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Transcriptome analysis and annotation of Trichoderma virens, a beneficial plant fungal endophyte
Trichoderma is a ubiquitous, culturable genus of soil-borne fungi. Many species in the Trichoderma genus possess the ability to colonise plant roots and form mutualistic endophytic relationships. In particular, Trichoderma ...
Characterisation of Itch: The E3 Ubiquitin-Protein Ligase and Protein Protein Interaction Hub
Itch is an E3 ubiquitin-protein ligase that is an important negative regulator of inflammatory signalling, the viral immune response, and controls aspects of cellular differentiation and membrane-receptor sorting. Through ...
Excitatory ionotropic glutamate receptor expression in the reticular thalamic nucleus in a mouse model of absence epilepsy
Absence epilepsy refers to a group of genetic, generalized epilepsy syndromes associated with absence seizures, which are especially common in children and juveniles. Childhood absence epilepsy (CAE) is the most prevalent ...
Investigating non-pathogenic rabbit caliciviruses in New Zealand
Rabbit haemorrhagic disease virus (RHDV) is a pathogenic member of the Caliciviridae family. The Czech v351 isolate of RHDV is used in Australia and New Zealand as a biological control agent for rabbits, which are an ...
Functional Characterisation of Direct Neural Inputs to Arcuate Nucleus Kisspeptin Neurons in the Mouse
The pulsatile pattern of gonadotropin release is critical for puberty and fertility. Kisspeptin neurons in the arcuate nucleus (ARN) are thought to play an important role in generating pulsatile gonadotropin secretion. ...
Investigating the role of peroxiredoxin in hydrogen peroxide signalling
Hydrogen peroxide (H2O2) was viewed as an unwanted by-product of aerobic respiration for many years but it is now well-established as being involved in many different signalling pathways. H2O2 is reduced to water by ...
The Cytotoxic Mechanism of RL112 in Ovarian Cancer Cells
Background: Ovarian cancer is the most lethal gynecological malignancy among women, and there is limited treatment. The search for effective therapies for ovarian cancer has led to the emergence of natural compounds such ...
Interleukin-6 Signalling in the Murine Adrenal Gland
The adrenal gland is instrumental in the maintenance and restoration of homeostasis. This is mediated in part by catecholamine and glucocorticoid secretion from the adrenal medulla and cortex respectively. The catecholamine ...
T cell signalling in patients with colorectal cancer
T lymphocytes (T cells) are essential for mediating an effector response against tumours. High infiltrates of T cells in the tumour from colorectal cancer (CRC) patients are associated with positive patient outcomes, ...
Secreted amyloid precursor protein alpha regulates AMPA receptor synthesis and expression
Amyloid precursor protein, the parent molecule of the neurotoxic amyloid beta protein associated with Alzheimer’s disease, can also liberate the secreted amyloid precursor protein alpha (sAPPα). This molecule facilitates ...