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The transferability of modern medical laboratory technology to Fiji

Ranadi, Vilomena (Thesis, Master of Medical Science, 2017)

Medical technology has improved the health status of the population in developed countries. This has influenced the progress from intuitive medicine to precision medicine through the use of imaging, molecular biology and ...

The Chemokine-binding Proteins Encoded by Bovine Papular Stomatitis Virus and Parapoxvirus of Red Deer in New Zealand: Molecular and Functional Characterization

Sharif, Saeed (Thesis, Doctor of Philosophy, 2017)

Poxviruses are large DNA viruses that infect a wide range of animals including humans. During the course of evolution, these complex viruses have gained an extensive repertoire of immunomodulatory genes to evade host immune ...

N cycling and microbial dynamics in pasture soils

Samad, Md Sainur (Thesis, Doctor of Philosophy, 2017)

Pasture soils are a significant source of the greenhouse gas, nitrous oxide (N2O) and as such they contribute to global warming. It has been reported that N2O is approx. 300 times more potent than carbon dioxide (CO2) as ...

Maternity Outcomes and Access following Regulatory Changes for Isotretinoin Prescribing in New Zealand

McElroy, Jennifer (Thesis, Master of Health Sciences, 2017)

Aims: Oral isotretinoin is an effective treatment for severe acne that is teratogenic. On 1 March 2009 funded access to oral isotretinoin in New Zealand was extended from dermatologist-only to also include prescriptions ...

Understanding the risks of drinking water self-supplies from the perspective of rural people

Sullivan, Alexandra Jayne (Thesis, Master of Public Health, 2017)

Due to the potential for serious and widespread outbreaks of waterborne disease, managing the risk of microbiological contamination of drinking water is of particular importance. In New Zealand, drinking water quality and ...

Parental perceptions of the impact of early childhood caries in Malaysia and New Zealand

Nordin, Norhasnida (Thesis, Doctor of Philosophy, 2017)

Background The impact of Early Childhood Caries (ECC) and its treatment on the quality of life (QoL) of family members (especially the parents) has not been explored comprehensively. ECC is highly prevalent in NZ and ...

Identifying the best source of autologous progenitors for cardiac regeneration

Dixit, Parul (Thesis, Doctor of Philosophy, 2017)

Preliminary efficacy data indicates that stem cell transplantation has the potential to enhance myocardial perfusion and/or contractile performance in patients with ischemic heart disease. A significant challenge in ...

Caesarean Delivery on Maternal Request: A New Zealand Perspective

Dwight, Emily May (Thesis, Bachelor of Medical Science with Honours, 2017)

In many countries, including New Zealand, the caesarean delivery rate far exceeds the current WHO recommendation of 10-15% of live births. This is causing concern amongst a number of parties. One of the explanations for ...

The strategic behaviour of health workforce actors: Implications for health workforce planning and forecasting

Rees, Gareth Huw (Thesis, Doctor of Philosophy, 2017)

The effects of less than optimal health workforce numbers, skills or distributions are felt across the entire health system. Thus, the aim of health workforce planning is to meet the health system’s needs with a sustainable ...

Development of In-vitro Skin Models for Thermal Injury; to Investigate the Impact of Commensal Staphylococcus species on Wound Healing

Fleming, Jodie Sarah Min Lei (Thesis, Master of Science, 2017)

Skin is the largest organ of the body protecting our internal organs from physical injury, microbial invasion and infection. Healthy skin homeostasis relies on the interaction between the skin’s physical properties, its ...

Neutrophil killing of Staphylococcus aureus In Sepsis

Nazari, Shekufah (Thesis, Master of Science, 2017)

Neutrophils form the majority of circulating white blood cells and play a principle role in defending the body against invasions by microorganisms. Neutrophils engulf microorganisms into a phagosome where they kill them ...

Modulation of DNA methylation by L-ascorbate and 5-aza-2’-deoxycytidine in murine embryonic stem cells

Bridgman, Luke David (Thesis, Bachelor of Medical Science with Honours, 2017)

Cytosine methylation, normally found on cytosine residues adjacent to guanine (i.e., a CpG dinucleotide), is one means by which long-term gene repression occurs. Immediately after semi-conservative DNA replication, CpG ...

Cardiovascular risk in high altitude people of Nepal

Aryal, Nirmal (Thesis, Doctor of Philosophy, 2017)

Background Permanently living at high altitude (HA) directly affects the cardiovascular system because of lower arterial blood oxygen content compared to sea-level and other associated physiological changes. It is ...

The Teaching of Clinical Reasoning by Senior Clinicians

Anakin, Megan; Gee, Waverley; Pinnock, Ralph; Wilkinson, Tim; Henning, Marcus (Conference or Workshop Item (Poster), An International Association for Medical Education (AMEE), 2017)

Background. At our medical school, the teaching of clinical reasoning starts in a well-structured curriculum in the pre-clinical years. In the clinical years, however, teaching is less structured and delivered by multiple ...

Phenotypic and Molecular Analysis of the Alanine and Glutamate Racemases of Mycobacteria

Mortuza, Roman (Thesis, Doctor of Philosophy, 2017)

The enzymes alanine racemase (Alr) and glutamate racemase (MurI) catalyze the formation of the essential building blocks, D-alanine and D-glutamate, respectively, for cell wall biosynthesis. Despite their essential cellular ...

Exploring the work experiences of people with multiple sclerosis

Bladon, Rachel Anne (Thesis, Master of Health Sciences, 2017)

Background: The large variety of multiple sclerosis (MS) symptoms and its unpredictable disease course contributes to it having a negative impact in every area of life, with employment issues being of significant concern ...

The role of anti-Müllerian hormone in the brain’s response to steroid hormones

Sirisomboonwong, Korawan Erika (Thesis, Bachelor of Biomedical Sciences with Honours, 2017)

Many sexual dimorphisms that exist in the brain develop in the postnatal period. For males, this is when testosterone levels are minimal and anti-Müllerian hormone (AMH) is elevated. Testosterone requires the enzyme aromatase ...

The Antiviral Potential of Host Histone Deacetylase 11 during Influenza Virus Infection

Nutsford, Ashley (Thesis, Master of Science, 2017)

Influenza A virus (IAV) continues to have a major impact on global public health by causing regular seasonal epidemics, unpredictable pandemics and zoonotic outbreaks. These events also have significant implications for ...

The role of calcium calmodulin dependent protein kinase II in type 2 diabetic heart dysfunction

Daniels, Lorna Jane (Thesis, Doctor of Philosophy, 2017)

Type 2 diabetes is a well-established risk factor for cardiovascular disease, with the landmark Framingham study in the 1970’s reporting the incidence of heart failure is significantly higher in diabetic (DM) patients ...

Regulation of Zn2+ and aggregation affects Aβ1-42- induced changes in cell culture viability.

Potemkin, Nikita (Thesis, Master of Science, 2017)

In the story of the pathogenesis of Alzheimer’s Disease, Amyloid-Beta (Aβ) is believed to play a key role. However, evidence suggests that metal ions, in particular Zn2+, may have strong modulatory, or even causative effects ...

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