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Maternal obesity, placental and fetal brain development
Maternal obesity during pregnancy is associated with chronic low-grade inflammation and results in long-term health risks in the offspring. This thesis has investigated the hypothesis that elevated inflammatory responses ...
Neuroprotective effect of estradiol in mice with selective cholinergic lesions in nucleus basalis magnocellularis: morphological and behavioural studies
Basal forebrain cholinergic (BFC) neurons play a critical role in learning and memory and are highly affected in the age-associated neurodegenerative disorders such as Alzheimer’s disease (AD). Previous neurodegenerative ...
Modelling Red Blood Cell Data
The overarching aim of this work was to utilise modelling and simulation methodology to obtain a better understanding of clinical data generated from or in red blood cells (RBCs). It focussed on RBC survival and the use ...
The resected root-end: is what you see what you get? A naked-eye, optical and SEM study
Aims: To determine the influence of bur types and vision aids on the detection of cracks, root filling deficiencies and anomalies in resected root ends and on the quality of root-end cavities and fillings. To determine the ...
The Accuracy of Manual Fine Needle Aspiration Cytology in the Evaluation of Thyroid Cancer
Background
The most common endocrine malignancy is thyroid carcinoma. Thyroid carcinoma constitutes for 0.5% of all cancer deaths.
In New Zealand, thyroid carcinoma is less than 1% of all cancer registrations. In New ...
Leptin and insulin signaling on midbrain dopamine neurons do not modulate anxiety and depression behaviours
Anxiety is a highly aroused negative emotional state that occurs in response to potential danger, and can be inappropriately intensified due to aberrations in the aversion pathway of mesocorticolimbic dopamine circuitry. ...
Covariates in Pharmacometrics
Understanding the variability in drug response forms an important aspect of pharmacometrics. Various biological, statistical, clinical and mathematical concepts need to be considered to reach a unified decision point to ...
Myofibre death in elderly mouse skeletal muscles: The DEVILs lie within the details
The loss of lean muscle mass and strength in sarcopenia and dynapenia (respectively) has been largely attributed to myofibre atrophy, leaving the role of myofibre death unclear. The reported extent of myofibre loss between ...
Prolactin Signalling in the Median Eminence in the Mouse
The median eminence represents the interface between the hypothalamus and the portal blood, allowing access to the anterior pituitary and thus regulation of its secretion. The structure of the blood brain barrier at the ...
Assessment of Baroreflex Sensitivity and its Interaction with Cerebral Pressure-flow Dynamics
Abstract
Assessment of baroreflex sensitivity (BRS) is used extensively in research to study neural regulation of cardiovascular function, and BRS estimation offers a potential diagnostic and prognostic utility in ...