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dc.contributor.advisorFrizelle, Francis Anthony
dc.contributor.advisorEglinton, Timothy
dc.contributor.authorSharma, Prashant Vinay
dc.date.available2018-06-20T01:45:44Z
dc.date.copyright2018
dc.identifier.citationSharma, P. V. (2018). Influence of Risk Factors on Incidence, Management, Recurrence, and Follow-up of Acute Diverticulitis. (Thesis, Master of Medical Science). University of Otago. Retrieved from http://hdl.handle.net/10523/8115en
dc.identifier.urihttp://hdl.handle.net/10523/8115
dc.description.abstractAcute Diverticulitis is a significant problem, accounting for up to one third of acute surgical admissions. Despite significant and rapid advances in medical knowledge, it remains a poorly understood disease. Practice is influenced by historical studies which have significant flaws. Current practice may be a reflection of limitations of the past e.g. the lack of accurate Cross Sectional Imaging. Technology is advancing and historical practices such as routine colonoscopy after diverticulitis may not be required. Risk factors for acute diverticulitis and recurrent diverticulitis remain unclear. With western society changing, diseases such as obesity are increasing. These may have influence on acute diverticulitis, its course and recurrence. Similarly other poorly understood risk factors include use of Non-Steroidal and Steroid medications, and the influence of Diabetes and autoimmune diseases. This thesis is an attempt to clarify these questions. Chapter 1 addresses the historical research and evidence that formed the basis of current practice. In Chapter 2 we address the effect of BMI and other risk factors on acute diverticulitis, and found that obese patients may be at increased risk. In chapter 3 we addressed the role of colonoscopy and found that the risk of malignancy after a confirmed episode of uncomplicated diverticulitis is not significantly different to that of a screened asymptomatic population, while complicated diverticulitis still carries a significant risk. In chapter 4, we looked at recurrent diverticulitis, and found that uncomplicated disease at initial presentation, having an autoimmune disease and taking regular NSAIDS increased risk of recurrent disease.
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherUniversity of Otago
dc.rightsAll items in OUR Archive are provided for private study and research purposes and are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectDiverticulitis
dc.subjectColonoscopy
dc.subjectRecurrence
dc.subjectObesity
dc.subjectMalignancy
dc.titleInfluence of Risk Factors on Incidence, Management, Recurrence, and Follow-up of Acute Diverticulitis.
dc.typeThesis
dc.date.updated2018-06-20T01:24:53Z
dc.language.rfc3066en
thesis.degree.disciplineDepartment of Surgery, Christchurch Public Hospital
thesis.degree.nameMaster of Medical Science
thesis.degree.grantorUniversity of Otago
thesis.degree.levelMasters
otago.openaccessOpen
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