Christchurch School of Medicine and Health Sciences [189]

Christchurch School of Medicine and Health Sciences
University of Otago, Wellington [191]

Wellington School of Medicine and Health Sciences

Collections in Division of Health Sciences Departments

Recent Deposits

The impact of high and low-intensity transcranial magnetic stimulation on measures of cortical excitability

Sykes, Matthew John (Thesis, Doctor of Philosophy, 2018)

In recent decades, transcranial magnetic stimulation (TMS) has emerged as one of the most promising techniques for clinical therapies. It has been proposed for use in a wide number of neurophysiological disorders including ...
The dose individualisation of oral anticoagulants

Mohd Saffian, Shamin (Thesis, Doctor of Philosophy, 2018)

Oral anticoagulants are used to treat and prevent blood clots. All anticoagulants carry the risk of bleeding if the systemic exposure is too high, while inadequate exposure will increase the risk of thrombosis. Therefore, ...
Stereological analysis of the normal red nucleus, and the effect of delayed treatment with adult-sourced adipose-derived mesenchymal stem cells on neonatal hypoxic-ischemic brain injury and motor skills, in the rat

Aghoghovwia, Benjamin Emoefe (Thesis, Doctor of Philosophy, 2018)

The red nucleus (RN) was investigated first to provide important data for the transfer of information through the RN and to learn key stereological methods that were then applied to the stem cell study. Six male rats, and ...
Health needs of children in State care

Duncanson, Mavis (Conference or Workshop Item (Poster), Paediatric Society of New Zealand 69th Annual Scientific Meeting, 2017)

Background There are over 5,500 children and young people in the custody of the State in New Zealand. Their complex experiences and life stories have important implications for health services. Research has shown that ...
Investigating Disease Processes in CLN5 and CLN6 Batten Disease

Best, Hannah (Thesis, Doctor of Philosophy, 2017)

The neuronal ceroid lipofuscinoses (NCL, Batten disease) are a heterogeneous group of inherited neurodegenerative disorders, clinically characterised by blindness, myoclonic epilepsy, cerebral atrophy, and progressive ...
A novel central pathway for sympathetic activation in the early stages following an acute myocardial infarction

Roy, Ranjan Kumer (Thesis, Doctor of Philosophy, 2017)

Acute myocardial infarction (MI) initiates an adverse and sustained increase in cardiac sympathetic nerve activity (SNA), which begins as early as 30 min after the infarct, provoking arrhythmias and is a leading factor for ...
PKCε Phosphorylation of RyR2: A Novel Link between Diabetes and Arrhythmia.

Wong, Alexander (Thesis, Bachelor of Biomedical Sciences with Honours, 2017)

Cardiovascular disease (CVD) is the leading cause of death in the world. Arrhythmia is a type of CVD which can be caused by store overload induced calcium (Ca2+) release (SOICR) in cardiomyocytes. SOICR occurs ...
Predisposition to Non Alcoholic Fatty Liver Disease in Preterm Guinea Pigs

Barnes, Heather (Thesis, Bachelor of Biomedical Sciences with Honours, 2017)

Background: Preterm birth accounts for ~10% of all births and is now an established risk factor for the development of metabolic syndrome, a cluster of conditions responsible for significant morbidity and mortality in New ...
Child Poverty Monitor: Technical Report 2017

Duncanson, M; Oben, G; Wicken, A; Morris, S; McGee, M.A.; Simpson, J (Commissioned Report for External Body, 2017)

The Child Poverty Monitor and this Technical Report provide data on a set of indicators that assess aspects of child poverty in New Zealand and their implications for child wellbeing. In it are data on income and non-income ...
Tumour Extracellular Vesicles in Cancer Metastasis & Thrombosis

Muhsin, Morad-Remy (Thesis, Doctor of Philosophy, 2017)

Tumour cells release lipid particles known as extracellular vesicles (EV) that contribute to cancer metastasis, to the immune response, and to thrombosis. There are many types of identified EV, and most live tumour cells ...
ISCOMs and related colloidal particles prepared by the lipid film hydration method for antigen delivery

Demana, Patrick Hulisani (Thesis, Doctor of Philosophy, 2004)

Purposes: The aims of this thesis were to physicochemically investigate the formation of ISCOM matrices and other types of colloidal particles formed in aqueous dispersion as a function of different mass ratios of Quil A, ...
Characterising a large population of langerin+, MHC-II+ cells in mouse skin wounds

Giliam, Megan Elizabeth (Thesis, Master of Science, 2017)

Developing a thorough understanding of wound healing is crucial given the importance of the skin and the many challenges medical professionals face when it is damaged. The immune system is very involved in the healing ...
The patient experience of musculoskeletal imaging: a mixed methods study

Bourke, Sandra (Thesis, Master of Medical Science, 2017)

Introduction: Musculoskeletal (MSK) imaging tests are used for diagnosis and management of arthritis. Although the technical and performance properties of conventional radiography (CR), ultrasound (US), computed ...
Measuring Markers of Immune Response in Patients Treated with Nivolumab (Opdivo®) and Pembrolizumab (Keytruda®)

Butt, Leah (Thesis, Bachelor of Biomedical Sciences with Honours, 2017)

Immune checkpoint inhibitors (ICIs) have drastically improved the clinical outcome for many cancer patients. However, not all patients treated with ICIs show a clinical response and the development of a unique spectrum of ...
Investigating the Site of Innate Lymphoid Cell Division Following BCG Vaccination

Lewis, Claudia (Thesis, Bachelor of Biomedical Sciences with Honours, 2017)

Tuberculosis (TB) is the most deadly infectious disease worldwide, killing 1.4 million people each year. Efforts to control the spread of this disease through antibiotic treatments and a century-old preventative vaccine, ...
Influence of the p53 isoform, delta133p53, on cytoskeletal dynamics during the initiation of migration

Buchanan, Olivia (Thesis, Bachelor of Biomedical Sciences with Honours, 2017)

The well-known tumour suppressor p53 is known to prevent the development of tumours. Recent research has highlighted the importance of an N-truncated isoform, Δ133p53, in the progression of metastatic cancers. This particular ...
Identification of Transporters Involved in Drug-drug Interactions During Gout Treatment in Primary Rat Hepatocytes

Nguyen, Khanh Ho Kim (Thesis, Bachelor of Biomedical Sciences with Honours, 2017)

Gout is one of the most common form of inflammatory arthritis, with hyperuricemia as the major risk factor. Chronic hyperuricemia, or high level of serum uric acid (SUA), can lead to the formation of monosodium urate ...
The effect of the trafficking protein p11 on the epithelial sodium channel

Arora, Nikhil (Thesis, Bachelor of Biomedical Sciences with Honours, 2017)

Regulation of renal sodium (Na+) excretion is crucial for the maintenance of extracellular salt and volume homeostasis and thus for blood pressure control. The epithelial sodium channel (ENaC) is composed of three subunits; ...
Novel grafting materials for sinus floor elevation in the sheep model

Sheftel, Yevgeny (Thesis, Doctor of Clinical Dentistry, 2017)

Introduction: Sinus floor elevation (SFE) may be required for implant placement in the severely resorbed posterior maxilla. Although often successful, autologous bone grafting requires a donor site and may lose substantial ...
Determining the best combination of TLR Agonist and Tumour Peptide for Cancer Vaccination

Gaskarth, Douglas (Thesis, Bachelor of Biomedical Sciences with Honours, 2017)

Immunotherapy has revolutionised the treatment of cancer in recent years; significantly improving patient response and long-term survival. Though many immunotherapies focus on increasing the effector function of immune ...