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dc.contributorChapple, Cathy M.
dc.contributorStebbings, Simon
dc.contributorSangelaji, Bahram
dc.contributorBaxter, G. David
dc.contributor.authorBuhler, Miranda
dc.date.available2018-10-22T19:53:35Z
dc.date.copyright2018
dc.identifier.citationBuhler M, Chapple CM, Stebbings S, Sangelaji B, David Baxter G, Effectiveness of splinting for pain and function in people with thumb carpometacarpal osteoarthritis: a systematic review with meta-analysis, Osteoarthritis and Cartilage (2018), doi: https://doi.org/10.1016/j.joca.2018.09.012en_NZ
dc.identifier.urihttp://hdl.handle.net/10523/8465
dc.descriptionThis is a PDF file of an unedited post-print version of a manuscript that has been accepted for publication. The final version of the accepted manuscript is now available online at: https://doi.org/10.1016/j.joca.2018.09.012 Please note access to the full text of the final manuscript version will depend on your personal or institutional entitlements. This early version of the manuscript is made available to you here to provide fast access to the article and is not intended to be the final version of the article. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.en_NZ
dc.description.abstractObjective: To examine the effectiveness of splinting for reducing pain and improving function and health-related quality of life (HR-QoL) in people with thumb base osteoarthritis (OA). Design: The Cochrane Library, MEDLINE, Embase, CINAHL, ISI Web of Science, Scopus and Google Scholar, 3 trial registries and 2 conference proceedings were systematically searched for randomised and non-randomised controlled trials up to March 17th, 2018. Two reviewers independently applied the inclusion criteria to select potential studies and assess risk of methodologic bias using the Cochrane Collaboration’s Risk of Bias Tool. Studies were pooled using the inverse variance method to calculate standardised mean difference (SMD). Sensitivity analyses were conducted and the quality of evidence for each outcome was judged following the GRADE approach. Results: Twelve studies were retrieved (n=1353), 4 comparing a splint to control and 8 to another splint. In the medium-term (3-12 months), low quality evidence showed that splints cause a moderate to large reduction in pain (SMD 0.7 [95% CI 1.04, 0.35], P < 0.0001) and small to moderate improvement in function (SMD 0.42 [95% CI 0.77, 0.08], P = 0.02). No significant effect was found at short-term or for different types of splints. No studies reported HR-QoL. Conclusions: Splinting demonstrated a moderate to large effect for pain and small to moderate effect for function in the medium-term but not in the short term. Quality of the evidence is low. Major challenges are the lack of diagnostic criteria for thumb base OA and of a gold-standard outcome measure.en_NZ
dc.format.mimetypeapplication/pdf
dc.language.isoenen_NZ
dc.publisherElsevieren_NZ
dc.relation.ispartofOsteoarthritis and Cartilageen_NZ
dc.subjectThumb; Trapeziometacarpal; Osteoarthritis; Splints; Systematic Review; Meta-Analysisen_NZ
dc.titleEffectiveness of splinting for pain and function in people with thumb carpometacarpal osteoarthritis: a systematic review with meta-analysisen_NZ
dc.title.alternativeEffectiveness of splinting for pain and function in people with thumb base osteoarthritis: a systematic review with meta-analysisen_NZ
dc.typeJournal Articleen_NZ
dc.date.updated2018-10-19T02:34:58Z
otago.schoolCentre for Health, Activity and Rehabilitation Research, School of Physiotherapyen_NZ
dc.identifier.doihttps://doi.org/10.1016/j.joca.2018.09.012en_NZ
otago.openaccessOpenen_NZ
dc.rights.statementASSIGNMENT OF COPYRIGHT I hereby assign to Osteoarthritis Research Society International the copyright in the manuscript identified above (where Crown Copyright is asserted, authors agree to grant an exclusive publishing and distribution license) and any tables, illustrations or other material submitted for publication as part of the manuscript (the "Article"). This assignment of rights means that I have granted to Osteoarthritis Research Society International, the exclusive right to publish and reproduce the Article, or any part of the Article, in print, electronic and all other media (whether now known or later developed), in any form, in all languages, throughout the world, for the full term of copyright, and the right to license others to do the same, effective when the Article is accepted for publication. This includes the right to enforce the rights granted hereunder against third parties. .... AUTHOR RIGHTS FOR SCHOLARLY PURPOSES I understand that I retain or am hereby granted (without the need to obtain further permission) the Author Rights (see description below), and that no rights in patents, trademarks or other intellectual property rights are transferred to Osteoarthritis Research Society International. The Author Rights include the right to use the Preprint, Accepted Manuscript and the Published Journal Article for Personal Use and Internal Institutional Use. They also include the right to use these different versions of the Article for Scholarly Sharing purposes, which include sharing: the Preprint on any website or repository at any time; the Accepted Manuscript on certain websites and usually after an embargo period; the Published Journal Article only privately on certain websites, unless otherwise agreed by Osteoarthritis Research Society Internatio In the case of the Accepted Manuscript and the Published Journal Article the Author Rights exclude Commercial Use (unless expressly agreed in writing by Osteoarthritis Research Society International), other than use by the author in a subsequent compilation of the author's works or to extend the Article to book length form or re-use by the author of portions or excerpts in other works (with full acknowledgment of the original publication of the Article).en_NZ
dc.description.refereedPeer Revieweden_NZ
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