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dc.contributor.advisorKatare, Andrew Bahn
dc.contributor.authorPurvis, Nima
dc.date.available2019-04-02T22:59:24Z
dc.date.copyright2019
dc.identifier.citationPurvis, N. (2019). The pathophysiological role of microRNAs in diabtic cardiac stem cells (Thesis, Doctor of Philosophy). University of Otago. Retrieved from http://hdl.handle.net/10523/9211en
dc.identifier.urihttp://hdl.handle.net/10523/9211
dc.description.abstractCardiac stem cells (CSCs) have been implicated as the most suitable source of stem cells in regenerating the diseased heart. However, diabetes is known to cause a progressive loss in the functional efficacy of CSCs. MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate genes at the post-transcriptional level. This study investigated whether dysregulation of miRNAs could be the underlying cause for the functional deterioration of diabetic CSCs and whether genetic manipulation of miRNAs can improve their function. Diabetes caused significant dysregulation of miR-329, -495, -376c and -30c in both mouse and human diabetic CSCs. Moreover, elevated expression of miR-30c was suggested to improve the survival of the diabetic CSCs.
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherUniversity of Otago
dc.rightsAll items in OUR Archive are provided for private study and research purposes and are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectmicroRNA
dc.subjectdiabetes
dc.subjectstem cell
dc.subjectcardiovascular disease
dc.titleThe pathophysiological role of microRNAs in diabtic cardiac stem cells
dc.typeThesis
dc.date.updated2019-04-02T22:29:16Z
dc.language.rfc3066en
thesis.degree.disciplinePhysiology
thesis.degree.nameDoctor of Philosophy
thesis.degree.grantorUniversity of Otago
thesis.degree.levelDoctoral
otago.openaccessOpen
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