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dc.contributor.authorDameh, Mustafaen_NZ
dc.contributor.authorWhigham, Peter Aen_NZ
dc.contributor.authorStanton, Jo-Annen_NZ
dc.contributor.authorGreen, Daviden_NZ
dc.date.available2011-04-07T03:03:08Z
dc.date.copyright2004-11en_NZ
dc.identifier.citationDameh, M., Whigham, P. A., Stanton, J.A., & Green, D. (2004, November). Spatial location of genes within cells in gene interaction networks. Presented at the 16th Annual Colloquium of the Spatial Information Research Centre (SIRC 2004: A Spatio-temporal Workshop).en
dc.identifier.urihttp://hdl.handle.net/10523/801
dc.descriptionOnly the abstract was published in the proceedings. There is no full text.en_NZ
dc.description.abstractText mining techniques have become a popular method for discovering relationships between genes based on searching the biomedical literature. The co-occurrence of gene names within individual documents is used to produce hypothetical interaction networks, which are used to explore hypotheses regarding gene interaction. However, the incorporation of the spatial interaction between gene products, although highly informative to the biologists, has largely been ignored. Although the use of interaction networks has some promise, there are additional sources of information within literature that is not normally exploited. In particular, gene interaction is a significantly spatial activity, with genes being expressed in different ways depending on where they are located within a cell. Biomedical literature uses a set of keywords that describe an abstract set of locations or compartments within a cell, and these are often used in conjunction with the description of gene activity. The incorporation of spatial relationships between network elements within the cell is likely to increase the interpretation and value of these hypothetical networks. For example, the cells physical space can be shown when producing a visualization of the gene network. The topological relationship between abstract cell sites can be used to verify and isolate gene interactions according to their spatial location within the cell. This talk will present a methodology for incorporating spatial location of genes into gene interaction networks and the challenges that are likely to be faced when applying this approach.en_NZ
dc.format.mimetypeapplication/pdf
dc.relation.urihttp://www.business.otago.ac.nz/SIRC05/conferences/2004/14_Dameh.pdfen_NZ
dc.subjectphysical spaceen_NZ
dc.subjectgene networksen_NZ
dc.subjectvisualisationen_NZ
dc.subjectgene locationen_NZ
dc.subject.lcshQR Microbiologyen_NZ
dc.subject.lcshQR180 Immunologyen_NZ
dc.subject.lcshQR355 Virologyen_NZ
dc.subject.lcshQM Human anatomyen_NZ
dc.titleSpatial location of genes within cells in gene interaction networksen_NZ
dc.typeConference or Workshop Item (Oral presentation)en_NZ
dc.description.versionPublisheden_NZ
otago.date.accession2005-11-30en_NZ
otago.relation.pages57en_NZ
otago.openaccessOpen
dc.identifier.eprints102en_NZ
dc.description.refereedNon Peer Revieweden_NZ
otago.school.eprintsSpatial Information Research Centreen_NZ
otago.school.eprintsInformation Scienceen_NZ
otago.school.eprintsAnatomy & Structural Biologyen_NZ
otago.event.dates29-30 November 2004en_NZ
otago.event.placeDunedin, New Zealanden_NZ
otago.event.typeconferenceen_NZ
otago.event.title16th Annual Colloquium of the Spatial Information Research Centre (SIRC 2004: A Spatio-temporal Workshop)en_NZ
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