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A novel central pathway for sympathetic activation in the early stages following an acute myocardial infarction
Acute myocardial infarction (MI) initiates an adverse and sustained increase in cardiac sympathetic nerve activity (SNA), which begins as early as 30 min after the infarct, provoking arrhythmias and is a leading factor for ...
Characterising a large population of langerin+, MHC-II+ cells in mouse skin wounds
Developing a thorough understanding of wound healing is crucial given the importance of the skin and the many challenges medical professionals face when it is damaged. The immune system is very involved in the healing ...
Investigating Disease Processes in CLN5 and CLN6 Batten Disease
The neuronal ceroid lipofuscinoses (NCL, Batten disease) are a heterogeneous group of inherited neurodegenerative disorders, clinically characterised by blindness, myoclonic epilepsy, cerebral atrophy, and progressive ...
Excitatory ionotropic glutamate receptor expression in the reticular thalamic nucleus in a mouse model of absence epilepsy
Absence epilepsy refers to a group of genetic, generalized epilepsy syndromes associated with absence seizures, which are especially common in children and juveniles. Childhood absence epilepsy (CAE) is the most prevalent ...
The reactions of superoxide with tyrosyl radicals on proteins
Superoxide is continuously removed from cells by superoxide dismutase (SOD). Genetic knockout studies have shown that SOD is crucial for survival, suggesting that higher levels of superoxide are damaging. Tyrosyl radicals ...
Exploring the anti-cancer and anti-inflammatory properties of isothiocyanates
Isothiocyanates are a class of phytochemicals responsible for the characteristic tastes and odours of cruciferous vegetables. Epidemiological evidence indicates that increased consumption of isothiocyanates is associated ...
Investigating a role for Fezf2 in the mature brain
The excitatory projection neurons (PNs) of the cortex encode the messages that are critical for mediating higher cognitive function. In the primary motor cortex (M1) PNs integrate signals, which regulate sensory driven and ...
Coping with the Impact of Multiple Sclerosis: A Grounded Theory Study
Introduction: Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system. MS generally progresses gradually, with alternating periods of remission, good health and disabling flare-ups. The ...
Achieving Equitable Asthma Services for Māori
Introduction:
Significant inequities exist in Aotearoa New Zealand for tamariki (children) Māori with asthma, who suffer a high burden of disease and high hospital admission rates, as compared to non-Māori. Primary ...
Walking towards health: Does size matter?
Physical activity is recommended for health, wellbeing, and to assist with weight management. Walking is the most popular leisure-time physical activity. National and international guidelines for the prescription of physical ...