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dc.contributor.advisorDuncan, Warwick
dc.contributor.advisorSchmidlin, Patrick
dc.contributor.advisorLeichter, Jonathan
dc.contributor.authorSheftel, Yevgeny
dc.date.available2017-11-13T22:01:19Z
dc.date.copyright2017
dc.identifier.citationSheftel, Y. (2017). Novel grafting materials for sinus floor elevation in the sheep model (Thesis, Doctor of Clinical Dentistry). University of Otago. Retrieved from http://hdl.handle.net/10523/7738en
dc.identifier.urihttp://hdl.handle.net/10523/7738
dc.description.abstractIntroduction: Sinus floor elevation (SFE) may be required for implant placement in the severely resorbed posterior maxilla. Although often successful, autologous bone grafting requires a donor site and may lose substantial volume while remodelling. Bone replacement grafting (BRG) materials were developed to overcome these limitations. This study investigated three novel grafting materials: 1) equine collagen cone (CN), 2) equine collagen cone filled with biphasic calcium phosphate particles (CO), 3) deproteinized bovine bone particles coated with polylactic acid and poly ε -caprolactone copolymer (SB). These were compared with the most commonly-used bovine bone BRG, Geistlich Bio-Oss® (BO). Methods: The extra-oral access sinus grafting model from Haas et al. (1998) was used in 11 cross-bred female sheep. Two experimental sites on each side of the animal were prepared. CN, CO, SB, BO were each placed through separate 10 mm access window in the antral wall, under the elevated Schneiderian membrane. BO sites were covered with a porcine collagen membrane (Geistlich Bio-Gide®), while for CO, SB, BO sites the equine collagen membrane (RESORBA PARASORB®) from the manufacturer of these experimental materials was used. The animals were euthanised after 16 weeks. New bone, residual graft particles and connective tissue areas were measured on un-demineralised resin-embedded sections. Results: One sheep did not survive the surgery. All sites in remaining ten sheep healed uneventfully. The CN and SB grafting materials resorbed completely and failed to form new bone. BO and CO particles were bridged by the new bone, the new bone fraction was 10% (±9%) for BO and 4% (±5%) for CO. The differences were not statistically significant. Conclusions: CN and SB cannot be recommended for sinus grafting, based on this model. BO and CO demonstrated comparable histologic and histomorphometric outcomes.
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherUniversity of Otago
dc.rightsAll items in OUR Archive are provided for private study and research purposes and are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectsheep
dc.subjectsinus
dc.subjectaugmentation
dc.subjectfloor
dc.subjectgrafting
dc.subjectgraft
dc.subjectCone-Oss
dc.subjectCone
dc.subjectOss
dc.subjectBioOss
dc.subjectbeta
dc.subjectTCP
dc.subjectsmartbone
dc.subjectSmarbone
dc.subjecthydroxyapatite
dc.titleNovel grafting materials for sinus floor elevation in the sheep model
dc.typeThesis
dc.date.updated2017-11-13T11:36:27Z
dc.language.rfc3066en
thesis.degree.disciplineOral Sciences
thesis.degree.nameDoctor of Clinical Dentistry
thesis.degree.grantorUniversity of Otago
thesis.degree.levelDoctoral
otago.openaccessOpen
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