Division of Health Sciences Departments: Recently added
Now showing items 1-20 of 2025
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The Twilight Zone of Nucleotide Homology
Homology search tools are important for inferring homology in the abundance of genomes currently sequenced. These tools utilise sequence similarity in order to assign a score between two sequences from which homology is ... -
EEG Biofeedback for Memory
The brain has an ordered structure of functional connections within brain networks, but this order becomes disrupted in Alzheimer’s disease (AD). The default mode network (DMN) and its central hub, the Posterior Cingulate ... -
Exosome mRNA localisation: Directing mRNA localisation to exosomes
Exosomes are small vesicles containing proteins, miRNAs and mRNAs. Exosomes are secreted and taken up by neighbouring cells and the contents move into the recipient cell, where they are biologically active (e.g. the mRNA ... -
Convergent and divergent validity of the Participation and Environment Measure for Children and Youth (PEM-CY)
Introduction: Robust measures of children’s participation and environments are critical to understanding the impact of health and social conditions on children and young people. One widely used measure, the Participation ... -
Postural stability in older adults with mild to moderate cognitive impairment and Alzheimer’s disease
Older adults with Alzheimer’s disease are at high risk of experiencing falls; their risk is double that of their healthy peers. The guidelines for achieving a fall risk reduction via an exercise-based intervention, for ... -
Inhibitory Receptor Expression by T Cells in Colorectal Tumours
Inhibitory receptor (iR) expression is a hallmark of T cell dysfunction. In situations of chronic antigen exposure, such as in a tumour, antigen-specific T cells undergo a shift in programming, which makes them more ... -
Trans Wretchedness Theory and disrupting the focus on negative health outcomes
The number of academic publications on transgender, non-binary, and gender diverse (TGD) health issues has been steadily increasing over the years. This would generally be an indicator that health science is gaining a ... -
Investigations into the roles of two flavoproteins in mycobacterial physiology
Members of the genus Mycobacterium contain species that are adapted to thrive under a wide variety of environmental conditions. A key factor in the life cycle of mycobacteria is their ability to persist in the absence of ... -
Understanding the genetic basis for competitive nodule formation by clover rhizobia
Clovers enter a symbiotic relationship with particular rhizobia through a highly specific and complex signal exchange culminating in the formation of nitrogen-fixing root nodules. Legumes exude flavonoids that are perceived ... -
Running through the fog: A feasibility study on early exercise implementation in sports-related concussion recovery
Safely advising a sports related concussion (SRC) patient though their recovery presents risks to the clinician, coach, and most importantly, to the athlete affected. The current consensus holds that there is insufficient ... -
The foundation and content of a moral right to health care
This thesis addresses the question "Is there a moral right to health care, and, if so, what does it entail?" In nearly all Western countries except the United States, the idea of a right to health care is taken for granted. ... -
The morphology of the lumbar paraspinal, gluteal and piriformis muscles in chronic sacroiliac joint pain
The sacroiliac joint (SIJ) can be identified as the source of pain in approximately 10-45% of patients suffering from chronic low back pain. It is hypothesised that SIJ pain may be associated with an imbalance of force ... -
Predicting the impact of chemoprophylaxis strategies against leprosy in South Tarawa, Kiribati
Background Leprosy is widely thought to be a disease of the past, but globally there are still around 200,000 new cases annually. Current strategies of early diagnosis and treatment are proving ineffective in interrupting ... -
Endosomal SNX Proteins are Required for Recycling of the Epithelial Sodium Channel.
The epithelial sodium channel (ENaC) facilitates Na+ absorption of polarised epithelia and is required for regulation of salt and water homeostasis. ENaC’s apical membrane population is strictly controlled, and loss of ... -
Preparation and evaluation of oral nanoformulations containing antioxidant rutin
Purpose Oxidants induce oxidative stress in the body playing an important role in the development of diseases such as cancer, arthritis, cardiovascular and neurological disease. Rutin - a strong antioxidant - can scavenge ... -
The pathophysiological role of microRNAs in diabtic cardiac stem cells
Cardiac stem cells (CSCs) have been implicated as the most suitable source of stem cells in regenerating the diseased heart. However, diabetes is known to cause a progressive loss in the functional efficacy of CSCs. MicroRNAs ... -
The pathophysiology of the cerebello-thalamic pathway in Parkinson's disease.
Parkinson’s disease (PD) presents with characteristic movement deficits that are thought to evolve as a consequence of degeneration of dopamine neurons in the brain. The degree of PD motor symptoms strongly correlates to ... -
Biochemistry and Biophysics of the ASK1-Prdx1 Axis
Peroxiredoxin 1 (Prdx1) is an abundant cytoplasmic human thiol peroxidase. It functions to detoxify reactive oxygen species, in particular, hydrogen peroxide (H2O2). The canonical mechanism of Prdx1 activity involves the ... -
Cohesin and Regulation of Gene Expression During Zebrafish Development
Made up of four subunits, Structural Maintenance of Chromosomes (SMC) proteins, the SMC1 and SMC3 subunits, Rad21 and stromalin antigens (SA1/2), the ring- shaped protein cohesin is an essential part of both the mitotic ...