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dc.contributor.advisorKelly, Lyndell
dc.contributor.advisorMolteno, Anthony CB
dc.contributor.authorOliver, Genevieve
dc.date.available2016-02-23T00:43:32Z
dc.date.copyright2016
dc.identifier.citationOliver, G. (2016). Stereotactic radiotherapy of uveal melanoma: The Dunedin Experience (Thesis, Master of Ophthalmology). University of Otago. Retrieved from http://hdl.handle.net/10523/6234en
dc.identifier.urihttp://hdl.handle.net/10523/6234
dc.description.abstractUveal melanoma is a rare disease causing significant mortality. Metastatic disease - for which there is no treatment - often occurs before the primary tumor is diagnosed. In addition to enucleation, there are many globe-sparing ways of treating the primary tumour. Fractionated stereotactic radiotherapy is one such treatment, delivering a homogenous dose of radiation to the tumour and allowing normal tissue the chance to recover between fractions. The aim of this thesis was to evaluate the effectiveness of fractionated stereotactic radiotherapy for the treatment of uveal melanoma in the New Zealand population. The main outcome measurements were local tumour control, visual acuity, radiogenic side effects and metastatic death. A retrospective audit of clinical notes was performed on all patients with uveal melanoma treated with fractionated stereotactic radiotherapy in Dunedin, New Zealand, from July 2001 to December 2007. All twenty-seven patients treated during this period were included. Local control was achieved in all patients. Three patients required secondary enucleation for intractable pain, recurrent vitreous cavity haemorrhage, and recurrent retinal detachment. Visual acuity deteriorated in eighteen of the remaining twenty-four patients (75%), and mean Snellen acuity dropped from 6/6 at baseline to 6/21 at final follow-up. Eight patients developed radiation retinopathy, one patient developed optic neuropathy, and two patients developed neovascular glaucoma. At final follow-up, three patients were known to have died of metastatic disease. Fractionated stereotactic radiotherapy is an eye-sparing treatment option for patients with uveal melanoma. Data from this study supports international literature that this is a useful addition to the treatment armamentarium for this cancer.
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherUniversity of Otago
dc.rightsAll items in OUR Archive are provided for private study and research purposes and are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectNew Zealand
dc.subjectuveal melanoma
dc.subjectchoroidal melanoma
dc.subjectstereotactic radiotherapy
dc.titleStereotactic radiotherapy of uveal melanoma: The Dunedin Experience
dc.typeThesis
dc.date.updated2016-02-22T23:01:52Z
dc.language.rfc3066en
thesis.degree.disciplineDepartment of Ophthalmology
thesis.degree.nameMaster of Ophthalmology
thesis.degree.grantorUniversity of Otago
thesis.degree.levelMasters
otago.openaccessOpen
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