|dc.description.abstract||The context for this study is public concern about aerial spraying of biological insecticides over Auckland, New Zealand between January 2002 and May 2004. We analysed childhood asthma hospital admissions for the whole of New Zealand, July 1999 – December 2004 using a spatial scan statistic. We found spatial clustering of asthma admissions in many New Zealand cities, and spatiotemporal clustering in a few cities. We hypothesize that many of the purely spatial clusters might be explained by characteristics of the local population or health services.
This explanation is less plausible in the case of the observed space-time clusters of asthma admissions, which we consider more likely to be related to local exposures. In spatiotemporal models, there were significant clusters in Auckland, Palmerston North, Lower Hutt, Christchurch and Invercargill. Two of the four Auckland clusters overlap biological insecticide spray zones, and two do not; the majority of the observed spatiotemporal clusters are unrelated to aerial spraying of biological insecticides in space and time. While the present results do not allow us to identify which local exposures are most relevant in explaining the observed spatiotemporal clusters, we hypothesize that air pollution, including fine particles of biological and non-biological origin, might play a role.||en_NZ
|dc.description.references||Anselin, L. (1999). Interactive techniques and exploratory spatial data analysis. Geographical Information
Systems: principles, techniques, management and applications. P. A. Longley, M. F. Goodchild, D. J. Maguire
and D. W. Rhind. New York, John Wiley: pp 253-266.
Aylin, P., Maheswaran, R., Wakefield, J., Cockings, S., Jarup, L., Arnold, R., Wheeler, G. & Elliott, P. (1999).
A national facility for small area disease mapping and rapid initial assessment of apparent disease clusters
around a point source: the UK Small Area Health Statistics Unit. Journal of Public Health Medicine 21: 289-
Becker, S., Dailey, L., Soukup, J., Silbajoris, R. & Devlin, R. (2005) TLR-2 is involved in airway epithelial cell
response to air pollution particles. Toxicology and Applied Pharmacology 203: 45– 52.
Burney P. (1999) Air pollution and asthma; the dog that doesn’t always bark. Lancet 353:859-860.
Douwes J., Thorne, P., Pearce, N. & Heederik, D. (2003) Bioaerosol Health Effects and Exposure Assessment:
Progress and Prospects. Ann Occup Hyg 47: 187–200.
Hales S. (2004) Precautionary health risk assessment: a case study of biological insecticides. EcoHealth 1: 399–
Kulldorff, M., Athas, W., Feurer, E., Miller, B. & Key, C. (1998) Evaluating cluster alarms: A space-time scan
statistic and brain cancer in Los Alamos. American Journal of Public Health, 88:1377-1380.
Kulldorff, M. and Information Management Services Inc (2002). SaTScan v3.0: Software for the spatial and
space-time scan statistics. Bethesda, MD, USA, National Cancer Institute.
Openshaw, S., Charlton, M., Wymer, C. & Craft, A. (1987). A mark I geographical analysis machine for the
automated analysis of point data sets. International Journal of Geographical Information Systems 1:335-358.
Rothman, K. (1990). A sobering start for the cluster buster's conference. American Journal of Epidemiology
132(suppl 1): S6-13.
Sabel, CE. & M. Löytönen (2004). Clustering of disease. GIS in Public Health Practice. R. Maheswaran and M.
Craglia. London: CRC Press: 51-67.
Sabel, CE., Boyle, P., Löytönen, M., Gatrell, A., Jokelainen, M., Flowerdew, R & Maasilta, P. (2003). The
spatial clustering of Amyotrophic Lateral Sclerosis in Finland at place of birth and place of death. American
Journal of Epidemiology 157: 898-905.
Teschke K., Chow, Y., Bartlett, K., Ross, A., & van Netten, C. (2001) Spatial and Temporal Distribution of
Airborne Bacillus thuringiensis var. kurstaki during an Aerial Spray Program for Gypsy Moth Eradication.
Environmental Health Perspectives 109:47-54.
Wartenberg, D. (2001). Investigating disease clusters: why, when and how? Journal of the Royal Statistical
Society Series A - Statistics in Society 164: 13-22.
WHO (1999) Environmental Health Criteria 217. Geneva: World Health Organisation.
WHO (2005) Effects of air pollution on children’s health and development. Bonn: World Health Organisation.||en_NZ