Browsing Division of Health Sciences Departments by Title
Now showing items 1-20 of 2094
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11 week Beta-Hydroxy beta-Methylbutyric acid (HMB) supplementation: Effects on body composition and exercise performance in trained athletes.
Background: Originally used in the farming industry to ‘bulk up’ cattle, interest in the leucine metabolite, beta-hydroxy beta-methylbutyrate (HMB), has been growing following a clinical trial which demonstrated significant ... -
17α-hydroxylase and the androgen-treated sheep ovary – a model for Polycystic Ovary Syndrome (PCOS)
Polycystic Ovary Syndrome (PCOS) is the most common cause of infertility in women of reproductive age, with an estimated five to ten percent of women worldwide affected by the endocrine condition. The aetiology of PCOS ... -
2-pentylfuran: biosynthesis by Aspergillus fumigatus in-vitro and investigation of confounders of a breath test in-vivo
A. fumigatus is the principle cause of fatal invasive pulmonary aspergillosis (IPA) in severely immunocompromised hosts and rapid treatment is compromised by the limitations in the current diagnostic tests. 2-pentylfuran ... -
2.8 Å Structure of an ATP-bound Hsp70 from Escherichia coli
Heat shock protein 70 (Hsp70) is an important molecular chaperone of the proteostasis network, mediating protein folding and stability. Malfunction of proteostasis contributes to diseases as diverse as cancer and Alzheimer’s. ... -
24 – hour oxygen saturation recordings at discharge in preterm infants
Preterm infants have an immature respiratory system and therefore experience an increased number of respiratory pauses and oxygen desaturations. There is now advanced pulse oximetry technology that can record oxygen ... -
A Bioinformatics Approach to Synthetic Lethal Interactions in Cancer with Gene Expression Data
Introduction Synthetic lethal genetic interactions are re-emerging as an important concept in the post-genomics era due to their potential for use in precision medicine against cancers. Synthetic lethal drug design ... -
A case study of community action against alcohol harm: liquor licensing in Fantame Street, Porirua, 2011-2013
This thesis is a case study of local community involvement in the liquor licencing process. Alcohol is a widely available commodity with the potential for harm to communities through short and long term health impacts, ... -
A Case Study of Industrial Injury Reduction: New Zealand Aluminium Smelters Limited
Research aim: To assess the safety performance of New Zealand Aluminium SmeltersLimited (NZAS), 1971-2011. Research objectives sought 1) to quantify the NZAS safety improvement, and 2) to describe interventions used to ... -
A cohort study of psychosocial factors in relationship to pain in patients with Spinal Cord Injury and Stroke in New Zealand
Background. Pain is common after stroke and Spinal Cord Injury (SCI) and it affects the sufferer’s ability to engage in important activities. Little is known about the associations between psychosocial factors and pain ... -
A conceptual exploration of psychological distress following mild to moderate traumatic upper limb injuries
Psychological distress following severe traumatic hand injuries is common and has a significant influence on enduring disability and pain. In many studies, this distress is measured as symptoms of anxiety disorders such ... -
A cross comparison of technologies for the detection of microRNAs in FFPE samples from hepatoblastoma patients
MicroRNAs (miRNAs) are small non-coding RNA that regulate gene expression. Profiling miRNA patterns has provided insight into cancer. Formalin fixed paraffin embedded (FFPE) tissue is a major source of biological material, ... -
A Discourse Analysis of Self-management for Bipolar Disorder
In line with a movement across all areas of health concerned with chronic illness, self-management practices have become an important part of what it means to provide contemporary mental health care to people with the ... -
A FRET reporter of conformation in Hsc70
Hsp70s are the most well conserved protein family known, and yet little of their activity within the cell is understood. Hsc70 is a constitutively expressed member of the Hsp70 family found in the cytosol of almost all ... -
A functional Na-HCO3 cotransporter in the ileal villi of the common brushtail possum, Trichosurus vulpecula
In the intestine of eutherian mammals, such as human, rabbit, rat and mouse, fluid secretion is primarily driven by Cl- transport. However, in the ileum of possum (Trichosurus vulpecula), a metatherian mammal, the fluid ... -
A Genomic Investigation of Waddington’s Assimilation
Lamarck believed that traits acquired during an organism’s lifetime could be passed onto the next generation. Although this idea of the inheritance of acquired characters was discarded due to lack of experimental evidence, ... -
A Journey to the Good Life: A philosophical inquiry into the bioethical concept of human enhancement
If we wish to live a good life, then we ought to be good people. In order to be a good person one must respect and revere the will to live and promote life for ourselves and others in ways motivated by charity and ... -
A mechanical strain model for the assessment of periodontal ligament cell endoplasmic reticulum stress in three-dimensional culture
Introduction: The cellular basis of orthodontic tooth movement is complex, and is mediated by the biological responses of cells in the periodontal ligament (PDL) and alveolar bone. Appropriate homeostatic cytokine balance ... -
A Metabolic Health Study of Pacific Adolescents Investigating the metabolic health of Pacific adolescents in New Zealand: Environmental and genetic risk factors.
Adults of Pacific descent residing in New Zealand have more than double the prevalence of diabetes, obesity, gout and the metabolic syndrome (MS), compared to the general population. Genetic, biochemical and environmental ... -
A mixed methods study of musculoskeletal disorders in New Zealand nurses, postal workers and office workers
Musculoskeletal disorders (MSDs) among workers can lead to substantial personal, financial and societal costs. MSDs have a high prevalence among nurses, postal workers and office workers yet, at many anatomical sites, ... -
A new rat model for investigating the effects of alcohol on the adolescent brain: Acute and long-term effects
Adolescence represents a time of unique vulnerability to improper brain maturation, due to continued development of some frontal regions of the brain and a propensity for risky behaviours including alcohol use. Recently, ...