Synthesis and Utilization of Novel Chromone Based Scaffolds
|dc.contributor.author||Clark, Mitchell Robert|
|dc.identifier.citation||Clark, M. R. (2018). Synthesis and Utilization of Novel Chromone Based Scaffolds (Thesis, Master of Science). University of Otago. Retrieved from http://hdl.handle.net/10523/7933||en|
|dc.description.abstract||The chromone moiety (11) is a common structural motif found in a wealth of natural products and medicinally relevant compounds. Its synthesis has been investigated for over 100 years, yet opportunities still remain for the development of synthetic methods which provide a broader substrate scope and increased efficiency. The synthesis of 3 from 4 was discovered by members of our group, which provided a novel way of accessing the chromone scaffold. This new method showed promising signs of overcoming problems encountered in established synthetic methodology and provided chromones in moderate to good yields (30 – 60%). Additionally, this method provides functional handles, not accessible by established methodology, which we envisioned could be used to provide access to further elaborated natural product-like scaffolds. This project investigated the scope of this reaction by varying portions of the molecule. The synthetic utility of the reaction was then explored by attempting a number of modifications to the relevant chromones, most notably the divinyl cyclopropane rearrangements to access chromone fused cycloheptadienes (76).|
|dc.publisher||University of Otago|
|dc.rights||All items in OUR Archive are provided for private study and research purposes and are protected by copyright with all rights reserved unless otherwise indicated.|
|dc.title||Synthesis and Utilization of Novel Chromone Based Scaffolds|
|thesis.degree.name||Master of Science|
|thesis.degree.grantor||University of Otago|
Files in this item
There are no files associated with this item.
This item is not available in full-text via OUR Archive.
If you would like to read this item, please apply for an inter-library loan from the University of Otago via your local library.
If you are the author of this item, please contact us if you wish to discuss making the full text publicly available.