Synthesis of oligosaccharides for functionalization of RHDV VLP
Virus-like particles (VLP) present a promising platform for antigen delivery in anticancer vaccines. Conjugation of rabbit hemorrhagic disease virus (RHDV) VLP and simple mannoside components have been shown to increase the immune response generated by targeting cross presentation via receptor mediated endocytosis. It has been postulated that conjugation to cellular receptors’ ideal ligands will lead to a further increase in immune response. A series of oligosaccharides based on the mannose receptor’s ideal biological ligands with linkers terminating in an activated ester have been synthesized for conjugation to RHDV VLP and further immunological investigations.
Advisor: Larsen, David S.
Degree Name: Doctor of Philosophy
Degree Discipline: Chemistry
Publisher: University of Otago
Keywords: New Zealand; Carbohydrates; Synthesis; Organic chemistry
Research Type: Thesis