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dc.contributor.advisorBaird, Sarah
dc.contributor.authorClarke, Mitchell Raymond
dc.date.available2016-02-29T23:04:51Z
dc.date.copyright2016
dc.identifier.citationClarke, M. R. (2016). A Novel Mechanism for Nicotinic Acetylcholine Receptor Antagonist-Induced Cancer Cell Cytotoxicity (Thesis, Master of Science). University of Otago. Retrieved from http://hdl.handle.net/10523/6244en
dc.identifier.urihttp://hdl.handle.net/10523/6244
dc.description.abstractNicotinic acetylcholine receptors (nAChRs) are common ligand-activated neurotransmitter receptors located throughout the body. The up-regulation of nAChRs subunits has been observed in a number of cancer types; while current literature has identified various nAChR pathways that contribute to the development of cancer. The present study identified a novel mechanism for the observed cytotoxicity of the highly potent nAChR antagonist, pinnatoxin (PnTX), on human epithelial carcinoma cell lines. Cell cycle and intracellular calcium studies suggest that PnTX exerts its cytotoxic effects by inducing changes in the cell cycle via antagonism of the highly calcium permeable α7-, and to a certain extent, the α4β2-nAChR receptors. This leads to an induction of cell apoptosis via calcium-independent pathways. The use of nAChRs in combination with other known cytotoxic agents, such as cyclosporin A, or apoptotic inducing chemotherapy agents, may provide a sensitising tool that can reduce the dose required to elicit a cytotoxic response on developing tumours.
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherUniversity of Otago
dc.rightsAll items in OUR Archive are provided for private study and research purposes and are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectNicotinic
dc.subjectAcetylcholine
dc.subjectPinnatoxin
dc.subjectnAChR
dc.subjectCytotoxicity
dc.subjectCalcium
dc.subjectCancer
dc.subjectAntagonist
dc.titleA Novel Mechanism for Nicotinic Acetylcholine Receptor Antagonist-Induced Cancer Cell Cytotoxicity
dc.typeThesis
dc.date.updated2016-02-29T22:06:46Z
dc.language.rfc3066en
thesis.degree.disciplinePharmacology and Toxicology
thesis.degree.nameMaster of Science
thesis.degree.grantorUniversity of Otago
thesis.degree.levelMasters
otago.openaccessOpen
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