Division of Health Sciences Departments: Recently added
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Sex, drugs, smokes and booze: What's driving teen trends? Describing and explaining trends in adolescent sexual behaviour, cannabis use, smoking and alcohol use in the early 21st century
Today’s adolescents are far less likely to smoke, drink, use drugs or be sexually active than their 1990s counterparts. My doctoral project set out to describe and explain trends in adolescent risk behaviours in the early ... -
Development of a viral chemokine binding protein as a diagnostic tool for chemokine detection.
Chemokines serve an integral role in the inflammatory response, specifically through the development of a chemotactic gradient which directs the trafficking of inflammatory leukocytes to the site of tissue damage or ... -
Non-Lamellar Liquid Crystalline Nanoparticles for Targeted Delivery of Endogenous Lipids to the Brain
Purpose: Bioactive endogenous lipids such as N-acylethanolamines (NAEs) and alkylglycerols have shown therapeutic potential in various neurological diseases and targeted brain drug delivery, respectively. However, their ... -
Dentists’ knowledge and experiences of treating patients with Head and Neck Cancer.
Background In Australasia, Head and Neck Cancer (HNC) is more common and survivable than ever before. As a result, the population prevalence of HNC patients (including HNC survivors) in our communities is ever-increasing. ... -
The effect of removing PsbJ in Synechocystis sp. PCC 6803 mutants that lack the extrinsic proteins of Photosystem II
Photosystem II (PS II) is the light-driven water-plastoquinone oxidoreductase of photosynthesis. PS II consists of 20 protein subunits including four core complexes forming the reaction centre, 13 additional low-molecular-weight ... -
Investigation of ubiquitin transfer by RING E3 ligases RNF121 and RNF114
Ubiquitylation is a post-translational modification that modulates protein turnover, function and localisation. The attachment of ubiquitin is achieved by a sophisticated enzyme cascade. Specificity is provided by E3 ... -
Transcriptional effects of mood stabiliser drugs in a serotonergic cell line
Sodium valproate (VPA) and lithium are drugs of different chemical classes that are widely prescribed in the treatment of bipolar disorder (BD). Molecular and pharmacological studies have revealed some relevant properties ... -
Is sarcopenia a neurodegenerative disease?
Sarcopenia is a major contributor to the loss of independence and deteriorating quality of life in elderly individuals. It is marked by declining skeletal muscle mass and strength beyond the age of 65. Sarcopenia places ... -
The regulation of ascorbate accumulation in plants
Ascorbate (Vitamin C) is vital to human health. We are unable to synthesise ascorbate and attain the majority of ascorbate from plants. Ascorbate accumulation is a complex, regulated and environmentally responsive trait ... -
Scaling of clearance by body size and composition
Dose scaling is a critical component of dose individualisation that helps ensure that the required amount of drug exposure is achieved in each and every patient. This is typically achieved by scaling the pharmacokinetic ... -
“TELL SOMEONE WHO CARES” – PARTICIPATORY ACTION RESEARCH OF MOTIVATION AND WORKPLACE ENGAGEMENT AMONG CAREGIVERS IN AGED RESIDENTIAL CARE, NEW ZEALAND
Ageing is an inevitable part of the human life cycle. Life for older adults can be active and independent, and often until late older age, but for some people older age means living in an aged residential care (ARC) facility. ... -
Characterisation of a new role for the UBA domain in ubiquitin chain synthesis by Ube2K
Ubiquitylation is a post-translational modification in which the protein Ubiquitin (Ub) is attached to other proteins, dictating their fate. Ubiquitylation requires the action of three groups of enzymes, Ub activating (E1) ... -
The Effect of Raw and Processed Bovine Milk Consumption on Immune Responses in Allergy and Health
A large body of epidemiological evidence shows that children who consume raw bovine milk in early life have reduced incidence of allergies and asthma in later life; while consumption of heat-treated, or processed milk, ... -
Effects of vasoactive agents on tumour blood flow and cytotoxic drug uptake.
Response of tumours to chemotherapy is limited by resistance, inherent or developing during treatment, causes of which include impaired drug delivery and changes in cellular drug transport. Although high-dose intravenous ... -
The Health Impacts of Increasing Social Inequality in Late Prehistoric Northeast Thailand
Evidence for increasing social inequality and a concurrent health deterioration has been observed in Iron Age (420BCE-500CE) northeast Thailand. Inequality is commonly considered to be represented by variations in quantities ... -
Cold and Crowded - The Early Childhood Education Environments Study
Background In recent decades New Zealand has seen a growth in the use of childcare as a weekday living environment for children under five years old, with an increasing proportion of children attending, and children ... -
Clinical and Surgical Anatomy of the Ligament of the Head of Femur
The ligament of the head of femur (LHF), or ligamentum teres, is an intra-articular ligament of the hip joint, running between the transverse acetabular ligament (TAL) of the hip and the fovea capitis femoris (FCF) on the ... -
Examining fatigue and performance in critical care clinicians
Background: Fatigue related to sleep deprivation has a degrading effect on human performance. In critical care health settings this represents a potential hazard to the safety of patients. This thesis aimed to identify and ... -
Toll like receptor signalling in human colonic organoids
Three-dimensional primary cultures of colonic epithelium, or colonic organoids, are thought to be a suitable culture system to investigate the properties of human intestinal epithelium and its interaction with commensal ... -
Assessment of central pain mechanisms: generating knowledge and resources for translation into clinical practice
Background: Musculoskeletal (MSK) disorders are the second most common cause of disability. Persistent MSK pain has been associated with altered central pain mechanisms (CPMs), particularly somatosensory abnormalities. In ...