Browsing Division of Health Sciences Departments by Title
Now showing items 1039-1058 of 4372
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Different modes of heat stress uniformly increase intracranial pressure despite heterogeneous effects on brain perfusion in humans
The brain is the organ most vulnerable to heat stress. This vulnerability manifests as impaired cognition, orthostatic tolerance, work capacity and eventually, brain death. The cause is often ascribed to inappropriate ... -
Differential Regulation of RNA Polymerase II Proximal-Pausing During Sexual Differentiation in Mice
During animal development, correct spatial and temporal gene expression is necessary to ensure the organism develops appropriately. Errors in gene regulation during development can result in any number of problems, resulting ... -
Digerud online GIS: developing an online community GIS resource in the Frogn municipal district of Norway
An increasing community demand for accurate, user friendly and easily accessible geographic information has lead to the development of online resources to aid in the decision making process (Craig et al, 2002, Green et al, ... -
Digital assessment of three-dimensional tooth movement during orthodontic activation using an optimised typodont system
CAD/CAM technology was used to develop an optimised typodont system, which allows three-dimensional simulation and quantification of orthodontic tooth movements. The system was then used to quantify movements associated ... -
A dirty determinant of health: What is the role of public health units in reducing the inequitable effects of inadequate income on health and wellbeing?
This study examines the role regional public health units could play in contributing to reducing the inequitable effects inadequate income has on health and wellbeing. It also recommends appropriate steps for Wellington’s ... -
Disarming tissue factor: generating a model tumour antigen
Coagulative abnormalities are a well-recognised feature of malignancy. The risk of developing thrombotic disorders is increased four-fold in cancer patients and more than six-fold higher in those receiving chemotherapy. ... -
DISC1 in Psychiatric Illness
Major psychiatric illnesses including bipolar disorder and schizophrenia can be highly debilitating and collectively have a lifetime incidence of approximately 1% in the general population. Twin and adoption studies have ... -
Discerning the mechanisms of Botrylloides diegensis during whole-body regeneration in single-cell resolution
Different organisms have varying regenerative capacities, some species are only able to regenerate several cell types, while others can regrow organs or multiple tissues. This is predicted to be a result of the inverse ... -
Disclosure or discourse? A critical examination of consent in research using surplus clinical tissue
Patient tissue samples are a valuable resource for medical research, and can therefore be used to contribute to the well-being of people in the future. It is common when using tissue for research to seek the consent of the ... -
Discourse, materiality and power: Dietary supplements and their users
Throughout human existence people have used herbs and other medicinal substances to protect themselves against illness and treat their ailments. Gathering wild herbs has, however, been replaced today by the many products ... -
Discovering the role of the Medicago truncatula SOC1 gene family in control of flowering time
Flowering in the legume Medicago truncatula (Medicago) is promoted in spring by long day (LD) photoperiod and vernalisation, exposure to winter cold, by the transcription factor MtFTa1. In Arabidopsis thaliana, flowering ... -
Discovery and Characterisation of Small Molecules that Block SARS-CoV-2 Replication In Vitro
In vitro drug screening has been a widely used approach to identify therapeutics for the treatment of many infectious diseases, including COVID-19. In late December 2019, a novel coronavirus (SARS-CoV-2, the etiological ... -
Discovery of Synthetic Lethal Interactions with CDH1 in Medulloblastoma
Medulloblastoma is the most frequently occurring malignant brain tumour in children, affecting just under two individuals per million annually. Medulloblastomas have an aggressive, invasive growth pattern, with a high risk ... -
Disease Gene Identification Using High-Throughput Genomic Technologies
Identification of the underlying genetic and molecular components that contribute to human disease can provide significant insight into the biological processes that underlie the development and regulation of affected ... -
Disposing of the Dead: An Investigation into Prehistoric Mortuary Practices During the Neolithic and Bronze Ages at Ban Non Wat, Thailand
Ban Non Wat is a prehistoric mounded site located in the upper Mun Valley of Northeast Thailand. It was excavated over five years under the Origins of the Civilization of Angkor research project, which uncovered 635 human ... -
Disrupting Bacterial Metal Ion Homeostasis to Break Antimicrobial Resistance
Antimicrobial resistance (AMR) describes a reduction in the efficacy of antimicrobial drugs (e.g., antibiotics) against pathogens (e.g., bacteria). This is a clinical issue of growing concern and directly caused over 1.28 ... -
Disrupting Pseudomonas aeruginosa quorum sensing
Many clinically relevant bacteria use a population-dependent communication network - known as quorum sensing - to regulate the processes essential for the establishment of infections. Quorum sensing enables pathogens to ... -
Dissecting alterations to arcuate nucleus neuropeptide Y neural circuitry in a model of polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is the most common form of infertility among women of reproductive age. Despite the prevalence of PCOS, the underlying mechanisms behind how PCOS arises and causes infertility remain poorly ...