Division of Health Sciences Departments: Recently added
Now showing items 1-20 of 2750
-
Microbial master-manipulators of mending
Recent work in our lab has uncovered an interesting connection between regeneration and the skin microbiome. Culturing tadpoles of the species Xenopus laevis in the antibiotic gentamicin has been shown to reduce the rate ... -
Kisspeptin regulation of oxytocin neuron activity in late pregnancy
Oxytocin triggers uterine contractions during parturition. My laboratory recently showed that the oxytocin neurons are excited by intracerebroventricular (ICV) administration of kisspeptin only in late-pregnant rats. ... -
Structural, functional, and proteomic investigations of muscle aging in the mouse
Declines in muscle mass and strength are hallmark features of sarcopenia, an age-related condition that contributes to morbidity and mortality in older people. Muscle mass is contingent on muscle fiber size and/or number; ... -
Circulating biomarkers and prognosis in colorectal cancer
Colorectal cancer is an important global health problem as the second most common cause of cancer deaths worldwide. The ability to risk-stratify patients according to predicted outcome is fundamental to patient management ... -
A proteomic insight into oxidative modifications of myofibrillar and sarcoplasmic proteins in venison after PEF treatment and ageing
For optimal and desired nutritional qualities, modern meat industries use various processing and ageing procedures. As a consequence of meat processing and ageing, it has been increasingly recognized that potential oxidation ... -
Non-alcoholic fatty liver disease (NAFLD): Nutrition triggers and weight loss treatment strategies
Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent condition, and is often referred to as the hepatic manifestation of the metabolic syndrome. It affects up to 30% of adults and up to 60-70% of those ... -
Is brain function impaired in moderate sleep apnoea: Before and after six months of APAP
The physiological impact of severe levels of obstructive sleep apnoea and the benefits of treatment are well documented. Yet more of the population suffer sleep apnoea of moderate severity. However, we still have substantial ... -
In vivo Characterisation of Plant Cysteine Dioxygenase
Plants not only produce oxygen, but also require molecular oxygen to live. Mitochondrial respiration in plants heavily relies on oxygen, and when there is a lack, the plant undergoes an energy crisis and other stresses, ... -
Dental health needs and access to dental care in low-income groups (including refugees and migrants)
Aims This study sought to identify the dental care needs of people on low incomes in Christchurch (including refugees and migrants). An attempt was also made to identify the barriers to access to dental care services ... -
Stereochemical basis for the anti-chlamydial activity of the phosphonate protease inhibitor JO146
JO146, a mixture of two diastereomers of a peptidic phosphonate inhibitor for Chlamydial HtrA (CtHtrA), has reported activity against Chlamydia species in both human and koala. In this study we isolated the individual ... -
Early innate immunity against mycobacterial infection
Infection by Mycobacterium tuberculosis is not consistently prevented by the only licensed vaccine, bacillus Calmette-Guérin (BCG). It is widely believed that adaptive immune memory confers protection against tuberculosis ... -
∆122p53 mice present persistent colitis following DSS treatment
Inflammatory bowel disease (IBD) is a leading health concern in New Zealand as it a lifelong condition that may cycle between periods of remission and relapse, often requiring extensive treatments and medical interventions. ... -
Essentiality of succinate metabolism in Mycobacterium tuberculosis
New drugs are urgently required to combat the tuberculosis epidemic that claims over 1.5 million lives annually. The identification of bedaquiline (BDQ) as an inhibitor of the mycobacterial F1Fo ATP synthase and its ... -
Oranga Mokopuna. Ethical co-designing for the pluriverse
In recent times, government appears to have conferred co-design a place of prominence in the future of hauora Māori. Yet an ever-increasing enthusiasm for co- design as ‘the solution’ has not equated with an increasing ... -
Therapeutic modulation of miRNA-320a to prevent diabetic cardiomyopathy
Recent findings reveal that more than 70% of diabetic individuals are prone to developing some form of heart disease during their life span. Population-based studies have shown that the risk of heart failure is augmented ... -
Development of Cryptococcus neoformans and Candida parapsilosis lanosterol 14α-demethylase (CYP51) as drug targets
Fungal infections afflict the well-being of a broad cross-section of the human population. These infections can be either superficial or invasive. While superficial infections may be readily treated, invasive fungal ... -
An investigation to optimise stimulation parameters of Remote Ischaemic Conditioning with digital stimulation
Background: Many ongoing clinical trials are investigating the ability of Remote Ischemic Conditioning (RIC) to limit ischemic injury in major organs such as the heart and brain, focussing on cardiac surgery, myocardial ...