Division of Health Sciences Departments: Recently added
Now showing items 1-20 of 2220
-
Identification of synthetic lethal compounds targeting cancers with cohesin mutations
The cohesin complex, comprising four core subunits, RAD21, SMC3, SMC1A, and STAG1/2, is important for the regulation of many biological processes, including sister chromatid cohesion, regulation of gene expression, chromatin ... -
Factors affecting children’s oral care practices during the first 2 years of life
1. Background The main purpose of oral care practices for young children is to prevent dental caries. Oral care practices have 2 components: home care and professional dental care. Home oral care practice involves ... -
The forgotten arm of the fight-flight response: α-adrenergic control of the diabetic heart and interactions with Calmodulin Kinase 2
In Type 2 Diabetes Mellitus (T2DM) chronic metabolic stress and associated hemodynamic dysregulation result in a two-fold increase in cardiovascular disease (CVD) risk, making CVD a leading cause of death for T2DM patients ... -
Cell-penetrating peptides for enhanced oral delivery of nanoformulations
Introduction: Oral drug delivery systems such as polymeric nanoparticles are used to improve therapies that utilize biomacromolecules like proteins and peptides. Surface modifications of polymeric nanoparticles play a ... -
Child Poverty Monitor 2019: Technical Report
Children in Aotearoa New Zealand should be supported to live lives in which there are resources available for them to thrive, where they are experiencing wellbeing and opportunities to work towards fulfilling their potential, ... -
The mortuary practices of three prehistoric sites in northeast Thailand : an interpretation from the perspective of field anthropology
Burials from archaeological sites contain important information and differences between them suggest that the members of a community interred their dead in a specific and intentional manner. To form a comprehensive ... -
Regulation of cardiac ryanodine receptor 2 by protein kinase CK2
The cardiac muscle ryanodine receptor (RyR2) is an intracellular Ca2+ channel responsible for the release of Ca2+ during excitation-contraction coupling. It is also implicated in pathological store-overload-induced Ca2+ ... -
Characterising the relationship between Legionella longbeachae and their amoebal hosts: Implications for Legionnaires' disease prevention
In New Zealand, Legionella longbeachae is the leading cause of Legionnaires’ disease, a severe form of pneumonia that often results in hospitalisation and an intensive course of treatment. Every year, during spring and ... -
Exploring the perceptions of nursing students and nursing academic lecturers on the use of gallows humour in the clinical setting.
Past research on gallows humour in a healthcare context has generally focused on justifying its use by healthcare professionals during stressful situations as a temporary relief from the tragedy that is occurring. Some ... -
Targeted mutagenesis to investigate the role of low-molecular-weight proteins and a bicarbonate cofactor on the assembly and function of Photosystem II
Photosystem II (PS II) catalyses the oxidation of water at ambient temperatures and the formation of plastoquinol using light. This multisubunit complex functions as a dimer, each monomer is surrounded by 13 low-molecular-weight ... -
Atherogenic Index In Plasma and Risk of Cardiovascular Events
As dyslipidaemia is a prominent CVD risk factor, improvements in its management are crucial, as dyslipidaemia (quantified by hypercholesterolemia and treated with statins), incompletely addresses the residual CVD risk ... -
Arterial Hypertension. Consume Carbon Monoxide?
Epithelial sodium channels (ENaC) are generally responsible for the passive movement of sodium ions through the apical cell membrane of salt absorbing epithelia. Canonical ENaC is composed of three homologous subunits, ... -
Characterisation of Arcuate Nucleus Projections to the Paraventricular Nucleus of Thalamus
The metabolic state (fed or hungry) has been shown to influence varying responses to food-associated cues. Recent studies reveal that the paraventricular nucleus of the thalamus (PVT) may play a critical role as it receives ... -
A Novel Oocyte Cryopreservation Method using High Pressure Freezing
Oocyte cryopreservation (egg freezing) involves freezing a female’s oocytes in order to preserve her fertility. These oocytes can later be thawed and fertilised in vitro when she is ready to begin fertility treatment. Women ... -
Bacterial regulation of early activation of mucosal-associated invariant T (MAIT) cells
Mucosal-associated invariant T (MAIT) cells are a population of CD8+ innate-like T cells that play an important role in the immune response to bacterial infections. Being characterised by the expression of a unique ... -
The α-Adrenergic System and CaMKII in Diabetic Heart Disease
The relationship between diabetes mellitus and heart disease is widely documented, with heart disease being the main cause of mortality in diabetic patients. Diabetes impairs the autonomic nervous system, leading to an ... -
The Role of α-ENaC and δ-ENaC in Breast Cancer Cell Migration
Breast cancer is an important disease worldwide, primarily affecting women, and is the most common and deadliest form of female cancer. This is reflected in New Zealand’s population as breast cancer has high incidence and ... -
Candidate Compounds for the Chemoprevention of Hereditary Diffuse Gastric Cancer
Hereditary diffuse gastric cancer (HDGC) is a cancer syndrome caused by germline mutations in the tumour suppressor gene CDH1, which encodes the cell-cell adhesion protein E-cadherin. Mutations in CDH1 lead to increased ... -
Investigation into the Anticancer Mechanism of Action of Novel 4-Substituted Phenylthiazoles and Antihelminthic Benzimidazoles
Recently, two novel 4-substituted phenylthiazoles, D1 and D2, have been synthesised based upon the marine bacterial secondary metabolite anithiactin A/thiasporine C, and shown to be cytotoxic towards cancer cells below 100 ... -
Validation and Characterisation of Novel miRNAs Identified in the E15.5 Mouse Brain
MicroRNAs (miRNAs) are small noncoding elements that downregulate gene expression and play an important role in maintaining robust neurodevelopment. Since abnormal expression of miRNAs has been associated with disorders ...