Show simple item record

dc.contributor.advisorLarsen, David S.
dc.contributor.authorHall, Elise
dc.date.available2019-10-13T22:18:48Z
dc.date.copyright2019
dc.identifier.citationHall, E. (2019). Synthesis of oligosaccharides for functionalization of RHDV VLP (Thesis, Doctor of Philosophy). University of Otago. Retrieved from http://hdl.handle.net/10523/9669en
dc.identifier.urihttp://hdl.handle.net/10523/9669
dc.description.abstractVirus-like particles (VLP) present a promising platform for antigen delivery in anticancer vaccines. Conjugation of rabbit hemorrhagic disease virus (RHDV) VLP and simple mannoside components have been shown to increase the immune response generated by targeting cross presentation via receptor mediated endocytosis. It has been postulated that conjugation to cellular receptors’ ideal ligands will lead to a further increase in immune response. A series of oligosaccharides based on the mannose receptor’s ideal biological ligands with linkers terminating in an activated ester have been synthesized for conjugation to RHDV VLP and further immunological investigations.
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherUniversity of Otago
dc.rightsAll items in OUR Archive are provided for private study and research purposes and are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectNew Zealand
dc.subjectCarbohydrates
dc.subjectSynthesis
dc.subjectOrganic chemistry
dc.titleSynthesis of oligosaccharides for functionalization of RHDV VLP
dc.typeThesis
dc.date.updated2019-10-13T20:52:23Z
dc.language.rfc3066en
thesis.degree.disciplineChemistry
thesis.degree.nameDoctor of Philosophy
thesis.degree.grantorUniversity of Otago
thesis.degree.levelDoctoral
otago.openaccessOpen
 Find in your library

Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record