Division of Health Sciences Departments: Recently added
Now showing items 1-20 of 1941
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Identifying the role of connexin 43 in transport of microRNAs
Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Present treatments for CVD rely heavily on surgical interventions and drug therapies that relieve symptoms rather than cure the disease. Therefore, ... -
The Impact of Epithelial Sodium Channel on Breast Cancer Cell Migration
Breast cancer is the most common cancer in New Zealand women, with the majority of breast cancer deaths being due to metastasis. This highlights the importance of identifying regulators and, thus, potential therapeutic ... -
Sodium and Uric Acid as Modulators of Vascular Endothelial ENaC
Hypertension, defined as a chronically high blood pressure, is a significant risk factor for heart attacks and strokes. Despite hypertension affecting 28% of individuals over the age of 20 years old, little is known about ... -
Modulation of Lineage Development in the Colonic Epithelium
Despite being exposed to microbial and food antigens, the human gastrointestinal tract does not exist in a state of inflammation. This homeostasis is critically dependent on the colonic epithelial barrier, which when ... -
Investigating the Effects of Chronic Low-Grade Inflammation on Cancer Immunotherapy
Cancer is the leading cause of death in New Zealand and is responsible for approximately one third of all deaths. Due to various factors, including unhealthy life style choices and an aging population, the number of new ... -
Balancing Safety and Developmental Potency: Assessing the Effect of Antioxidants and TET on Genomic Imprinting Stability.
Developmental potency represents the ability of undifferentiated cells to undergo transformation into differentiated cells, with specialised functions. The inner cell mass (ICM) of a blastocyst represents the most ... -
MR1 surface expression on primary blood cells and their role in mucosal associated invariant T (MAIT) cell activation
Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that bridge the innate and adaptive immune systems to provide rapid effector responses against a broad range of bacteria. MAIT cells are characterised ... -
Mapping post-stroke brain activation patterns: How do they change over time?
Stroke is a leading cause of death and long-term disability worldwide. Despite decades of research on neuroprotection, only few therapies are currently available to minimise the extent of infarction. As a result, researchers ... -
Can vitamin C reduce metastasis in a mouse model of breast cancer?
Ascorbate supplementation has been shown to reduce the aggressiveness of tumours in ascorbate-dependent Gulo-/- mice using both melanoma and lung cancer models. To date there is limited information on breast cancer growth ... -
Dissecting Estrogen Positive Feedback Mechanisms Using CRISPR-Cas9
Estrogen feedback mechanisms are arguably the most important component of mammalian fertility regulation. Estrogen positive feedback is mediated by a population of estrogen receptor alpha (ESR1)-expressing neuronal afferents ... -
Biomarkers and Lymph Node Morphology in Early-stage Colon Cancer
New Zealand has one of the highest rates of colorectal cancer (CRC) in the world, resulting in approximately 1200 deaths per year. Optimising the use of adjuvant chemotherapy is one key area to reduce CRC-related mortalities. ... -
Development of an in vivo model to investigate the effects of three adhesive removal methods around orthodontic brackets: A pilot study
Background Orthodontic treatment has increased significantly over the last two decades, however the prevalence of biofilm related complications in the form of white spot lesions (WSLs) is still unquestionably prevalent. ... -
"Fair, simple, speedy and efficient" : natural justice and the New Zealand health and disability commissioner - the first five years
This thesis is written by a midwife and lawyer who strongly supported the establishment of the Health and Disability Commissioner. With the enactment of the Health and Disability Commissioner Act 1994 ("HDCA") a new ... -
A longitudinal study of tooth formation and root resorption from birth to preadolescence
The findings of the present study provide information of considerable clinical value to the orthodontist and pedodontist. They also contain basic data for those interested in child growth and they contribute to the normative ... -
Oral Behaviours and Masseter Activity in Patients with Masticatory Muscle Pain
Background: Myogenous pain of the chewing muscles is a subgroup of temporomandibular disorder (TMD). It is a complex condition not fully understood at this time. One possible causal factor of myogenous TMD may be overloading ... -
Dental caries, tooth wear and dietary sugar intake in a sample of Northland Māori.
Background In New Zealand, there are well known disparities in oral health between different ethnicities and groups with different socioeconomic status. It has been recently shown that Māori are 1.8 times more likely to ... -
Hyperuricemia driven pancreatic β-cell dysfunction through Rictor, a subunit of mTORC2
The prevalence of diabetes mellitus, specifically type two diabetes mellitus (T2DM), is rapidly rising worldwide prompting research into mechanisms involved in T2DM progression and development. High plasma concentration ... -
Effect of incisal preparation design on stress distribution and load-to-failure of ceramic veneers
Background: The incisal preparation designs for ceramic veneers have been widely discussed in the dental literature. Incisal preparation can be divided into two broad categories: overlap and non-overlap. The overlap group ... -
The Restorative Management of Dental Caries affecting Children and Adolescents in New Zealand
Background With an increase in knowledge and understanding and alongside the development of materials, there has been a fundamental change in the management of dental caries. Contemporary management is governed by minimal ... -
“It depends on the consultation”: Revisiting use of family members as interpreters for general practice consultations – when and why?
Family members continue to be used as interpreters in medical consultations despite the well-known risks. This paper examines participant perceptions of this practice in three New Zealand clinics chosen for their frequent ...