Division of Health Sciences Departments: Recently added
Now showing items 1-20 of 2275
-
Ion homeostasis in Mycobacterium smegmatis
Microorganisms must maintain equilibrium and intracellular availability of ions for growth and persistence in a range of environments, either in the face of scarce resources or excesses, whereby they must buffer, exclude ... -
Application of second and third generation sequencing in pharmacogenetics
The next generation sequencing technologies have advanced pharmacogenetics by enabling rapid assessment of the entire exome or even whole genome for associations between variants or gene regions with drug response. Third ... -
Evaluation of a pilot breast cancer screening programme
A pilot mammographic breast cancer screening programme was established in 1991 for women aged fifty to sixty-four living in Otago and Southland. The pilot programme was evaluated to measure the acceptability, effectiveness, ... -
Manipulation of the host cell cycle by murine norovirus VPg
Human norovirus (HuNV) is a leading cause of acute gastroenteritis worldwide. Despite advances in HuNV cell culture the virus remains difficult to study in the laboratory. Murine norovirus (MNV) is routinely utilised as a ... -
Public health organization in four rural districts in Western Samoa.
In the light of the modern world, the inhabitants of underdeveloped countries, of which Samoa in the strict sense of the word is one, of them, frequently in their lower level of knowledgeable resources, referred to foreign ... -
Cholinergic modulation of cortical sensory-evoked responses
Cholinergic inputs to the cortex from the basal forebrain are essential for performing complex behaviours that require precise integration of sensory and motor information. However, the role of the basal forebrain cholinergic ... -
Understanding altered intrinsic heart rate in type 2 diabetes
Heart rate (HR) is generated by sinoatrial node (SAN) intrinsic pacemaking and modulated by autonomic innervation. Within the SAN, intrinsic (ex vivo) HR is determined by the mutual entrainment of the sarcolemmal voltage ... -
Constitutive PD-L1 expression in melanoma
Treatment of melanoma based on targeted therapy and immunotherapy has dramatically advanced over the past decade. Advances in targeted therapy have been based on inhibition of the MAPK pathway while for immunotherapy, ... -
Persistent musculoskeletal pain in individuals with inflammatory bowel diseases
Background: Pain affects over 70% of individuals with inflammatory bowel disease (IBD), with abdominal and musculoskeletal (MSK) pain representing the most common complaints identified by patients. To date most studies in ... -
Investigating the Influence of Metabolic Syndrome on Cancer Immunotherapy
Cancer is a significant cause of morbidity in New Zealand, with breast and colorectal cancers being amongst the most commonly diagnosed. Therapeutic research has moved into immunotherapies, harnessing the immune system to ... -
Regulation of cardiac ryanodine receptor 2 by protein kinase CK2
The cardiac muscle ryanodine receptor (RyR2) is an intracellular Ca2+ channel responsible for the release of Ca2+ during excitation-contraction coupling. It is also implicated in pathological store-overload-induced Ca2+ ... -
Modeling RECQL4 developmental syndromes in Xenopus laevis using CRISPR/Cas9
There are a number of human genetic conditions of abnormal skeletal development associated with disrupted DNA replication, with several linked to mutations in RECQL4. While several mouse models targeting Recql4 have been ... -
Multiplex ddPCR for the detection of tumour-specific mutations in ctDNA
Circulating tumour DNA (ctDNA) are short extracellular DNA fragments that have been explored by a number of studies to potentially reflect a more complete representation of tumour burden without utilizing the highly invasive ... -
Dose adjustment based on renal function
Patients with impaired kidney function are at risk of excessive drug exposure and toxicity when standard doses of renally cleared drugs are used. Dose adjustment to normalise drug exposure between patients may be required ... -
MUSIC for Medical Students: Confirming the Reliability and Validity of A Multi-Factorial Measure of Academic Motivation for Medical Education
Construct: The MUSIC® Inventory measures the construct of academic motivation across five factors: empowerment, usefulness, success, interest, and caring. The factors are defined in terms of the degree the student perceives ... -
Rotavirus Specific Maternal Antibodies and Immune Response to RV3-BB Neonatal Rotavirus Vaccine in New Zealand
Background: Rotavirus specific maternal antibodies acquired passively via placental and/or breast milk may contribute to the reduced oral rotavirus vaccine efficacy observed in children in developing countries. This study ... -
Staying at home: A qualitative descriptive study on Pacific palliative health
Background: The New Zealand population is rapidly ageing and the need for palliative care in New Zealand is increasing (Ministry of Health, 2017b). Pacific people in New Zealand are known to have low rates of palliative ... -
Exploring senior secondary health education in Aotearoa New Zealand: A cabinet of curiosities
Senior secondary Health Education in Aotearoa New Zealand is somewhat of a curiosity: Often misunderstood and certainly under-researched. The school subject is uniquely placed internationally; one which can contribute to ... -
Communication and collaboration between general practitioners and acupuncturists in New Zealand: A case study of integrated mental health care
General practitioners (GPs) play an important role in integrated care management of primary mental health, and in most cases act as the primary provider and access point for further services. In recent years more service ... -
Predicting the Response to Radiotherapy for Rectal Cancer
Aim To investigate predictors of pathological response to radiotherapy for rectal cancer by reviewing the evidence, exploring clinicopathological predictors in a local cohort and investigating markers of oxidative stress ...